(a) Interpretation: The activation of pyruvate carboxylase by acetyl-CoA should be explained. Concept introduction: The co-operative interaction where the binding of one molecule of a substance influences the binding of next molecules of the same kind is described to as a homotopic allosteric interaction; similarly, a heterotopic allosteric interaction involves the co-operative interaction among the different type of substances binding with a target protein.

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Answer 1

Question

Chapter 13, Problem 9P

Interpretation Introduction

(a) Interpretation:

The activation of pyruvate carboxylase by acetyl-CoA should be explained.

Concept introduction:

The co-operative interaction where the binding of one molecule of a substance influences the binding of next molecules of the same kind is described to as a homotopic allosteric interaction; similarly, a heterotopic allosteric interaction involves the co-operative interaction among the different type of substances binding with a target protein.

Interpretation Introduction

(b) Interpretation:

The activation of pyruvate dehydrogenase kinase by NADH should be explained.

Concept introduction:

The co-operative interaction where the binding of one molecule of a substance influences the binding of next molecules of the same kind is described to as a homotopic allosteric interaction; similarly, a heterotopic allosteric interaction involves the co-operative interaction among the different type of substances binding with a target protein.

Interpretation Introduction

(c) Interpretation:

The inhibition of isocitrate dehydrogenase by NADH should be explained.

Concept introduction:

The co-operative interaction where the binding of one molecule of a substance influences the binding of next molecules of the same kind is described to as a homotopic allosteric interaction; similarly, a heterotopic allosteric interaction involves the co-operative interaction among the different type of substances binding with a target protein.

Interpretation Introduction

(d) Interpretation:

The activation of isocitrate dehydrogenase by ADP should be explained.

Concept introduction:

The co-operative interaction where the binding of one molecule of a substance influences the binding of next molecules of the same kind is described to as a homotopic allosteric interaction; similarly, a heterotopic allosteric interaction involves the co-operative interaction among the different type of substances binding with a target protein.

Interpretation Introduction

(e) Interpretation:

The inhibition of α -ketoglutarate dehydrogenase by succinyl-CoA should be explained.

Concept introduction:

The co-operative interaction where the binding of one molecule of a substance influences the binding of next molecules of the same kind is described to as a homotopic allosteric interaction; similarly, a heterotopic allosteric interaction involves the co-operative interaction among the different type of substances binding with a target protein.

Interpretation Introduction

(f) Interpretation:

The activation of pyruvate dehydrogenase phosphatase by Ca²+ should be explained.

Concept introduction:

The co-operative interaction where the binding of one molecule of a substance influences the binding of next molecules of the same kind is described to as a homotopic allosteric interaction; similarly, a heterotopic allosteric interaction involves the co-operative interaction among the different type of substances binding with a target protein.

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Answer 2

Question

Chapter 13, Problem 9P

Interpretation Introduction

(a) Interpretation:

The activation of pyruvate carboxylase by acetyl-CoA should be explained.

Concept introduction:

The co-operative interaction where the binding of one molecule of a substance influences the binding of next molecules of the same kind is described to as a homotopic allosteric interaction; similarly, a heterotopic allosteric interaction involves the co-operative interaction among the different type of substances binding with a target protein.

Interpretation Introduction

(b) Interpretation:

The activation of pyruvate dehydrogenase kinase by NADH should be explained.

Concept introduction:

The co-operative interaction where the binding of one molecule of a substance influences the binding of next molecules of the same kind is described to as a homotopic allosteric interaction; similarly, a heterotopic allosteric interaction involves the co-operative interaction among the different type of substances binding with a target protein.

Interpretation Introduction

(c) Interpretation:

The inhibition of isocitrate dehydrogenase by NADH should be explained.

Concept introduction:

The co-operative interaction where the binding of one molecule of a substance influences the binding of next molecules of the same kind is described to as a homotopic allosteric interaction; similarly, a heterotopic allosteric interaction involves the co-operative interaction among the different type of substances binding with a target protein.

Interpretation Introduction

(d) Interpretation:

The activation of isocitrate dehydrogenase by ADP should be explained.

Concept introduction:

The co-operative interaction where the binding of one molecule of a substance influences the binding of next molecules of the same kind is described to as a homotopic allosteric interaction; similarly, a heterotopic allosteric interaction involves the co-operative interaction among the different type of substances binding with a target protein.

Interpretation Introduction

(e) Interpretation:

The inhibition of α -ketoglutarate dehydrogenase by succinyl-CoA should be explained.

