Showing posts with label Pathology. Show all posts
Showing posts with label Pathology. Show all posts

Tuesday, October 10, 2017

Left lower lobe collapse

Left lower lobe collapse | Radiology Case | Radiopaedia.org

Presentation:
Shortness of breath.
Patient Data: Age: Adult  Gender: Female

Case courtesy of A.Prof Frank Gaillard, Radiopaedia.org. From the case rID: 7312

Wednesday, January 11, 2017

Bubonic Plague

 Wax sculpture by artist Eleanor Crook, illustrating the stages of bubonic plague. The right side of the sculpture shows the early stages, while the left shows the presentation at the late stage of the disease.

Friday, January 24, 2014

2º AV Block Mobitz Type I


Nice ilustration of second degree AV Block Mobitz type I (Wenckebach) showing the progressive PR segment prolongation until a beat is dropped due to failure of the AV node to conduct the impulse. Then the cycle is reset again given the same pattern prolonged, prolonged, prolonged, dropped.

Source: Compound Fracture, medcomic.

Monday, October 07, 2013

Restrictive lung Diseases

Explain all restrictive lung diseases.


Restrictive: interstitial problem (non-bacterial)

- Small stiff lungs (↓VC)

- Trouble breathing IN → FEV1/FVC >0.8

- ABG: ↓pO2 → ↑RR, ↓pCO2, ↑pH

- CXR: reticulo-nodular pattern, ground-glass appearance

- Die of cor pulmonale

- Ex: NM dz (breathing out is passive), drugs, autoimmune dz

- Tx: Pressure support on ventilator, ↑O2, ↑RR, ↑inspiratory time



Obstrucrive Lung Diseases

Obstructive: airway problem (bacterial)

• Big mucus-filled lungs (RV, Reid index = airway thickness/airway lumen)

•Trouble breathing out → FEV1/FVC < 0.8

• ABG: pC02 → RR, pH

• Die of bronchiectasis

Ex: COPD

Tx: Manipulate rate on ventilator  RR expiratory time, O2 only if needed.
 

