Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Showing posts with label Dr. Michael Merzenich. Show all posts
Showing posts with label Dr. Michael Merzenich. Show all posts

Wednesday, September 28, 2016

Are You Unknowingly Contributing To Your Brain’s Decline?

From Debbie Hampton at Best Brain Possible. Shit, I just turned 60, I'm going to really have to put this stuff into high gear so I can continue to be a complete asshole to the stroke medical world.
http://www.thebestbrainpossible.com/are-you-unknowingly-contributing-to-your-brains-decline/

At around the age of 60, your brain slowly begins to shrink in volume. The cerebral cortex, responsible for most of your higher level brain function, is most affected. Many parts of the brain which support mental operation and bodily movement experience reductions. Your brain’s white matter decreases. The greatest changes take place in the areas governing thought, attention, memory, social behavior, navigation, and complex action.
In his book, Soft-Wired: How the New Science of Brain Plasticity Can Change Your Life, Dr. Michael Merzenich writes:
Which brain regions controlling which brain functions are negatively affected by age, as indexed by the status of nerve cells, the complexity of their interconnections, the chemical machinery that supports their actions, and the functions they support?’
The answer? Almost all of them.
From about age 20, your brain begins to lose neurons as part of the aging process. By age 75, nearly one-tenth of the neurons you were born with have died. While an old brain does have the ability to replace nerve cells, they die off faster than they can be replaced. (Don’t panic. The majority of brain cells survive right up until Alzheimer’s or the end of life.) The interconnections of the trillions of nerve cells left behind become progressively simplified.
Merzenich describes it like this:
The formation of connections in a young brain has been described as the construction of a complex transportation system, replete with paths, trails, byways, country roads, streets, and highways. This system sits within, and connects with, an inherited infrastructure of freeways and autobahns. In older age, our road crews are working in reverse. Paths and country roads have been ripped up, and streets and local highways are not being maintained. If we don’t do something about it soon, our excursions are going to be limited to going to only the most prominent destinations.

Why Does Your Brain Deteriorate?

According to Merzenich, there are many reasons your brain function naturally declines.

Older brains, to some extent, are just wearing out.

The ability of an older brain to sustain itself is compromised by decreased vascular supply, changes in cellular energy, nutrient sources, and immune system assets. The quality of information coming from the senses grows poorer as vision, smell, hearing, feeling, and taste degrades. Your physical body (muscles, joints, bones) is declining.

The older brain suffers from disuse.

It’s the common belief that when a person reaches their golden years, they should retire and take it easy. If someone does continue working, they have often mastered their job. In these scenarios, a person is merely operating on automatic, not learning or actively thinking, which only contributes to brain decline. You’ve got a “use it or lose it” brain. Information rarely accessed and behaviors seldom used cause a decrease in the neural pathways until connections may be completely lost.

“Negative Learning” Speeds Up Brain Decline At Any Age

From birth to death, your brain is constantly altering its physical form and function as a result of your experiences, behaviors, emotions and even thoughts. In this amazing morphing ability, known as neuroplasticity, what actually changes are the strength of the connections between neurons, synapses, that are engaged together in brain patterns. The more you repeat something, the more connections are made.
Brain plasticity is a two-way street. It’s just as easy to generate negative changes as it is positive ones. Merzenich calls backward neuroplastic change “negative learning” and writes:
It is almost just as easy to drive changes that can impair one’s memory or slow down one’s mental or physical control as it is to improve one’s memory or speed up the brain’s actions. …many older individuals are absolute masters at driving their brain plasticity in the wrong direction!
It’s not uncommon for a typical person in the U.S. to spend 50+ hours a week staring at a screen. Doing this continually narrows our field of view to a smaller box-like zone right in front of our eyes. Our brains learn to categorize everything outside of this box as a distraction not worthy of attention and get really good at filtering out anything that’s not right in front of us. By developing sustained attention in the central view, our  peripheral vision suffers, and our view of the world slowly contracts.
Millions of people have lost control of their hand function in what is known as “focal hand dystonia.” People that make repetitive hand movements, such as keyboard or mouse users, professional musicians, or assembly line workers, can lose the ability to move their fingers individually because their brains rewire neurons in the sensorimotor cortex. The problem is not in their hands, as was once believed. This condition can be helped by retraining their brains.
People who are becoming hard of hearing with age will understandably turn up the volume on their devices. By increasing the volume, they are conditioning their brains for sounds within a louder range which only contributes to further communicative loss and brain decline. Studies demonstrating sound intensity-specific plasticity show that when brains are exposed to sounds at a specific level, it ‘specializes’ for sound reception in a narrow intensive range, and degrades listening for louder or softer sounds. When you turn the volume up on the television or radio, your brain will rapidly adapt in ways that favor that volume range.

