Search Results (5,166)

In this manuscript, we will discuss the solutions of Goursat problems with fuzzy boundary conditions involving gH-differentiability. The solutions to these problems face two main challenges. The first challenge is to deal with the two types of fuzzy gH-differentiability: $\left(i\right)$-differentiability and $\left(ii\right)$-differentiability. The sign of coefficients in Goursat problems and gH-differentiability produces sixteen possible cases. The existing literature does not afford a solution method that addresses all the possible cases of this problem. The second challenge is the mixed derivative term in Goursat problems with fuzzy boundary conditions. Therefore, we propose to discuss the solutions of fuzzy Goursat problems with gH-differentiability. We will discuss the solutions of fuzzy Goursat problems in series form with natural transform and Adomian decompositions. To demonstrate the usability of the established solution methods, we will provide some numerical examples. Full article

Objectives: Our aim was to study how hemodialysis patients with varying levels of literacy would use a diet and fluid intake monitoring mobile application (DIMA-P) and what would be its impact on their dietary behaviors. Materials and Methods: We developed a mobile application using user-centered methods and informed by the Integrated Theory of Health Behavior Change (ITHBC). Eight hemodialysis patients were recruited to use the application to record and monitor their diet and fluid intakes for a 6-week study. Overall, the participants had low literacy, numeracy, and technical skills. We collected the data on application usage and administered usability and context-of-use questionnaires to gain insights into the participants’ interaction with the application. The participants’ portion estimation skills and dietary self-regulation self-efficacy were assessed using various tests. In addition, interdialytic weight gain data were collected to assess the impact of app usage on the participants’ health outcomes. Results: The application usage patterns varied, with a general trend towards frequent use (n = 5) correlating with engagement in self-monitoring. The participants gave high comprehensibility, user-friendliness, satisfaction, and usefulness ratings, suggesting that the app was well designed and the target users could easily navigate and interact with the features. While the participants improved in estimating portion sizes, the impact on measuring skills was variable. There was also an improvement in the participants’ dietary self-regulation self-efficacy post-study. The interdialytic weight gain trends indicated a slight improvement in fluid and diet management. Conclusion: People with different literacy skills can effectively use icon-based interfaces for portion size estimation and develop personalized usage patterns to self-regulate their fluid and dietary intakes. Moreover, they can experience an enhancement in their dietary self-efficacy skills by using a mobile application aimed at providing nutritional feedback. Furthermore, this research shows that the constructs of the ITHBC are effective in promoting dietary behavior change in a population with varying literacy skills. The target users can benefit from explicitly visualizing the relationship between their health outcomes and the factors influencing those outcomes. These user ambitions could be supported by developing machine learning models. Future research should also focus on enhancing the mechanisms by which technology can further enhance each component of the ITHBC framework. Full article

The electroencephalogram (EEG) is a cornerstone tool for the diagnosis, management, and prognosis of selected patient populations. EEGs offer significant advantages such as high temporal resolution, real-time cortical function assessment, and bedside usability. The quantitative EEG (qEEG) added the possibility of long recordings being processed in a compressive manner, making EEG revision more efficient for experienced users, and more friendly for new ones. Recent advancements in commercially available software, such as Persyst, have significantly expanded and facilitated the use of qEEGs, marking the beginning of a new era in its application. As a result, there has been a notable increase in the practical, real-world utilization of qEEGs in recent years. This paper aims to provide an overview of the current applications of qEEGs in daily neurological emergencies and ICU practice, and some elementary principles of qEEGs using Persyst software in clinical settings. This article illustrates basic qEEG patterns encountered in critical care and adopts the new terminology proposed for spectrogram reporting. Full article

(1) Background: The influence of robotic therapy on patients with sub-acute cervical spinal cord injury (SCI) for improving their activities of daily living (ADL) performance is unclear; (2) Methods: 31 subjects with cervical SCI completed the training randomly assigned to an intervention or control group during 40 sessions. All the subjects received, in each session, 30 min of upper-extremity conventional therapy. In addition, the subjects within the control group received another 30 min of conventional therapy, whereas subjects within the intervention group received 30 min of robotic therapy with Armeo Spring (Hocoma AG, Volketswil, Switzerland). Therefore, the ADL of drinking was trained by using the exoskeleton. Feasibility and efficacy measurements as clinical scales and kinematic indices, and usability questionnaires, were used as assessment at baseline and at the ending of the study (week 10); (3) Results: The intervention group significantly improved with regards to the feeding and grooming items of the Spinal Cord Independence Measure scale. The improvement in the movement smoothness related to the activity of drinking was greater in the intervention group than in the control (p = 0.034); (4) Conclusions: The findings of this study reveal that patients with cervical SCI improve their performance in ADL with robotic therapy. Full article

