Short chain fatty acids produced by anaerobic bacteria inhibit adhesion and proliferation of periodontal ligament fibroblasts.
Department of Cell Biology, Forsyth Dental Center, Boston.
Short chain fatty acids (SCFA) are metabolic
by-products of anaerobic bacteria present in the periodontal pocket. We
examined the effect of SCFA on cultured human periodontal ligament
fibroblasts (PDLF). PDLF were challenged with propionate, butyrate and
succinate. A dose dependent inhibition of fibroblast adhesion and
proliferation was observed. These results indicate that SCFA present in
the periodontal pockets could interfere with periodontal wound healing
and repair in patients affected by periodontal infections.
PMID: 8164622 [PubMed - indexed for MEDLINE]
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