Concept introduction:

The co-operative interaction where the binding of one molecule of a substance influences the binding of next molecules of the same kind is described to as a homotopic allosteric interaction; similarly, a heterotopic allosteric interaction involves the co-operative interaction among the different type of substances binding with a target protein.

Interpretation Introduction

(f) Interpretation:

The activation of pyruvate dehydrogenase phosphatase by Ca²+ should be explained.

Concept introduction:

The co-operative interaction where the binding of one molecule of a substance influences the binding of next molecules of the same kind is described to as a homotopic allosteric interaction; similarly, a heterotopic allosteric interaction involves the co-operative interaction among the different type of substances binding with a target protein.

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Answer 3

Question

Chapter 13, Problem 9P

Interpretation Introduction

(a) Interpretation:

The activation of pyruvate carboxylase by acetyl-CoA should be explained.

Concept introduction:

The co-operative interaction where the binding of one molecule of a substance influences the binding of next molecules of the same kind is described to as a homotopic allosteric interaction; similarly, a heterotopic allosteric interaction involves the co-operative interaction among the different type of substances binding with a target protein.

Interpretation Introduction

(b) Interpretation:

The activation of pyruvate dehydrogenase kinase by NADH should be explained.

Concept introduction:

The co-operative interaction where the binding of one molecule of a substance influences the binding of next molecules of the same kind is described to as a homotopic allosteric interaction; similarly, a heterotopic allosteric interaction involves the co-operative interaction among the different type of substances binding with a target protein.

Interpretation Introduction

(c) Interpretation:

The inhibition of isocitrate dehydrogenase by NADH should be explained.

Concept introduction:

The co-operative interaction where the binding of one molecule of a substance influences the binding of next molecules of the same kind is described to as a homotopic allosteric interaction; similarly, a heterotopic allosteric interaction involves the co-operative interaction among the different type of substances binding with a target protein.

Interpretation Introduction

(d) Interpretation:

The activation of isocitrate dehydrogenase by ADP should be explained.

Concept introduction:

The co-operative interaction where the binding of one molecule of a substance influences the binding of next molecules of the same kind is described to as a homotopic allosteric interaction; similarly, a heterotopic allosteric interaction involves the co-operative interaction among the different type of substances binding with a target protein.

Interpretation Introduction

(e) Interpretation:

The inhibition of α -ketoglutarate dehydrogenase by succinyl-CoA should be explained.

Concept introduction:

The co-operative interaction where the binding of one molecule of a substance influences the binding of next molecules of the same kind is described to as a homotopic allosteric interaction; similarly, a heterotopic allosteric interaction involves the co-operative interaction among the different type of substances binding with a target protein.

Interpretation Introduction

(f) Interpretation:

The activation of pyruvate dehydrogenase phosphatase by Ca²+ should be explained.

Concept introduction:

The co-operative interaction where the binding of one molecule of a substance influences the binding of next molecules of the same kind is described to as a homotopic allosteric interaction; similarly, a heterotopic allosteric interaction involves the co-operative interaction among the different type of substances binding with a target protein.

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Answer 4

Question

Chapter 13, Problem 9P

Interpretation Introduction

(a) Interpretation:

The activation of pyruvate carboxylase by acetyl-CoA should be explained.

Concept introduction:

The co-operative interaction where the binding of one molecule of a substance influences the binding of next molecules of the same kind is described to as a homotopic allosteric interaction; similarly, a heterotopic allosteric interaction involves the co-operative interaction among the different type of substances binding with a target protein.

Interpretation Introduction

(b) Interpretation:

The activation of pyruvate dehydrogenase kinase by NADH should be explained.

Concept introduction:

The co-operative interaction where the binding of one molecule of a substance influences the binding of next molecules of the same kind is described to as a homotopic allosteric interaction; similarly, a heterotopic allosteric interaction involves the co-operative interaction among the different type of substances binding with a target protein.

Interpretation Introduction

(c) Interpretation:

The inhibition of isocitrate dehydrogenase by NADH should be explained.

Concept introduction:

The co-operative interaction where the binding of one molecule of a substance influences the binding of next molecules of the same kind is described to as a homotopic allosteric interaction; similarly, a heterotopic allosteric interaction involves the co-operative interaction among the different type of substances binding with a target protein.

Interpretation Introduction

(d) Interpretation:

The activation of isocitrate dehydrogenase by ADP should be explained.