The rapidly growing field of cannabinoid research is gaining recognition for its impact in neuropsychopharmacology and mood regulation. However, prenyltransferase (NphB) (a key enzyme in cannabinoid precursor synthesis) still needs significant improvement in order to be usable in large-scale industrial applications due to low activity and limited product range. By rational design and high-throughput screening, NphB’s catalytic efficiency and product diversity have been markedly enhanced, enabling direct production of a range of cannabinoids, without the need for traditional enzymatic conversions, thus broadening the production scope of cannabinoids, including cannabigerol (CBG), cannabigerolic acid (CBGA), cannabigerovarin (CBGV), and cannabigerovarinic acid (CBGVA). Notably, the W3 mutant achieved a 10.6-fold increase in CBG yield and exhibited a 10.3- and 20.8-fold enhancement in catalytic efficiency for CBGA and CBGV production, respectively. The W4 mutant also displayed an 9.3-fold increase in CBGVA activity. Molecular dynamics simulations revealed that strategic reconfiguration of the active site’s hydrogen bonding network, disulfide bond formation, and enhanced hydrophobic interactions are pivotal for the improved synthetic efficiency of these NphB mutants. Our findings advance the understanding of enzyme optimization for cannabinoid synthesis and lay a foundation for the industrial-scale production of these valuable compounds. Full article

As voice user interfaces (VUIs) rapidly transform the landscape of human–computer interaction, their potential to revolutionize user engagement is becoming increasingly evident. This paper aims to advance the field of human–computer interaction by conducting a bibliometric analysis of the user experience associated with VUIs. It proposes a classification framework comprising six research categories to systematically organize the existing literature, analyzes the primary research streams, and identifies future research directions within each category. This systematic literature review provides a comprehensive analysis of the development and effectiveness of VUIs in facilitating natural human–machine interaction. It offers critical insights into the user experience of VUIs, contributing to the refinement of VUI design to optimize overall user interaction and satisfaction. Full article

Power distribution of progressive power lenses provides usable regions based on power distribution analysis. However, recent studies demonstrated that these regions are not always used for certain tasks as predicted. This work determines the concordance between the actual region of lens use and compares it with the theoretically located regions. The pupil position of 26 subjects was recorded using an eye-tracking system (Tobii-Pro-Glasses 3) at distance and near-reading tasks while wearing a general use progressive power lens. Subjects were asked to read aloud a text showed on a screen placed at 5.25 m and 37 cm while looking though the central and lateral regions of the lens. The pupil position was projected onto the back surface of the lens to obtain the actual region of use for each fixation. Results showed that the actual region of use matched with the theoretically located. On average, the concordance between the actual and theoretical regions of use was 85% for a distance-reading task and 73% for a near-reading task. In conclusion, the proposed method effectively located the actual regions of the lens used, revealing how users’ posture affects lens usage. This insight enables the design of more customized progressive lenses based on the areas used during vision-based tasks. Full article

Telerehabilitation can be a valuable addition to conventional rehabilitation after a stroke. The aim of the presented study was to assess the feasibility and integrability of a newly developed platform and service model to offer telerehabilitation in different settings in an initial field trial. The field trial was conducted in two clinics and a freelance therapy setting in Austria and Slovenia. Data were gathered using questionnaires for patients, therapists, and, if applicable, relatives. The data were analyzed using descriptive methods. Three patients were treated by seven therapists (occupational, physio, speech). During the test, the patients completed more than 25 exercises per week on average. The usability of the system, in general, was high, with slightly better results for the patients. Overall, the patients stated that telerehabilitation is a good addition to conventional therapy, although the quality of online therapy is not as high as face-to-face therapy. The therapists reported that the system was easy to use but had some obstacles in exercise preparation. The integrability in daily life was good, according to the patients. For the therapists, integrability was average, as the test showed some obstacles in the provision of services beyond the clinical setting. Further studies are required to elaborate on the quality of teletherapeutic interventions in the proposed flexible service model. Full article

