Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Showing posts with label EPA. Show all posts
Showing posts with label EPA. Show all posts

Monday, September 9, 2024

Eating Small Fish Might Offer Big Benefits for Longevity, Study Shows try #2

 

Is this going to change your hospital's diet protocol from salmon several times a week?  Or is your hospital so FUCKING INCOMPETENT they have never written up a diet protocol for all these conditions?

For dementia prevention; for cognitive improvement; for cholesterol reduction; for plaque removal; for Parkinsons prevention; for inflammation reduction; etc.

Do you prefer your  doctor and hospital  incompetence NOT KNOWING? OR NOT DOING?

 

Eating Small Fish Might Offer Big Benefits for Longevity, Study Shows

I removed the link since it was pointing to a low trust website, so you'll have to google the title


Is a Fiber Supplement Just as Good as Fiber From Food?

In recent years, the spotlight on nutrition has turned towards small fish as a powerhouse for promoting health and longevity. A growing body of research indicates that incorporating small fish into our diets can provide substantial health benefits, potentially extending life expectancy. This article delves into the nutritional profile of small fish, the health benefits they offer, and the environmental advantages of consuming them.

Nutritional Profile of Small Fish

Small fish, such as sardines, anchovies, mackerel, and herring, are packed with essential nutrients that are crucial for maintaining good health. They are excellent sources of high-quality protein, which is vital for muscle repair and overall body function. Additionally, small fish are rich in omega-3 fatty acids, which are essential fats that the body cannot produce on its own.

Omega-3 fatty acids, particularly eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), play a critical role in brain function, reducing inflammation, and lowering the risk of chronic diseases such as heart disease. Small fish also provide a good dose of vitamins and minerals, including vitamin D, vitamin B12, calcium, and selenium. These nutrients are vital for bone health, immune function, and protecting the body against oxidative stress.

Health Benefits of Consuming Small Fish

Cardiovascular Health

One of the most well-documented benefits of consuming small fish is their positive impact on cardiovascular health. Studies have shown that the omega-3 fatty acids found in small fish can help reduce triglycerides, lower blood pressure, decrease the risk of arrhythmias, and slow the development of plaque in the arteries. Regular consumption of small fish is associated with a lower risk of heart attacks and strokes, making them an excellent choice for heart health.

Brain Health and Cognitive Function

The omega-3 fatty acids in small fish are also crucial for brain health. DHA, in particular, is a major structural component of the brain and retina. Adequate intake of DHA is essential for the proper development and function of the brain, especially in infants and children. In adults, omega-3s can help maintain cognitive function and may reduce the risk of cognitive decline and Alzheimer’s disease. Some studies suggest that regular consumption of small fish can improve memory and overall brain performance.

Anti-Inflammatory Properties

Chronic inflammation is a common underlying factor in many diseases, including arthritis, cancer, and heart disease. Omega-3 fatty acids have potent anti-inflammatory properties that can help reduce inflammation in the body. By incorporating small fish into your diet, you can benefit from these anti-inflammatory effects, potentially reducing the risk of chronic diseases and promoting overall health.

Small Fish and Environmental Sustainability

Lower Environmental Impact

Eating small fish is not only beneficial for health but also for the environment. Small fish generally occupy lower positions in the food chain, which means they are more abundant and reproduce faster than larger fish. This makes them a more sustainable option compared to overfished species like tuna and salmon. Additionally, small fish typically require fewer resources and produce lower levels of pollutants, making them an eco-friendly choice.

Reducing Overfishing of Larger Species

By choosing small fish, consumers can help reduce the demand for larger, often overfished species. This can contribute to the recovery of marine ecosystems and help maintain biodiversity. Sustainable fishing practices and mindful consumption are essential for preserving the health of our oceans and ensuring a steady supply of seafood for future generations.

Practical Tips for Incorporating Small Fish into Your Diet

Easy and Versatile Recipes

Incorporating small fish into your diet can be simple and delicious. Small fish can be enjoyed in a variety of ways, from grilling and baking to adding them to salads, pasta, and sandwiches. Sardines on toast, anchovies in Caesar salad, and mackerel pâté are just a few examples of how versatile and tasty small fish can be.