Concept introduction:

The co-operative interaction where the binding of one molecule of a substance influences the binding of next molecules of the same kind is described to as a homotopic allosteric interaction; similarly, a heterotopic allosteric interaction involves the co-operative interaction among the different type of substances binding with a target protein.

Interpretation Introduction

(e) Interpretation:

The inhibition of α -ketoglutarate dehydrogenase by succinyl-CoA should be explained.

Concept introduction:

The co-operative interaction where the binding of one molecule of a substance influences the binding of next molecules of the same kind is described to as a homotopic allosteric interaction; similarly, a heterotopic allosteric interaction involves the co-operative interaction among the different type of substances binding with a target protein.

Interpretation Introduction

(f) Interpretation:

The activation of pyruvate dehydrogenase phosphatase by Ca²+ should be explained.

Concept introduction:

The co-operative interaction where the binding of one molecule of a substance influences the binding of next molecules of the same kind is described to as a homotopic allosteric interaction; similarly, a heterotopic allosteric interaction involves the co-operative interaction among the different type of substances binding with a target protein.

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Answer 5

Chapter 13, Problem 9P

Interpretation Introduction

(a) Interpretation:

The activation of pyruvate carboxylase by acetyl-CoA should be explained.

Concept introduction:

The co-operative interaction where the binding of one molecule of a substance influences the binding of next molecules of the same kind is described to as a homotopic allosteric interaction; similarly, a heterotopic allosteric interaction involves the co-operative interaction among the different type of substances binding with a target protein.

Interpretation Introduction

(b) Interpretation:

The activation of pyruvate dehydrogenase kinase by NADH should be explained.

Concept introduction:

The co-operative interaction where the binding of one molecule of a substance influences the binding of next molecules of the same kind is described to as a homotopic allosteric interaction; similarly, a heterotopic allosteric interaction involves the co-operative interaction among the different type of substances binding with a target protein.

Interpretation Introduction

(c) Interpretation:

The inhibition of isocitrate dehydrogenase by NADH should be explained.

Concept introduction:

The co-operative interaction where the binding of one molecule of a substance influences the binding of next molecules of the same kind is described to as a homotopic allosteric interaction; similarly, a heterotopic allosteric interaction involves the co-operative interaction among the different type of substances binding with a target protein.

Interpretation Introduction

(d) Interpretation:

The activation of isocitrate dehydrogenase by ADP should be explained.

Concept introduction:

The co-operative interaction where the binding of one molecule of a substance influences the binding of next molecules of the same kind is described to as a homotopic allosteric interaction; similarly, a heterotopic allosteric interaction involves the co-operative interaction among the different type of substances binding with a target protein.

Interpretation Introduction

(e) Interpretation:

The inhibition of α -ketoglutarate dehydrogenase by succinyl-CoA should be explained.

Concept introduction:

The co-operative interaction where the binding of one molecule of a substance influences the binding of next molecules of the same kind is described to as a homotopic allosteric interaction; similarly, a heterotopic allosteric interaction involves the co-operative interaction among the different type of substances binding with a target protein.

Interpretation Introduction

(f) Interpretation:

The activation of pyruvate dehydrogenase phosphatase by Ca²+ should be explained.

Concept introduction:

The co-operative interaction where the binding of one molecule of a substance influences the binding of next molecules of the same kind is described to as a homotopic allosteric interaction; similarly, a heterotopic allosteric interaction involves the co-operative interaction among the different type of substances binding with a target protein.

Answer 6

Chapter 13, Problem 9P

Interpretation Introduction

(a) Interpretation:

The activation of pyruvate carboxylase by acetyl-CoA should be explained.

Concept introduction:

The co-operative interaction where the binding of one molecule of a substance influences the binding of next molecules of the same kind is described to as a homotopic allosteric interaction; similarly, a heterotopic allosteric interaction involves the co-operative interaction among the different type of substances binding with a target protein.

Answer 7

Chapter 13, Problem 9P

Interpretation Introduction

(a) Interpretation:

The activation of pyruvate carboxylase by acetyl-CoA should be explained.

Concept introduction:

The co-operative interaction where the binding of one molecule of a substance influences the binding of next molecules of the same kind is described to as a homotopic allosteric interaction; similarly, a heterotopic allosteric interaction involves the co-operative interaction among the different type of substances binding with a target protein.

Answer 8

Interpretation Introduction

(b) Interpretation:

The activation of pyruvate dehydrogenase kinase by NADH should be explained.

