Search Results (927)

Aim: The primary endothelial NADPH oxidase isoform 4 (NOX4) is notably induced during hypoxia, with emerging evidence suggesting its vasoprotective role through H₂O₂ production. Therefore, we aimed to elucidate NOX4′s significance in endothelial function under hypoxia. Methods: Human vessels, in addition to murine vessels from Nox4^-/- mice, were explored. On a functional level, Mulvany myograph experiments were performed. To obtain mechanistical insights, human endothelial cells were cultured under hypoxia with inhibitors of hypoxia-inducible factors. Additionally, endothelial cells were cultured under combined hypoxia and laminar shear stress conditions. Results: In human occluded vessels, NOX4 expression strongly correlated with prostaglandin I2 synthase (PTGIS). Hypoxia significantly elevated NOX4 and PTGIS expression and activity in human endothelial cells. Inhibition of prolyl hydroxylase domain (PHD) enzymes, which stabilize hypoxia-inducible factors (HIFs), increased NOX4 and PTGIS expression even under normoxic conditions. NOX4 mRNA expression was reduced by HIF1a inhibition, while PTGIS mRNA expression was only affected by the inhibition of HIF2a under hypoxia. Endothelial function assessments revealed hypoxia-induced endothelial dysfunction in mesenteric arteries from wild-type mice. Mesenteric arteries from Nox4^-/- mice exhibited an altered endothelial function under hypoxia, most prominent in the presence of cyclooxygenase inhibitor diclofenac to exclude the impact of prostacyclin. Restored protective laminar shear stress, as it might occur after thrombolysis, angioplasty, or stenting, attenuated the hypoxic response in endothelial cells, reducing HIF1a expression and its target NOX4 while enhancing eNOS expression. Conclusion: Hypoxia strongly induces NOX4 and PTGIS, with a close correlation between both factors in occluded, hypoxic human vessels. This relationship ensured endothelium-dependent vasodilation under hypoxic conditions. Protective laminar blood flow restores eNOS expression and mitigates the hypoxic response on NOX4 and PTGIS. Full article

Thermal energy is very crucial, and Phase Change Materials (PCM) provide methods to store it. The objective of this study is to investigate the effect of changing the angle of the Latent Thermal Energy Storage Unit (LTESU) on the amount of time required to melt the PCM. Stearic acid (PCM) was enclosed in a housing to subject it to thermal energy at different orientations. Changing the angle enhances the buoyancy force exerted on melted PCM as thermal energy is added, causing a difference in density. This density difference produces flow currents that circulate the melted PCM in the enclosure due to the hot PCM rising and surrounding the cold PCM that occupies the space left by the hot PCM. These currents are responsible for the distribution of thermal energy throughout the enclosure so that naturally turbulent flow will transfer more heat energy as compared to laminar flow. It was noted that the least amount of time needed to charge the stearic acid was at 60°. An improvement of 16.67% in terms of melting time was observed with respect to the reference case. Full article

Background: In the research of coronary artery disease, the precise initial injury that starts the atherosclerotic cascade remains unidentified. Moreover, the mechanisms governing the progression or regression of coronary plaque are not yet fully understood. Based on the concept that the cardiovascular system is a network of pumps and pipes, could fluid mechanics principles and practices elucidate the question of atherosclerosis using flow dynamics images from a novel angiographic technique, focusing on antegrade and retrograde flows and their collisions in iliac and coronary arteries? Methods: From January 2023 to May 2024, coronary angiograms of all hemodynamically stable patients with stable or unstable angina were screened. The angiograms displaying either no lesions (normal) or mild-to-moderate lesions were selected. Each patient underwent an evaluation of flow dynamics and arterial phenomena in both iliac and right coronary arteries. For each artery, data were categorized based on the following parameters: laminar versus non-laminar flow, presence versus absence of collisions, and presence versus absence of retrograde flow. Additionally, in two sub-studies, we analyzed the relationship between retrograde flow and blood pressure, and artificial intelligence algorithms were used to detect the retrograde flow in the right coronary artery. Results: A total of 95 patients were screened, and 51 were included in this study. The results comprised quantitative data (prevalence of laminar flows, collisions, and retrograde flows) and qualitative data (morphological characteristics of antegrade laminar flow, retrograde contrast flow, and instances of flow collision). The results showed that in the iliac artery, laminar flow was observed in 47.06% (24/51) of cases, with collisions noted in 23.53% (12/51). Retrograde flow was present in 47.06% (24/51) of cases, and notably, 75% (18/24) of these cases were associated with uncontrolled diastolic blood pressure (DBP) above 80 mmHg (p < 0.001). Conversely, in the RCA, laminar flow was observed in 54.9% (28/51) of cases, with collisions noted in only 3.92% (2/51). Retrograde flow was identified in 7.84% (4/51) of cases, and all these cases (100%, 4/4) were associated with uncontrolled systolic blood pressure (SBP) above 120 mmHg, though statistical significance was not reached due to the small sample size (p > 0.05). Conclusions: Based on the concept that the cardiovascular system is a network of pumps and pipes, this research methodology provides intriguing insights into arterial flow behaviors by integrating fluid mechanics practices with novel angiographic observations. The preliminary results of this study identified laminar flow as the predominant pattern, with retrograde flow and collisions occurring infrequently. The implications of vortex, collision, and disorganized flow highlight potential mechanisms for endothelial damage and atherosclerosis initiation. Moreover, the correlation with blood pressure underscores the critical role of hypertension management in preventing adverse hemodynamic events. Future directions include refining imaging techniques and further exploring the mechanistic links between flow dynamics and vascular pathophysiology to enhance diagnostic and therapeutic strategies for cardiovascular diseases. Full article