Choosing Quality Products

When selecting small fish, it’s important to choose high-quality, sustainably sourced options. Look for products with certifications from reputable organizations like the Marine Stewardship Council (MSC) to ensure that you are supporting sustainable fishing practices. Fresh, frozen, and canned small fish can all be good options, depending on availability and convenience.

Conclusion

Incorporating small fish into your diet can offer significant health benefits, from improved cardiovascular health and cognitive function to reduced inflammation. Their rich nutritional profile, particularly their omega-3 fatty acid content, makes them an excellent addition to a balanced diet. Furthermore, choosing small fish can help promote environmental sustainability by reducing the pressure on overfished species and supporting healthier marine ecosystems.

As more research continues to highlight the benefits of small fish, it’s becoming clear that these tiny powerhouses can play a big role in promoting longevity and overall well-being. So, next time you’re planning your meals, consider adding some small fish to your plate and enjoy the myriad benefits they have to offer.

Monday, September 11, 2023

Two omega-3s in fish oil may boost brain function in people with heart disease

 WHOM is going to do the research in stroke patients?  I can guarantee nothing will be done because we have NO LEADERSHIP AND NO STRATEGY in stroke.

Two omega-3s in fish oil may boost brain function in people with heart disease

Two omega-3 fatty acids found in fish oil may help improve brain function in older adults who have a type of heart disease known to put people at risk for cognitive decline.

A new study found that DHA and EPA, given in a combined supplement at prescription levels, improved cognitive function in older adults with coronary artery disease, or CAD. It is a common type of heart disease that occurs when plaque builds up in the arteries and hinders proper blood flow. Studies have shown people with CAD have a 45% increased risk for cognitive decline.

The largest improvements in brain function were seen when higher levels of both types of omega-3 fatty acids were present in the bloodstream. When analyzed individually, DHA levels were a better predictor for cognitive improvement than EPA, suggesting the presence of one type of omega-3 fatty acid was more important than the other, the authors concluded.

"The study showed EPA adds additional benefit when DHA levels are already high," said study researcher Dr. Francine Welty, an associate professor of medicine at Harvard Medical School in Boston. "But EPA levels alone had no predictive ability for cognitive improvement."

The findings, a further analysis of data published in March in the American Journal of Clinical Nutrition, are being presented next Monday at the American Heart Association's virtual Scientific Sessions by Welty's colleague and lead researcher Dr. Abdulaziz Malik, a cardiology fellow at Tufts Medical Center in Boston. The findings are considered preliminary until published in a peer-reviewed journal.

The study included 291 adults with stable CAD. They averaged 63 years old, and 83% were men. None showed problems with cognition at the beginning of the study.

Half were given 3.36 grams of EPA and DHA combined, and half were not. All participants received cognitive function tests at baseline, one year after treatment began and at the end of 30 months. The tests measured verbal fluency, language and memory; visual motor coordination; and processing speed. Blood tests at the end of the study measured DHA and EPA levels.

The team hoped to show long-term, high-dose omega-3 fatty acids could prevent cognitive decline in people with CAD but were surprised to find the supplements did much more than that, Welty said.

"They actually showed an improvement in cognitive function," she said. Those were the results published in March.

In the new analysis, the team looked at changes in the levels of EPA and DHA in the blood of participants who took the supplements, to see if higher levels of each of the fatty acids predicted the cognitive improvements. While higher DHA aligned with better performance on cognitive tests, higher EPA levels did not seem to make a difference – except in people who had high levels of DHA to begin with, Welty said.

"Someone who wants to use fish oil supplements to improve cognitive function should get a prescription for a supplement that combines the two," Welty said. She cautioned against buying over-the-counter supplements, which are not regulated by the Food and Drug Administration.

The same level of omega-3 fatty acids used in the study could not be obtained just through diet, said Penny Kris-Etherton, an Evan Pugh University professor of nutritional sciences at Penn State College of Health and Human Development in University Park.

"Getting 3.36 grams per day is hard to do just eating fish," said Kris-Etherton, who was not involved in the new study.

"You'd have to eat a lot of fatty fish every single day. One serving of fatty fish, which is 3.5 ounces of salmon, for example, has about 2.2 to 2.3 grams of omega-3 fatty acids. To get 3.36 grams per day means that you'd have to eat about 1 1/2 servings of fatty fish every day. The recommendation of two fish meals per week, including fatty fish and lean seafood like shrimp, would only get you about 0.25 gram per day, and most Americans don't even eat that much."

