Assassin's Creed 2 Walkthrough

At the start of the mission, you simply need to follow the leader through the city. Do your best not to bump into anyone, as Ezio will drop the chest if you do. Eventually, you read the end of the trail and a cut scene takes over.

Now the mission gets serious. You've got to defeat Rodrigo Borgia, a feat easier said than done. In the first stage of the fight, you're best off using a sword and aggressively throwing strikes at Rodrigo. He'll naturally block most everything, and you can't get a quick kill, but you'll whittle away at his health, slowly but surely. Be ready to counter his attacks when he throws them, but if you're aggressive enough you can back Rodrigo into a corner and he won't be able to do much.

Eventually, Rodrigo calls in some backup. At this point, we suggest ditching your sword for your bare hands and using disarm techniques to defeat the opponents around you. Don't worry about attack Rodrigo—you just need to kill all of his backup to progress to the next stage of the fight. The dudes with spears are by far the most dangerous and, unless you've got a spear of your own to counter them, a disarm is the best way to take them out.

When you've defeated all of Rodrigo's men, you get some help while even more of Rodrigo's dudes show up. Again, we suggest sticking to disarms to clear the enemies, ignoring Rodrigo until all of the lesser baddies are killed. When it's just Rodrigo left, equip a sword and go back to your aggressive offense. When he's worn down, a cut scene closes out the mission.