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FKBP8

From Wikipedia, the free encyclopedia

FKBP8
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesFKBP8, FKBP38, FKBPr38, FK506 binding protein 8, FKBP prolyl isomerase 8
External IDsOMIM: 604840; MGI: 1341070; HomoloGene: 7720; GeneCards: FKBP8; OMA:FKBP8 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001308373
NM_012181

NM_001111066
NM_001199631
NM_010223

RefSeq (protein)

NP_001295302
NP_036313
NP_001295302.1

NP_001104536
NP_001186560
NP_034353

Location (UCSC)Chr 19: 18.53 – 18.54 MbChr 8: 70.98 – 70.99 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

FK506-binding protein 8 is a protein that in humans is encoded by the FKBP8 gene.[5][6]

The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. Unlike the other members of the family, this encoded protein does not seem to have PPIase/rotamase activity. It may have a role in neurons associated with memory function.[6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000105701Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000019428Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Lam E, Martin M, Wiederrecht G (Sep 1995). "Isolation of a cDNA encoding a novel human FK506-binding protein homolog containing leucine zipper and tetratricopeptide repeat motifs". Gene. 160 (2): 297–302. doi:10.1016/0378-1119(95)00216-S. PMID 7543869.
  6. ^ a b "Entrez Gene: FKBP8 FK506 binding protein 8, 38kDa".

Further reading

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