The evolution of cartography poses challenges in representing three-dimensional terrain accurately on traditional two-dimensional maps. Providing an accurate 3D view of the area, coupled with essential geographic information, is vital for rapid and accurate decision-making in emergency management and response. Holography offers a promising solution by providing immersive three-dimensional visualizations. The field of hologram mapping, although novel, is still developing. Given its nascent stage, several limitations are evident. This study addresses one such limitation—inaccuracies in distance measurement—by presenting a hologram map that integrates two-dimensional and three-dimensional information. Accurate distance information on maps is critical for operational success. We aimed to improve hologram maps by integrating contour lines. Our approach allows users to measure distances from near-perpendicular angles while viewing 3D features from other perspectives. We review current advancements in hologram mapping, highlight existing limitations, and introduce our innovative solution designed to enhance both accuracy and usability. Our experiment resulted in a hologram map that accurately depicts a 3D environment, integrates contour lines, and allows for distance and slope angle measurements. The hologram map fills the research gap by providing accurate 3D visualization and distance measurement, signifying a major advancement in hologram mapping. Full article

The energy sector is a critical contributor to the growth and development of any country’s economy. However, ensuring robust cybersecurity within the context of smart energy services presents persistent usability challenges in an increasingly digital environment. This study explores the intersection of human-computer interaction (HCI), cybersecurity, and usability to identify and address issues that impact the overall security of smart energy management systems. By analyzing the complex relationships between users and security protocols, this research aims to enhance the security framework, promote better user adherence, and improve system usability. The study focuses on three primary objectives: (1) identifying the most prevalent usability issues in current cybersecurity practices; (2) examining the relationship between HCI and user compliance with security measures; and (3) proposing strategies to improve cybersecurity usability by leveraging HCI principles. Hybrid approaches utilizing artificial intelligence facilitate empirical analysis and framework evaluation. Additionally, a comparative study with six existing models has been conducted. By envisioning a future where security measures not only ensure enhanced protection but also integrate seamlessly into user experiences, this approach seeks to provide valuable insights into ongoing cybersecurity discussions and contribute to a more resilient security landscape against evolving digital threats. Full article

Background/Objectives: Adeno-associated viruses (AAVs) are widely used as viral vectors for gene delivery in mammalian cells. We focused on the efficacy of the transduction of AAV2/5, 2/6, 2/8 and 2/9 expressing GFP in preadipocyte cells by live imaging microscopy using IncuCyte S3 and flow cytometry. Methods: Three transduction modes in 3T3-L1 preadipocyte cells assessed: AAV transduction in 3T3-L1 preadipocyte cells, transduction with further differentiation into mature adipocyte-like cells and the transduction of differentiated 3T3-L1 adipocytes. For the in vivo study, we injected AAV2/6, AAV2/8 and AAV2/9 in adipose tissue of C57BL6 mice, and the transduction capacity of AAV2/6, along with AAV2/8 and AAV2/9 was evaluated. Results: AAV2/6 demonstrated the highest transduction efficiency in 3T3-L1 preadipocytes, as it was 1.5–2-fold more effective than AAV2/5, and AAV2/8 in the range of viral concentrations from 2 × 10⁴ to 1.6 × 10⁵ VG/cell. AAV2/5 and AAV2/8 showed transduction efficiencies similar to each other. The expression of GFP under the CMV promoter remained stable for up to 20 days. The induction of 3T3-L1 differentiation in three days after AAV transduction did not alter the GFP expression level, and AAV2/6 showed the best transduction efficiency. AAV2/6 demonstrated the ability to transduce mature adipocytes. These results were confirmed by in vivo studies on C57BL6 mice. AAV2/6 had the highest transducing activity on both inguinal and interscapular adipose tissue. Conclusions: Thus, AAV2/6 has demonstrated higher transduction efficacy compared to AAV2/5, AAV2/8 and AAV2/9 both in 3T3-L1 adipocytes and adipose tissue in vivo, which proves its usability along with AAV2/8 and AAV2/9 for gene delivery to adipocytes. Full article