Omega-3 fatty acids are highest in fatty fish such as salmon, sardines, mackerel, herring, lake trout and albacore tuna. The AHA recommends eating two servings of fish per week to help reduce heart disease and stroke risk. It issued a science advisory in 2019 saying prescription fish oil supplements were a safe and effective way to lower triglycerides. The same advisory warned consumers not to take unregulated supplements.

A separate AHA science advisory issued in 2017 said omega-3 fish oil supplements may slightly lower the risk of dying after heart failure or a recent heart attack, but they do not prevent heart disease. Kris-Etherton co-authored both advisories.

"What I'm excited about is we're finding interventions that benefit cognitive function as we age," she said.

Kris-Etherton would like to see a similar study in older adults without heart disease to see if the supplements would provide a similar or greater benefit to others as they age. "Stay tuned," she said. "These are very interesting findings."

Find more news from Scientific Sessions.

If you have questions or comments about this story, please email editor@heart.org.

Wednesday, April 27, 2022

Two omega-3s in fish oil may boost brain function in people with heart disease

What about for stroke patients? You can't do this on your own, note that these fish oils are prescription strength. Do ask your doctor  how to get these benefits.

Two omega-3s in fish oil may boost brain function in people with heart disease

By Laura Williamson, American Heart Association News

Obencem/iStock, Getty Images
(Obencem/iStock, Getty Images)

Two omega-3 fatty acids found in fish oil may help improve brain function in older adults who have a type of heart disease known to put people at risk for cognitive decline.

A new study found that DHA and EPA, given in a combined supplement at prescription levels, improved cognitive function in older adults with coronary artery disease, or CAD. It is a common type of heart disease that occurs when plaque builds up in the arteries and hinders proper blood flow. Studies have shown people with CAD have a 45% increased risk for cognitive decline.

The largest improvements in brain function were seen when higher levels of both types of omega-3 fatty acids were present in the bloodstream. When analyzed individually, DHA levels were a better predictor for cognitive improvement than EPA, suggesting the presence of one type of omega-3 fatty acid was more important than the other, the authors concluded.

"The study showed EPA adds additional benefit when DHA levels are already high," said study researcher Dr. Francine Welty, an associate professor of medicine at Harvard Medical School in Boston. "But EPA levels alone had no predictive ability for cognitive improvement."

The findings, a further analysis of data published in March in the American Journal of Clinical Nutrition, are being presented next Monday at the American Heart Association's virtual Scientific Sessions by Welty's colleague and lead researcher Dr. Abdulaziz Malik, a cardiology fellow at Tufts Medical Center in Boston. The findings are considered preliminary until published in a peer-reviewed journal.

The study included 291 adults with stable CAD. They averaged 63 years old, and 83% were men. None showed problems with cognition at the beginning of the study.

Half were given 3.36 grams of EPA and DHA combined, and half were not. All participants received cognitive function tests at baseline, one year after treatment began and at the end of 30 months. The tests measured verbal fluency, language and memory; visual motor coordination; and processing speed. Blood tests at the end of the study measured DHA and EPA levels.

The team hoped to show long-term, high-dose omega-3 fatty acids could prevent cognitive decline in people with CAD but were surprised to find the supplements did much more than that, Welty said.

"They actually showed an improvement in cognitive function," she said. Those were the results published in March.

In the new analysis, the team looked at changes in the levels of EPA and DHA in the blood of participants who took the supplements, to see if higher levels of each of the fatty acids predicted the cognitive improvements. While higher DHA aligned with better performance on cognitive tests, higher EPA levels did not seem to make a difference – except in people who had high levels of DHA to begin with, Welty said.

"Someone who wants to use fish oil supplements to improve cognitive function should get a prescription for a supplement that combines the two," Welty said. She cautioned against buying over-the-counter supplements, which are not regulated by the Food and Drug Administration.

The same level of omega-3 fatty acids used in the study could not be obtained just through diet, said Penny Kris-Etherton, an Evan Pugh University professor of nutritional sciences at Penn State College of Health and Human Development in University Park.

