ἐστίν: the gen. with εἶναι expresses here the object with which the art has to do.
τοῦ: introduces all the following gens., and also the advs. πορρωτέρω and ἐγγυτέρω. Cf. 356 a, l. 33, where the advs. μᾶλλον καὶ ἧττον are co-ordinated with μείζω τε καὶ σμικρότερα κτἑ. With φαίνεται is to be supplied ἡ σωτηρία τοῦ βίου οὖσα.