In this study, the feasibility of using ceramic wastes in the production of blended cement was evaluated by substituting limestone with ceramic waste at the percentages of 5, 10, 15, 20, and 28% before the milling stage. The chemical, physical, and mechanical properties of the cements were determined according to relevant standards, and the results were compared. The chemical analysis showed that the SiO₂ content of the cements increased with higher ceramic waste substitution percentages, while the CaCO₃ content decreased. The grindability of cements decreased with increased ceramic waste ratios, slightly reducing the Blaine specific surface area values. The water consistency for the cements was set at 28%, and all the cements met the standard limitations. The spread diameters for all types of cements were similar and practically usable in terms of workability. The cements containing ceramic waste either maintained or extended the setting time. All cements with ceramic waste exhibited higher flexural and compressive strength compared to the reference cement. The highest flexural strengths were achieved with a 28% ceramic waste substitution ratio across all curing ages. Regarding compressive strengths, all cements exhibited higher compressive strength than 10 MPa at 2 days and 32.5 MPa at 28 days, classifying them as 32.5 R-type blended cements. When the medium- (56–90 days) and long-term (365 days) compressive strengths were compared, the highest strength values were obtained from the cement with a 28% ceramic waste substitution. Although limestone-blended cement is emerging as a promising alternative to traditional Portland cement, these types of cement still contribute to environmental degradation due to the extraction of natural limestone resources through quarrying. This study showed that blended cements can be produced using ceramic waste, providing a more sustainable and environmentally friendly solution for the construction industry. Full article

This paper presents a concomitant observer-based multi-level fault-tolerant control (FTC) for near-space vehicles (NSVs) with a new type dissimilar redundant actuation system (NT-DRAS). When NSV flight control system faults occur in NT-DRAS and attitude-corresponding sensors, the NSV hybrid output states, including the concomitant observer usable states and the real system states, are applied to solve the FTC gain by using the linear quadratic regulator (LQR) technique. Furthermore, since NT-DRAS is used in NSVs, a multi-level (actuation system level and flight control level) FTC strategy integrating NT-DRAS channel switching and flight control LQR is proposed for complex and worsening fault cases. The most important finding is that though the proposed strategy is applicable for worsening fault cases in NSVs, systematic and accurate criteria for the process being performed are necessary and can improve the FTC efficiency with minimal FTC resources. Additionally, such criteria can improve the NSV’s responsiveness to comprehensive faults, provided that the real-time performance of the fault detection and diagnosis (FDD) scheme can be further optimized. The concomitant observer convergence and the multi-level FTC strategy have been verified by numerical simulations based on the Matlab/Simulink platform. Full article

Background: This research aims to evaluate the usability of the HyperArc (HA) technique in stereotactic radiosurgery for cervical spine metastasis by comparing the dosimetry of the target and organs at risk, specifically the spinal cord, between HA and VMAT and conventional volumetric modulated arc therapy (VMAT). Methods: A RANDO^® phantom and QFix Encompass^TM and support system were used to simulate three target types (A, B, and C) based on RTOG0631 guidelines. Treatment plans included one VMAT and two HyperArc techniques with different SRS NTO values (100 and 250). Dosimetric parameters such as conformity index (CI), homogeneity index (HI), R₅₀, and spinal cord sparing were analyzed. Gamma analysis was performed using portal dosimetry to validate the dose delivery accuracy. Results: HyperArc plans demonstrated higher conformity, sharper dose fall-off, and improved quality assurance (QA) results compared to VMAT plans. HA with SRS NTO 250 showed even better results in terms of conformity, dose fall-off, and spinal cord dose reduction (V₁₀ and D_max) compared to HA with SRS NTO 100. Although the mean gamma passing rates were slightly lower, all plans achieved rates above 95%. Conclusion: The findings suggest that HA provides superior dosimetric benefits over VMAT and could be effectively utilized for cervical spine radiation therapy. Full article

Skilled programmers are in high demand, and a critical obstacle to satisfying this demand is the difficulty of acquiring programming skills. This issue can be addressed with automated assessment, which gives fast feedback to students trying to code, and gamification, which motivates them to intensify their learning efforts. Although some collections of gamified programming exercises are available, producing new ones is very demanding. This paper presents GAMAI, an AI-powered exercise gamifier, enriching the Framework for Gamified Programming Education (FGPE) ecosystem. Leveraging large language models, GAMAI enables teachers to effortlessly apply storytelling to describe a gamified scenario, as GAMAI decorates natural language text with the sentences needed by OpenAI APIs to contextualize the prompt. Once a gamified scenario has been generated, GAMAI automatically produces exercise files in a FGPE-compatible format. According to the presented evaluation results, most gamified exercises generated with AI support were ready to be used, with no or minimum human effort, and were positively assessed by students. The usability of the software was also assessed as high by the users. Our research paves the way for a more efficient and interactive approach to programming education, leveraging the capabilities of advanced language models in conjunction with gamification principles. Full article