"Getting 3.36 grams per day is hard to do just eating fish," said Kris-Etherton, who was not involved in the new study.

"You'd have to eat a lot of fatty fish every single day. One serving of fatty fish, which is 3.5 ounces of salmon, for example, has about 2.2 to 2.3 grams of omega-3 fatty acids. To get 3.36 grams per day means that you'd have to eat about 1 1/2 servings of fatty fish every day. The recommendation of two fish meals per week, including fatty fish and lean seafood like shrimp, would only get you about 0.25 gram per day, and most Americans don't even eat that much."

Omega-3 fatty acids are highest in fatty fish such as salmon, sardines, mackerel, herring, lake trout and albacore tuna. The AHA recommends eating two servings of fish per week to help reduce heart disease and stroke risk. It issued a science advisory in 2019 saying prescription fish oil supplements were a safe and effective way to lower triglycerides. The same advisory warned consumers not to take unregulated supplements.

A separate AHA science advisory issued in 2017 said omega-3 fish oil supplements may slightly lower the risk of dying after heart failure or a recent heart attack, but they do not prevent heart disease. Kris-Etherton co-authored both advisories.

"What I'm excited about is we're finding interventions that benefit cognitive function as we age," she said.

Kris-Etherton would like to see a similar study in older adults without heart disease to see if the supplements would provide a similar or greater benefit to others as they age. "Stay tuned," she said. "These are very interesting findings."

Find more news from Scientific Sessions.

If you have questions or comments about this story, please email editor@heart.org.

 

Friday, August 2, 2019

Should you be taking an omega-3 supplement?

I do even though I usually get two servings of salmon a week. Don't follow me, your doctor should know more about this than I do. 

Should you be taking an omega-3 supplement?

The answer to that question is becoming clearer, thanks to new research.


Some 10% of American adults regularly take an omega-3 supplement, despite uncertainty about whether these products truly live up to their health claims. But two new studies published in November 2018 shed some light on who might benefit from omega-3 supplements — and who probably won't.

VITAL

The first study was the Vitamin D and Omega-3 Trial (VITAL), a large multiyear study with 25,871 healthy adults with no history of cardiovascular (heart or blood vessel–related) disease and at "usual risk" for it. The group was racially diverse and chosen to be representative of the general population, says the study's lead author Dr. JoAnn E. Manson, professor of medicine and the Michael and Lee Bell Professor of Women's Health at Harvard Medical School.
Researchers tested, among other things, whether a moderate dosage (1 gram a day) of an omega-3 supplement could help prevent major cardiovascular events, compared with a placebo. Cardiovascular events included not only heart attacks, but stroke, and angioplasty procedures to clear blocked arteries.(Oh god, completely out-of-date.

The WHO reclassified stroke in 2006, now a neurological disease not a cardiovascular disease.)


"The findings are somewhat complex and nuanced. It's not a simple yes, or no, or one-size-fits-all answer. Some groups tended to benefit, while other groups didn't," says Dr. Manson.
Although a daily 1-gram omega-3 supplement did not significantly reduce major cardiovascular events over all, there was a 28% reduction in heart attacks and promising signals for other heart-related endpoints, she says. While the supplement didn't seem to protect most healthy people against future heart problems, certain groups did appear to benefit, particularly people who ate less than 1.5 servings of fish a week or didn't eat fish at all. "For these people, there was a significant 19% reduction in the primary endpoint of major cardiovascular events, with a 40% reduction in heart attacks," says Dr. Manson.
The supplements also appeared to benefit African American participants, who saw a 77% reduction in heart attack for those receiving the omega-3 supplement, compared with those taking the placebo, says Dr. Manson. It's unclear why this group benefited more, and additional studies are needed to confirm the finding.

