Abstract
Divergence in antigen response of the immune network is discussed, based on shape-space modelling. The present model extends the shape-space model by introducing the evolution of specificity of idiotypes. When the amount of external antigen increases, stability of the immune network changes and the network responds to the antigen. It is shown that specific and non-specific responses emerge as a function of antigen levels. A specific response is observed with a fixed point attractor, and a non-specific response is observed with a long-lived chaotic transient state of the lymphocyte population dynamics. The network topology also changes between these two states. The relevance of such a long-lived transient state is discussed with respect to immune function.
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References
Ghosh, S., Campbell, A.M.; Immunology today. 7 (1986) 217–222
Kearney, J.M., Vakil, M., Nicholson, N.; Evolution and Vertebrate Immunity. G. Kelose and D. Schulze Eds. Texas University Press, Austin. (1987) 175–190
Wedemayer, G.J., et al.; Science. 276 (1997) 1665–1669
Jerne, N.K.; Ann.Immunol. 125C (1974) 373–389
Segel, L.A., Perelson, A.S.; Theoretical Immunology edited by Perelson, A.S. Addison-Wesley Pub.Company (1987) 321–344
Kaneko, K. Phys.Lett. 149 A (1990) 105–112
Bersini, H., Calender, N.; J.theor.Biol. 188 (1997) 187–200
Calenbuhr, V., Bersini. H., Stewart, J., Valera, F.J.; J.theor.biol. 177 (1995) 199–213
Detoures, V., Bersini, H., Stewart, J., Varela, F.J.; J.theol.Biol. 170 (1994) 401–414
Stewart, J. et al.; J.Autoimmune. 2 (1989) 15–23
Harada, K., Ikegami, T.; submitted to J.theol.Biol (1998)
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Harada, K., Ikegami, T. (1999). Evolution of Multispecificity in an Immune Network. In: Floreano, D., Nicoud, JD., Mondada, F. (eds) Advances in Artificial Life. ECAL 1999. Lecture Notes in Computer Science(), vol 1674. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-48304-7_59
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DOI: https://doi.org/10.1007/3-540-48304-7_59
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