TCB Publications - Abstract

TCB Publications - Abstract

C Keith Cassidy, Benjamin A Himes, Zaida Luthey-Schulten, and Peijun Zhang. CryoEM-based hybrid modeling approaches for structure determination. Current Opinion in Microbiology, 43:14-23, 2018. (PMC: PMC5934336)

CASS2018-ZLS Recent advances in cryo-electron microscopy (cryoEM) have dramatically improved the resolutions at which vitrified biological specimens can be studied, revealing new structural and mechanistic insights over a broad range of spatial scales. Bolstered by these advances, much effort has been directed toward the development of hybrid modeling methodologies for the construction and refinement of high-fidelity atomistic models from cryoEM data. In this brief review, we will survey the key elements of cryoEM-based hybrid modeling, providing an overview of available computational tools and strategies as well as several recent applications.

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