Monday, December 10, 2012

Vascullitic disorders


Disorder
Vasculitis
Epidemiology/Etiology
Clinical/Laboratory Findings
Takayasu's arteritis ("pulseless disease")
Granulomatous large vessel vasculitis involving aortic arch vessels
Young Asian women and children
Absent upper extremity pulse
Visual defects, stroke
Giant cell (temporal) arteritis
Granulomatous large vessel vasculitis involving superficial temporal and ophthalmic arteries; thrombi contain microabscesses
Adults > 50 years of age
Temporal headache, jaw claudication (pain when chewing)
Blindness on ipsilateral side
Polymyalgia rheumatica (muscle and joint pain; normal serum creatine kinase)
Increased ESR
Polyarteritis nodosa
Necrotizing medium-sized vessel vasculitis involving renal, coronary, mesenteric arteries (spares pulmonary arteries)
Middle-aged men
Association with HBsAg (30%)
Vessels at all stages of acute and chronic inflammation
Focal vasculitis produces aneurysms (detected with angiography)
Organ infarction in kidneys (renal failure), heart (acute MI), bowels (bloody diarrhea), skin (ischemic ulcer)
Kawasaki disease
Necrotizing medium-sized vessel vasculitis involving coronary arteries (e.g., thrombosis, aneurysms)
Children < 4 years of age
Desquamating rash, swelling of hands and feet, cervical adenopathy, oral erythema
Abnormal ECG (e.g., acute MI)
Corticosteroids contraindicated (danger of vessel rupture)
Thromboangiitis obliterans (Buerger's disease)
Medium-sized vessel vasculitis with digital vessel thrombosis
Men 25-50 years of age who smoke cigarettes
Foot claudication, Raynaud's phenomenon, ulceration, gangrene
Raynaud's disease
Medium-sized vessel vasculitis involving digital vessels in fingers and toes
Young women
Exaggerated vasomotor response to cold or stress
Paroxysmal digital color changes (white-blue-red sequence)
Ulceration and gangrene in chronic cases
Raynaud's phenomenon
Medium-sized vessel vasculitis involving digital vessels in fingers and toes
Adult men and women
Secondary to other diseases (e.g., systemic sclerosis, CREST syndrome)
Systemic sclerosis and CREST syndrome: digital vasculitis with vessel fibrosis, dystrophic calcification, ulceration, gangrene
Wegener's granulomatosis
Necrotizing medium-sized and small vessel vasculitis involving upper respiratory tract, lung, renal vessels
Childhood to middle age
Necrotizing vasculitis in upper respiratory tract (nasopharynx, sinuses, trachea), lower respiratory tract (pulmonary vessels; infarction, pneumonia), kidneys (crescentic glomerulonephritis)
Necrotizing granulomas in upper respiratory tract (saddle nose deformity), lungs c-ANCA antibodies (>90% of cases)
Treatment: corticosteroids, cyclophosphamide
Microscopic polyangiitis
Small vessel vasculitis involving skin, lung, brain, GI tract, and postcapillary venules and glomerular capillaries
Children and adults
Precipitated by drugs (e.g., penicillin), infections (e.g., streptococci), immune disorders (e.g., SLE)
Vessels at same stage of inflammation
Palpable purpura, glomerulonephritis p-ANCA antibodies (>80% of cases)
Churg-Strauss syndrome
Small vessel vasculitis involving skin, lung, heart vessels
Children and adults
Allergic rhinitis, asthma
p-ANCA antibodies (70% of cases), eosinophilia
Henoch-Schönlein purpura
Small vessel vasculitis involving skin, GI tract, renal, joint vessels
Children and young adults
Most common vasculitis in children
IgA immunocomplexes
Palpable purpura of buttocks and lower extremities
Polyarthritis, glomerulonephritis, GI bleeding
Cryoglobulinemia
Small vessel vasculitis involving skin, GI tract, renal vessels
Adults
Association with HCV, type I MPGN
Cryoglobulins: immunoglobulins that gel at cold temperatures
Palpable purpura, acral cyanosis of nose and ears and Raynaud's phenomenon (reverses when in warm room)
Serum sickness
Small vessel vasculitis involving immunocomplex deposition in skin vessels
Children and adults
Complication of treatment of rattlesnake envenomation with horse-or sheep-based antivenin
Fever, urticaria with vasculitis, arthralgia, GI pain with melena
Infectious vasculitis
Small vessel vasculitis involving skin vessels
Children and adults
Involves all microbial pathogens
Rocky Mountain spotted fever: tick transmission of Rickettsia rickettsiae; organisms invade endothelial cells; petechiae on palms spread to trunk
Disseminated meningococcemia due to Neisseria meningitidis
Capillary thrombosis produces hemorrhage into skin and confluent ecchymoses

Friday, December 07, 2012

Takayasu's arteritis


Disorder
Vasculitis
Epidemiology/Etiology
Clinical/Laboratory Findings
Takayasu's arteritis ("pulseless disease")
Granulomatous large vessel vasculitis involving aortic arch vessels
Young Asian women and children
Absent upper extremity pulse
Visual defects, stroke

File:Takayasu Arteritis.jpg
Source Goljan, Wikipedia

Temporal Arteritis


Disorder
Vasculitis
Epidemiology/Etiology
Clinical/Laboratory Findings
 
 
 
 
Giant cell (temporal) arteritis
Granulomatous large vessel vasculitis involving superficial temporal and ophthalmic arteries; thrombi contain microabscesses
Adults > 50 years of age
Temporal headache, jaw claudication (pain when chewing)
Blindness on ipsilateral side
Polymyalgia rheumatica (muscle and joint pain; normal serum creatine kinase)
Increased ESR
Temporal Arteritis