REDUCE-IT

The second study, called the Reduction of Cardiovascular Events with EPA–Intervention Trial (REDUCE-IT), included more than 8,000 middle-aged and older adults who had elevated triglyceride levels and who had already experienced a cardiovascular event or had other significant risk factors for one. It aimed to find out if a daily high-dose, 4-gram prescription omega-3 medication could protect participants against future cardiovascular events, compared with a placebo. This trial, led by Dr. Deepak Bhatt, a cardiologist and professor of medicine at Harvard Medical School, found a substantial 25% reduction in the risk of dying from heart disease or suffering a cardiovascular event among people who took the medication, compared with those who had the placebo.
High doses of omega-3 supplements, like the high-dose omega-3 product used in this trial, aren't appropriate for everyone because they pose risks, such as bleeding or an increase in a type of abnormal heart rhythm known as atrial fibrillation, says Dr. Manson. "However, while high doses are associated with some risk, overall benefits of the high-dose omega-3 product used in the trial appeared to outweigh the risks for people with high triglyceride levels and a history of, or at high risk of, cardiovascular disease," says Dr. Manson.

Choosing the right supplement

Looking for an over-the-counter omega-3 supplement? Here's what to look for:
  • A 1-gram dose, unless your doctor recommends more.
  • A combination of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). Each of these fatty acids provides different health benefits.
  • A quality supplement. Good quality indicators are seals from U.S. Pharmacopeia, NSF International, or ConsumerLab.com.
If your triglyceride levels are abnormally high and you have an elevated risk for cardiovascular disease, talk to your doctor about whether a high-dose omega-3 prescription might be an option.

Putting the findings into practice

So, what do these findings mean for you?
People in good health. If you're healthy and at low or average risk for heart disease, chances are you don't need an omega-3 supplement, provided you eat fish often, says Dr. Manson. You should eat at least two servings a week of fatty fish, such as salmon, tuna, or herring. Aim for fish that are high in two different omega-3 fatty acids, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), each of which provides unique health benefits.
Getting your omega-3 fatty acids from food is always preferable to a supplement. Not only do you get the marine omega-3 fatty acids from the fish, but you also potentially replace less healthful foods in your diet, such as red meat, processed foods, or refined grains, says Dr. Manson. "It's a good lifestyle change to make and has been a recommendation for a while. Nothing in these studies supersedes the recommendation for moderate fish intake," she says.
Non–fish eaters and African Americans. However, if you can't eat fish or don't like fish, an omega-3 supplement is something to consider. (Algae-based supplements are an option if you are a vegetarian or allergic to fish.) African Americans might also consider a supplement because of the unique benefits revealed in this trial.
For these two groups, a daily 1-gram supplement could provide a good balance between safety and efficacy. "Talk to your health care provider about whether you're a candidate for a supplement," says Dr. Manson.
Already taking omega-3s? If you're already taking an over-the-counter omega-3 supplement, you don't necessarily need to stop taking it if you don't fall into one of the categories above, unless your doctor tells you to. But if you're not taking an omega-3 supplement, whether you should start really depends on your individual risk factors, says Dr. Manson.
Regardless of whether you opt for an omega-3 supplement, you should always strive to maintain a healthy diet and lifestyle. "No dietary supplement is a substitute. We already know that, and I think this is an important point to reinforce," says Dr. Manson. "Healthy lifestyle practices, including regular physical activity, healthy diet, and not smoking, will reduce heart disease risk by close to 80%, and that's really the main recommendation for heart health," she says.
Cardiovascular risk factors. If you have an elevated triglyceride level and a history of cardiovascular disease or have major risk factors for it, a high-dose omega-3 medication may be advisable. This is true even if you're already taking a statin medication. The omega-3 drug does not replace the statin.

Fast facts about the two trials

The Vitamin D and Omega-3 trial (VITAL)
This study was published online Nov. 10, 2018, by The New England Journal of Medicine.
Funding source: The U.S. National Institutes of Health.
Who: 25,871 healthy, racially diverse individuals, including 12,786 men ages 50 and older and 13,085 women ages 55 and older.
What: A daily 1-gram omega-3 prescription supplement that included a combination of two omega-3 fatty acids, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). A 1-gram dose was chosen because it is a moderate amount that is unlikely to produce side effects. A control group took a placebo.
Key takeaways:
  • Omega-3 supplements likely won't benefit people who eat at least 1.5 servings of fish per week.
  • Omega-3 supplements may benefit people with low fish consumption or those with African American heritage.
The Reduction of Cardiovascular Events with EPA–Intervention Trial (REDUCE-IT)
This study was published online Nov. 10, 2018, by The New England Journal of Medicine.
Funding source: Amarin, Inc., the company that makes the prescription-strength medication used in the study.
Who: 8,179 middle-aged men and women who had high triglyceride levels and risk factors for heart disease or had already experienced a heart attack, stroke, or cardiovascular event. Risk factors included conditions such as high blood pressure and diabetes. Everyone in the trial was taking a statin to reduce high cholesterol.
What: A daily high-dose, 4-gram prescription omega-3 medication or a placebo. Unlike over-the-counter omega-3s, the medication included EPA only.
Key takeaways: This medication may help to protect high-risk individuals from cardiovascular events. Those taking it were 25% less likely to die from heart disease or to have a heart attack, stroke, or a type of chest pain called angina. They were also less likely to need a procedure to open a blocked heart artery. If you have a high triglyceride level and have had a heart attack or stroke or have risk factors for cardiovascular disease, you might benefit from taking the high-dose omega-3 product.