Other Habits That Harm Your Brain

Smoking – You know cigarettes cause cancer, but did you know that the nicotine in the cigarettes can shrink your brain? Many studies have shown that “tobacco smoking is associated with large-scale and wide-spread structural brain abnormalities.” Smoking thins the orbitofrontal cortex, an area of the brain associated with impulse control, reward processing, and decision making. Read more
Too Much Sugar – Overeating, poor memory formation, learning disorders, depression have all been linked to the over-consumption of sugar. Research shows that high levels of sugar reduce the brain’s ability to produce an important chemical called Brain Derived Neurotrophic Factor. BDNF helps form new memories, learn, and controls your ability to know when to stop eating. Without BDNF, you are also more susceptible to depression and dementia.
Too Little Sleep(This is me) Skimping on sleep can make you sick, fat, and stupid. Many studies have linked ongoing insufficient sleep with heart disease, diabetes, depression, early death, and a higher risk for Alzheimer’s, Parkinson’s, stroke, some cancers, and multiple sclerosis.
Loneliness(Not me)Feelings of loneliness can cause stress and inflammatory reactions in the brain. One study revealed that people had the least social contacts had the most severe cognitive deterioration.
Not Reading or Talking Enough(lots of talking, reading, not so much, no time)Reading stimulates many higher level areas of your brain and improves connectivity between brain circuits utilized. Research suggests that reading may help lower the risk of Alzheimers and dementia. Interacting with others helps maintain brain function and mental acuity. One study found that people of all ages who talked and socialized with others performed better on cognitive tests than those who didn’t talk or share their feelings as much.

Friday, September 23, 2016

Three pioneers of neuroplasticity research discuss the present and future of rewiring the brain

So I guess Norman Doige of 'The Brains's Way of Healing' and 'The Brain That Changes Itself:' isn't considered a pioneer.

But nothing in here even hints that they have any understanding of how and why a neuron will drop its existing function and take on a new one. Until that is known and repeatable will neuroplasticity truly help stroke survivors. They have lots more work to do.  

Three pioneers of neuroplasticity research discuss the present and future of rewiring the brain

A DISCUSSION WITH EVE MARDER, MICHAEL MERZENICH AND CARLA SHATZ (2016 KAVLI PRIZE IN NEUROSCIENCE):
“Our view of the brain as something constantly shaped by thought and experience is only a few decades old, yet it has profoundly influenced how we teach and treat, raise our young and care for the old.
Eve Marder, Michael Merzenich and Carla Shatz are three researchers who, in very different ways, have revealed that the brain is highly changeable, or plastic. In the course of discovering how the structure and function of brain circuits are refined, they pioneered the field of neuroplasticity…
Their work has revealed that brain circuits are “sculpted” from long before birth through adulthood. They have also helped explain how the brain achieves such a fine balance – between the adaptability that allows us to learn and to heal and the stability that maintains our abilities and memories for a lifetime.
In a roundtable, the three laureates discussed how their work disrupted a central dogma of neuroscience and offers the promise of plasticity-based therapeutics.”
Read the conversation here.
To learn more:

