Scientists discover brain waste-disposal system that may help prevent Alzheimer's

 Oh my, almost 10 years later we do the same research over again. can't you blithering idiots keep up-to-date and create the research that activates this disposal system on demand rather than this waste of time and money? Your mentors and senior researchers are that incompetent?

 

TransportDEMENTIA – treating dementia by activating the waste disposal system of the brain  December 2015

 And this:

Dementia Tied to Large Perivascular Spaces January 2021

The latest here:

Scientists discover brain waste-disposal system that may help prevent Alzheimer's

The brain has a waste-disposal system that clears away junk proteins that contribute to the development of dementia and Alzheimer's disease, a new study finds.

Advanced imaging scans have revealed a network of fluid-filled structures along arteries and veins within the brain, researchers reported Monday in the Proceedings of the National Academy of Sciences.

These structures allow cerebrospinal fluid to flow through the brain, potentially flushing out waste proteins like amyloid and tau, researchers said.

Those toxic proteins build up in the brains of Alzheimer's patients, creating plaques and tangles that are hallmarks of the disorder.

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Previous research found these sort of fluid channels in the brains of mice, but this is the first time they've been confirmed to exist in humans as well, researchers said.

"Nobody has shown it before now," said senior researcher Dr. Juan Piantino, an associate professor of pediatric neurology in the Oregon Health & Science University (OHSU) School of Medicine.

"This shows that cerebrospinal fluid doesn't just get into the brain randomly, as if you put a sponge in a bucket of water," Piantino added in a university news release. "It goes through these channels."

For the study, researchers injected five patients undergoing brain surgery at OHSU with a tracer that would be carried with cerebrospinal fluid into the brain.

The research team then used MRI scans to track the spread of the tracer throughout the brain.

Images showed that the fluid moved along clearly defined channels in the brain, which researchers called "perivascular spaces."

"You can actually see dark perivascular spaces in the brain turn bright," said co-lead researcher Dr. Erin Yamamoto, a resident in neurological surgery in the OHSU School of Medicine.

Researchers believe the pathways help flush out waste that's been generated by the brain, similar to the way that the lymphatic system flushes waste generated by the immune system throughout the body.

"People thought these perivascular spaces were important, but it had never been proven," Piantino said. "Now it has."

Future research can focus on ways to improve this waste-disposal system in the brain, researchers noted.

For example, quality sleep is believed to help the system better flush waste proteins out of the brain, they said.

More information

The Alzheimer's Association has more on amyloid beta.

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Dementia Tied to Large Perivascular Spaces

Useless, described a problem, OFFERED NO SOLUTION.

Dementia Tied to Large Perivascular Spaces

Enlarged spaces around cerebral small blood vessels linked to cognitive decline over time

by Judy George, Senior Staff Writer, MedPage Today January 27, 2021

Enlarged fluid-filled spaces around cerebral small blood vessels were linked to cognitive decline, a prospective study of older adults showed.

Severe perivascular space pathology in both the basal ganglia and the centrum semiovale, or in the centrum semiovale alone, was tied to a greater drop in global cognition over 4 years, reported Matthew Paradise, MBChB, MSc, of the University of New South Wales in Sydney, Australia, and co-authors.

Large perivascular space dilation in both brain regions was an independent predictor of dementia across 8 years of follow-up (adjusted OR 2.91, 95% CI 1.43-5.95, P=0.003), with stronger effects at either year 4 or 6, the researchers wrote in Neurology.

Dilated perivascular spaces are a common MRI finding especially in older patients, but their clinical relevance is unclear, Paradise noted. "Our study suggests that dilated perivascular spaces should no longer be considered just an incidental finding but have an important role in evaluating cognitive decline," he told MedPage Today.

"Cerebrovascular disease is increasingly recognized not only as an inmportant cause of cognitive impairment and dementia directly, but also as an important contributor to the risk and progression of Alzheimer's disease," Paradise added. "Despite this, we're not very good at assessing the overall burden from cerebrovascular disease which can make diagnosis of, say, vascular dementia, difficult."

As people get older, and in some diseases, perivascular spaces around cerebral small vessels can enlarge, noted David Werring, PhD, of UCL Queen Square Institute of Neurology in London, England, who wasn't involved with the study. "This raises the possibility that perivascular spaces could be a marker of disease process affecting these small vessels," he said.