Sunday, January 13, 2019

Marine n-3 polyunsaturated fatty acids and the risk of ischemic stroke

You don't want another stroke so have your doctor create a diet protocol for this.  You need to know EXACT amounts per body weight and sex. No guessing allowed.

YOUR DOCTORS' RESPONSIBILITY!

Marine n-3 polyunsaturated fatty acids and the risk of ischemic stroke

StrokeVenø SK, et al. | January 07, 2019

In this investigation, researchers tested the premise that total marine n-3 polyunsaturated fatty acids (PUFA), especially eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in diet and adipose tissue (biomarkers of long-term intake and endogenous exposure), are inversely linked to ischemic stroke risk and its subtypes. Study participants included 57,053 enrollees of the Diet, Cancer and Health cohort (aged 50-65 years). A full 1,879 participants had an ischemic stroke during 13.5 years of follow-up. Apart from cardioembolism, EPA was associated with lower risks of most types of ischemic stroke, whereas inconsistent findings were observed for total marine n-3 PUFA and DHA. The EPA content in adipose tissue was inversely linked to small-vessel occlusion.
Read the full article on Stroke

Saturday, January 5, 2019

Marine n-3 Polyunsaturated Fatty Acids and the Risk of Ischemic Stroke

Useless without giving us protocol amounts per weight and sex. And we have to figure out what EPA and DHA are. Why the fuck was this research done if not to accomplish helping those at risk for stroke? Damn it all, not your job?

Marine n-3 Polyunsaturated Fatty Acids and the Risk of Ischemic Stroke


Originally publishedhttps://doi.org/10.1161/STROKEAHA.118.023384Stroke. 2019;0:STROKEAHA.118.023384

Background and Purpose—

We hypothesized that total marine n-3 polyunsaturated fatty acids (PUFA), in particular eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in the diet and in adipose tissue (biomarkers of long-term intake and endogenous exposure) were inversely associated with the risk of ischemic stroke and its subtypes.

Methods—

The Diet, Cancer and Health cohort consisted of 57 053 participants aged 50 to 65 years at enrolment. All participants filled in a food frequency questionnaire and had an adipose tissue biopsy taken at baseline. Information on ischemic stroke during follow-up was obtained from The Danish National Patient Register, and all cases were validated. Cases and a random sample of 3203 subjects from the whole cohort had their fatty acid composition of adipose tissue determined by gas chromatography.

Results—

During 13.5 years of follow-up 1879 participants developed an ischemic stroke. Adipose tissue content of EPA was inversely associated with total ischemic stroke (hazard ratio [HR], 0.74; 95% CI, 0.62–0.88) when comparing the highest with the lowest quartile. Also, lower rates of large artery atherosclerosis were seen with higher intakes of total marine n-3 PUFA (HR, 0.69; 95% CI, 0.50–0.95), EPA (HR, 0.66; 95% CI, 0.48–0.91) and DHA (HR, 0.72; 95% CI, 0.53–0.99), and higher adipose tissue content of EPA (HR, 0.52; 95% CI, 0.36–0.76). Higher rates of cardioembolism were seen with higher intakes of total marine n-3 PUFA (HR, 2.50; 95% CI, 1.38–4.53) and DHA (HR, 2.12; 95% CI, 1.21–3.69) as well as with higher adipose tissue content of total marine n-3 PUFA (HR, 2.63; 95% CI, 1.33–5.19) and DHA (HR, 2.00; 95% CI, 1.04–3.84). The EPA content in adipose tissue was inversely associated with small-vessel occlusion (HR, 0.69; 95% CI, 0.55–0.88).