To study the effects of fluid compressibility on the dynamics of a cavitating vortex street flow in a regime where the vortex shedding frequency increases as a result of the cavitation increase, the cavitating wake behind a wedge was simulated employing both incompressible and compressible solvers. To do this, a compressible cavitation model was implemented, modifying the Zwart-Gerber-Belamri (ZGB) incompressible solver and including a pressure limit and absorbing boundary conditions to prevent a non-physical pressure field. To validate the performance of the compressible model, preliminary simulations were carried out on a 1D Sod cavitating tube and the cavitating vortex shedding behind a circular body at laminar flow conditions. The results of the cavitating wake behind the wedge with the incompressible and the compressible solvers showed similar predictions in terms of pressure, vortex shedding frequency, and instantaneous and average vapor volume fraction profiles. In spite of this, differences were obtained in the energy content of the fluid force fluctuations on the body at higher frequencies, which appear to be better resolved and amplified when the compressibility model is considered. Overall, both solvers provided comparable results in terms of cavitation phenomena that are well aligned with experimental observations. Full article

The determination of the characteristics and main combustion properties of fuels is necessary for post-implementation in different applications. Among the most important combustion properties of a fuel are the combustion products, flame temperature and laminar burning velocity. Therefore, this paper describes the step-by-step development and coding of a MATLAB application that can determine 12 combustion products, flame temperature and laminar burning velocity in order to understand the logic of calculus procedure, so any user would be able to make improvements of new functionalities (add more fuels, add more combustion products, etc.). The numerical procedure and methods (Gaussian elimination, Taylor Series and Newton–Raphson) parallel with their implementation as code lines for the development of the application are carried out using flow charts. In addition, simulations in Ansys Chemkin were performed and included in the application as part of the results comparison. It was found that: (1) The MATLAB Application codification and development were successfully explained in detail, (2) the functions and execution sequence are described by using flow charts and code extract, (3) the application is available to everyone for modifications, (4) the application can only be used for hydrocarbons fuels, (5) the application execution time registered was less than 8 s. Full article

This study delves into the convective heat transfer phenomena within a square cavity that houses a porous medium, analyzing the effects of Darcy (Da) and Rayleigh (Ra) numbers on the thermal and fluid dynamic behavior within the system. Utilizing a combination of computational fluid dynamics (CFD) and the finite element method (FEM), the research focuses on steady-state, laminar flow conditions in two dimensions. The cavity, which is impermeable at its boundaries, contains a centrally located square region filled with a porous, isotropic material. The thermal environment is controlled with insulated horizontal walls and vertically positioned walls that experience sinusoidal temperature variations. The study examines how variations in the permeability of the porous medium (Da numbers ranging from 10⁻¹ to 10⁻⁴) and the buoyancy-driven flow strength (Ra numbers spanning from 10² to 10⁵) influence the velocity fields and heat transfer rates, with results expressed through Nusselt number (Nu) distributions. The findings reveal that higher Ra numbers, particularly at 10⁵, significantly intensify convection within the cavity, thereby boosting local rates of heat transfer, especially in the central vertical section. The research identifies that optimal flow resistance in the porous medium occurs within the Da number range of 10⁻³ to 10⁻⁴. These insights are critical for advancing thermal management techniques, particularly in the natural cooling of electronic devices and improving insulation methods. Full article

In this study, a single-outer-spiral electrode with inductance of 20 μH is employed to couple the energy input of a bipolar nanosecond pulse for the purpose of generating a large-scale atmospheric pressure plasma jet. When the spiral electrode is wrapped around a plasma jet tube with a length of 35 cm, the electrical field can be optimized, resulting in a stable laminar flow field, and a plasma jet with a length and diameter larger than 14 cm and 1.2 cm can be generated. A comparative study of the bipolar and unipolar pulse excitation voltages is also conducted, showing that the maximum lengths of the plasma jet excited by a bipolar pulse voltage, positive pulse voltage, and negative are 14 cm, 10 cm, and 7 cm, respectively. The temporal and spatially resolved spectra of the plasma jets excited by both bipolar and unipolar pulses are investigated, respectively, and the main physiochemical processes of the active species and the plasma dynamics’ evolution are discussed. Full article

