TCB Publications - Abstract
Hui Lu and Klaus Schulten. Steered molecular dynamics simulations of force-induced protein domain unfolding. PROTEINS: Structure, Function, and Genetics, 35:453-463, 1999.
-sandwich domains, exhibits nanasecond (ns) unfolding only after a force above 1500 pN is applied; the second type, arising in a wider class of protein domain structures, requires significantly weaker forces for ns unfolding. In the first case, strong forces are needed to concertedly break a set of interstrand hydrogen bonds which protect the domains against unfolding through stretching; in the second case, stretching breaks backbone hydrogen bonds stabilizing the structure one by one, and does not require strong forces for this purpose. Stretching of -sandwich (immunoglobulin) domains has been investigated further revealing a specific relationship between response to mechanical strain and the architecture of -sandwich domains. Download Full Text
The manuscripts available on our site are provided for your personal use only and may not be retransmitted or redistributed without written permissions from the paper's publisher and author. You may not upload any of this site's material to any public server, on-line service, network, or bulletin board without prior written permission from the publisher and author. You may not make copies for any commercial purpose. Reproduction or storage of materials retrieved from this web site is subject to the U.S. Copyright Act of 1976, Title 17 U.S.C.