Conclusions—

EPA was associated with lower risks of most types of ischemic stroke, apart from cardioembolism, while inconsistent findings were observed for total marine n-3 PUFA and DHA.

Footnotes

Presented in part at the European Atherosclerosis Society Congress, Lisbon, Portugal, May 8, 2018.
The online-only Data Supplement is available with this article at https://www.ahajournals.org/doi/suppl/10.1161/STROKEAHA.118.023384.
Correspondence to Stine Krogh Venø, MD, Department of Cardiology, Aalborg University Hospital, Søndre Skovvej 15, 9000 Aalborg, Denmark. Email

Tuesday, June 2, 2015

Long-chain omega-3 fatty acids and the brain: a review of the independent and shared effects of EPA, DPA and DHA

You'll have to demand your doctor get a nutritionist to create a dietary stroke protocol with this in mind. And then hope like hell your doctor has enough clout to get meal services changed for survivors. OR you will need to call the hospital president for help in accomplishing it.
http://journal.frontiersin.org/article/10.3389/fnagi.2015.00052/full?
Simon C. Dyall*
  • Faculty of Health and Social Sciences, Bournemouth University, Bournemouth, UK
Omega-3 polyunsaturated fatty acids (PUFAs) exhibit neuroprotective properties and represent a potential treatment for a variety of neurodegenerative and neurological disorders. However, traditionally there has been a lack of discrimination between the different omega-3 PUFAs and effects have been broadly accredited to the series as a whole. Evidence for unique effects of eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA) and more recently docosapentaenoic acid (DPA) is growing. For example, beneficial effects in mood disorders have more consistently been reported in clinical trials using EPA; whereas, with neurodegenerative conditions such as Alzheimer’s disease, the focus has been on DHA. DHA is quantitatively the most important omega-3 PUFA in the brain, and consequently the most studied, whereas the availability of high purity DPA preparations has been extremely limited until recently, limiting research into its effects. However, there is now a growing body of evidence indicating both independent and shared effects of EPA, DPA and DHA. The purpose of this review is to highlight how a detailed understanding of these effects is essential to improving understanding of their therapeutic potential. The review begins with an overview of omega-3 PUFA biochemistry and metabolism, with particular focus on the central nervous system (CNS), where DHA has unique and indispensable roles in neuronal membranes with levels preserved by multiple mechanisms. This is followed by a review of the different enzyme-derived anti-inflammatory mediators produced from EPA, DPA and DHA. Lastly, the relative protective effects of EPA, DPA and DHA in normal brain aging and the most common neurodegenerative disorders are discussed. With a greater understanding of the individual roles of EPA, DPA and DHA in brain health and repair it is hoped that appropriate dietary recommendations can be established and therapeutic interventions can be more targeted and refined.

Lots of details at the link.

Wednesday, May 20, 2015

Omega-3 fatty acids enhance cognitive flexibility in at-risk older adults

I'm assuming this is in food not supplements. Ask your doctor for clarification. And see how long it takes for your hospital to create a dementia prevention diet protocol.
http://medicalxpress.com/news/2015-05-omega-fatty-acids-cognitive-flexibility.html
A study of older adults at risk of late-onset Alzheimer's disease found that those who consumed more omega-3 fatty acids did better than their peers on tests of cognitive flexibility—the ability to efficiently switch between tasks—and had a bigger anterior cingulate cortex, a brain region known to contribute to cognitive flexibility.
The analysis suggests, but does not prove, that consuming DHA and EPA, two omega-3 found in fish, enhanced in these adults in part by beefing up the anterior cingulate cortex, the researchers report in the journal Frontiers in Aging Neuroscience.
"Recent research suggests that there is a critical link between nutritional deficiencies and the incidence of both and degenerative neurological disorders, such as Alzheimer's disease," said University of Illinois neuroscience, psychology, and speech and hearing science professor Aron Barbey, who led the study with M.D./Ph.D. student Marta Zamroziewicz. "Our findings add to the evidence that optimal nutrition helps preserve cognitive function, slow the progression of aging and reduce the incidence of debilitating diseases in healthy aging populations."

More at link