Monday, October 5, 2015

The 10 Fundamentals Of Rewiring Your Brain

http://www.thebestbrainpossible.com/the-10-fundamentals-of-rewiring-your-brain/
  1. Change is mostly limited to  those situations in which the brain is in the mood for it. – If you are alert, on the ball, engaged, motivated, ready for action, the brain releases the neurochemicals necessary to enable brain change. When disengaged, inattentive, distracted, or doing something without thinking that requires no real effort, your neuroplastic switches are “off.”
  2. The harder you try, the more you’re motivated, the more alert you are, and the better (or worse)  the potential outcome, the bigger the brain change. – If you’re intensely focused on the task and really trying to master something for an important reason, the change experienced will be greater.
  3. What actually changes in the brain are the strengths of the connections of neurons that are engaged together, moment by moment, in time. The more something is practised, the more connections are changed and made to include all elements of the experience (sensory info, movement, cognitive patterns). You can think of it like a “master controller” being formed for that particular behavior which allows it to be performed with remarkable facility and reliability over time.
  4. Learning-driven changes in connections increase cell-to cell cooperation which is crucial for increasing reliability. Merzenich explains this by asking you to imagine the sound of a football stadium full of fans all clapping at random versus the same people clapping in unison. He explains, “The more powerfully coordinated your [nerve cell] teams are, the more powerful and more reliable their behavioral productions.”
  5. The brain also strengthens its connections between teams of neurons representing separate moments of successive things that reliably occur in serial time. This allows your brain to predict what happens next and have a continuous “associative flow.” Without this ability, your stream of consciousness would be reduced to “a series of separate, stagnating puddles,” explains Merzenich.
  6. Initial changes are temporary. Your brain first records the change, then determines whether it should make the change permanent or not. It only becomes permanent if your brain judges the experience to be fascinating or novel enough or if the behavioral outcome is important, good or bad.
  7. The brain is changed by internal mental rehearsal in the same ways and involving precisely the same processes that control changes achieved through interactions with the external world. According to Merzenich, “You don’t have to move an inch to drive positive plastic change in your brain. Your internal representations of things recalled from memory work just fine for progressive brain plasticity-based learning.”
  8. Memory guides and controls most learning. As you learn a new skill, your brain takes note of and remembers the good attempts, while discarding the not-so-good trys. Then, it recalls the last good pass, makes incremental adjustments, and progressively improves. (If this is true then our therapists shouldn't be so insistent upon us doing things exactly correct.)
  9. Every movement of learning provides a moment of opportunity for the brain to stabilize – and reduce the disruptive power of – potentially interfering backgrounds or “noise.” Each time your brain strengthens a connection to advance your mastery of a skill, it also weakens other connections of neurons that weren’t used at that precise moment. This negative plastic brain change erases some of the irrelevant or interfering activity in the brain.
  10. Brain plasticity is a two-way street; it is just as easy to generate negative changes as it is positive ones. You have a “use it or lose it” brain. It’s almost as easy to drive changes that impair memory and physical and mental abilities as it is to improve these things. Merzenich says that older people are absolute masters at encouraging plastic brain change in the wrong direction.
More details at link.

Monday, December 9, 2013

Principles of neuroplasticity-based rehabilitation

Who is going to take these principles and create stroke protocols and distribute them to all the stroke medical personnel? Survivors are waiting right now.
http://www.ncbi.nlm.nih.gov/pubmed/24309254

Source

Brain Plasticity Institute at Posit Science Corporation, San Francisco, CA, USA; Department of Optometry, University of California, Berkeley, CA, USA.

Abstract

The purpose of this review is to summarize how our perspective about the neuroscience of brain plasticity, informed by perceptual, experimental, and cognitive psychology, has led to the designs of a new class of therapeutic tools developed to drive functionally distorted and damaged brains in corrective directions. How does neuroplasticity science inform us about optimal therapeutic program designs? How do we apply that science, using modern technology, to drive neurological changes that address both the neurobehavioral distortions and the resulting behavioral deficits that are expressed in specific neurological and psychiatric disorders? By what strategies can we achieve the strongest and most complete rehabilitative corrections? These are questions that we have extensively explored in our efforts to establish new medical applications of neuroplasticity-based therapeutics.

Here, we summarize the state of this rapidly emerging area of translational neuroscience, beginning with an explanation of the scientific premises and strategies, then describing their implementation in therapeutic software to address two human illnesses: the treatment of social cognition deficits in chronic schizophrenia and in autism; and the amelioration of age-related functional decline using strategies designed to delay the onset of-and potentially prevent-Alzheimer's Disease and related causes of dementia in aging.