Concept introduction:

The co-operative interaction where the binding of one molecule of a substance influences the binding of next molecules of the same kind is described to as a homotopic allosteric interaction; similarly, a heterotopic allosteric interaction involves the co-operative interaction among the different type of substances binding with a target protein.

Answer 9

Interpretation Introduction

(b) Interpretation:

The activation of pyruvate dehydrogenase kinase by NADH should be explained.

Concept introduction:

The co-operative interaction where the binding of one molecule of a substance influences the binding of next molecules of the same kind is described to as a homotopic allosteric interaction; similarly, a heterotopic allosteric interaction involves the co-operative interaction among the different type of substances binding with a target protein.

Answer 10

Interpretation Introduction

(c) Interpretation:

The inhibition of isocitrate dehydrogenase by NADH should be explained.

Concept introduction:

The co-operative interaction where the binding of one molecule of a substance influences the binding of next molecules of the same kind is described to as a homotopic allosteric interaction; similarly, a heterotopic allosteric interaction involves the co-operative interaction among the different type of substances binding with a target protein.

Answer 11

Interpretation Introduction

(c) Interpretation:

The inhibition of isocitrate dehydrogenase by NADH should be explained.

Concept introduction:

The co-operative interaction where the binding of one molecule of a substance influences the binding of next molecules of the same kind is described to as a homotopic allosteric interaction; similarly, a heterotopic allosteric interaction involves the co-operative interaction among the different type of substances binding with a target protein.

Answer 12

Interpretation Introduction

(d) Interpretation:

The activation of isocitrate dehydrogenase by ADP should be explained.

Concept introduction:

The co-operative interaction where the binding of one molecule of a substance influences the binding of next molecules of the same kind is described to as a homotopic allosteric interaction; similarly, a heterotopic allosteric interaction involves the co-operative interaction among the different type of substances binding with a target protein.

Answer 13

Interpretation Introduction

(d) Interpretation:

The activation of isocitrate dehydrogenase by ADP should be explained.

Concept introduction:

The co-operative interaction where the binding of one molecule of a substance influences the binding of next molecules of the same kind is described to as a homotopic allosteric interaction; similarly, a heterotopic allosteric interaction involves the co-operative interaction among the different type of substances binding with a target protein.

Answer 14

Interpretation Introduction

(e) Interpretation:

The inhibition of α -ketoglutarate dehydrogenase by succinyl-CoA should be explained.

Concept introduction:

The co-operative interaction where the binding of one molecule of a substance influences the binding of next molecules of the same kind is described to as a homotopic allosteric interaction; similarly, a heterotopic allosteric interaction involves the co-operative interaction among the different type of substances binding with a target protein.

Answer 15

Interpretation Introduction

(e) Interpretation:

The inhibition of α -ketoglutarate dehydrogenase by succinyl-CoA should be explained.

Concept introduction:

The co-operative interaction where the binding of one molecule of a substance influences the binding of next molecules of the same kind is described to as a homotopic allosteric interaction; similarly, a heterotopic allosteric interaction involves the co-operative interaction among the different type of substances binding with a target protein.

Answer 16

Interpretation Introduction

(f) Interpretation:

The activation of pyruvate dehydrogenase phosphatase by Ca²+ should be explained.

Concept introduction:

The co-operative interaction where the binding of one molecule of a substance influences the binding of next molecules of the same kind is described to as a homotopic allosteric interaction; similarly, a heterotopic allosteric interaction involves the co-operative interaction among the different type of substances binding with a target protein.

Answer 17

Interpretation Introduction

(f) Interpretation:

The activation of pyruvate dehydrogenase phosphatase by Ca²+ should be explained.

Concept introduction:

The co-operative interaction where the binding of one molecule of a substance influences the binding of next molecules of the same kind is described to as a homotopic allosteric interaction; similarly, a heterotopic allosteric interaction involves the co-operative interaction among the different type of substances binding with a target protein.

Answer 18

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Answer 19

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Answer 20

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Answer 21

Ch. 13 - Prob. 1P Ch. 13 - Prob. 2P Ch. 13 - Suppose that aconitase did not bind its substrate...Ch. 13 - Prob. 4P Ch. 13 - Prob. 5P Ch. 13 - Prob. 6P Ch. 13 - Prob. 7P Ch. 13 - Prob. 8P Ch. 13 - Prob. 9P Ch. 13 - Prob. 10P

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