There is a prevailing consensus that most Computational Fluid Dynamics (CFD) frameworks can accurately predict global variables under laminar flow conditions within the Food and Drug Administration (FDA) benchmark nozzle geometry. However, variations in derived variables, such as strain rate and vorticity, may arise due to differences in numerical solvers and gradient evaluation methods, which can subsequently impact predictions related to blood damage and non-Newtonian flow behavior. To examine this, flow symmetry indices, vortex characteristics, and blood damage—were assessed using Newtonian and four non-Newtonian viscosity models with CFD codes Ansys Fluent and OpenFOAM on identical meshes. At Reynolds number (Re) 500, symmetry breakdown and complex vortex shapes were predicted with some non-Newtonian models in both OpenFOAM and Ansys Fluent, whereas these phenomena were not observed with the Newtonian model. This contradicted the expectation that employing a non-Newtonian model would delay the onset of turbulence. Similarly, at Re 2000, symmetry breakdown occurred sooner (following the sudden expansion section) with the non-Newtonian models in both Ansys Fluent and OpenFOAM. Vortex identification based on the Q-criterion resulted in distinctly different vortex shapes in Ansys Fluent and OpenFOAM. Blood damage assessments showed greater prediction variations among the non-Newtonian models at lower Reynolds numbers. Full article

Hybrid Laminar Flow Control (HLFC) is a promising technology for reducing aircraft drag and, therefore, emissions and fuel consumption. The integration of HLFC systems within the small space of the wing leading edge, together with de-icing and high lift systems, is one of the main challenges of this technology. This challenge can be tackled by using microholes along the outer skin panels to control suction without the need for an internal chamber. However, microperforations modify the mechanical properties of titanium sheets, which bring new challenges in terms of wing manufacturability. These modified properties create uncertainty that must be investigated. The present paper studies the mechanical properties of micro-drilled titanium grade 2 sheets and their modeling using the Finite Element Method (FEM). First, an experimental campaign consisting of tensile and Nakajima tests is conducted. Then, an FEM model is developed to understand the role of the anisotropy in sheet formability. The anisotropy ratios are found by combination of Design of Experiments (DoE) and the Response Surface Method (RSM); these ratios are as follows: 1.050, 1.320, and 0.975 in the directions Y, Z, and XY, respectively. Some mechanical properties are affected by the presence of microholes, especially the elongation and formability that are significantly reduced. The reduction in elongation depends on the orientation: 20% in longitudinal, 17% in diagonal, and 31% in transversal. Full article

Pipe bends disrupt the flow, resulting in an asymmetric velocity field across the pipe diameter (D). We examined the recovery length required for the flow to return to a symmetric velocity profile downstream of a sharp elbow. The wall-resolved Large Eddy Simulation (LES) approach was applied to reproduce turbulent fluid flow at Reynolds numbers ($Re$) of 5600 and 10,000. An additional case in the transitional laminar-turbulent-laminar regime was analyzed at $Re=1400$. This analysis explored the behavior of the Dean vortices downstream of the elbow and revealed that, in turbulent cases, these vortices reverse their vorticity direction in the region between 8 D and 10 D. However, they eventually decay in structure as far as 25 D from the elbow. Flow asymmetry was analyzed in a 100 D long pipe section downstream of the elbow using four different criteria: wall shear stress (WSS), streamwise velocity, its fluctuations, and vorticity fields. This study found that in turbulent flows, the distance required for flow recovery is a few tens of D and decreases with increasing $Re$. However, in the transitional case, the flow separation within the elbow induces instabilities that gradually diminish downstream, and flow asymmetry persists even longer than the 100 D length of our outlet pipe section. WSS proved sensitive for detecting asymmetry near walls, whereas flow profiles better revealed bulk asymmetry. It was also shown that asymmetry indicators derived from velocity fluctuations and vorticity were less sensitive than those obtained from streamwise velocity. Full article

To achieve high-fidelity large eddy simulation (LES) predictions of complex flows while keeping computational costs manageable, this study integrates a high-order WENO-ZQ scheme into the LES framework. The WENO-ZQ scheme has been extensively studied for its accuracy, robustness, and computational cost in inviscid flow applications. This study extended the WENO-ZQ scheme to viscous flows by integrating it into a three-dimensional structured grid LES CFD solver. High-fidelity simulations of turbulent boundary layer flow and supersonic compression ramp flows were conducted, with the scheme being applied for the first time to study laminar boundary layer transition and separation flows in the high-load, low-pressure turbine PakB cascade. Classic numerical case validations for viscous conditions demonstrate that the WENO-ZQ scheme, compared to the same-order WENO-JS scheme, exhibits lower dispersion and dissipation errors, faster convergence, and better high-frequency wave resolution. It maintains high-resolution accuracy with fewer grid points. In application cases, the WENO-ZQ scheme accurately captures the three-dimensional flow characteristics of shockwave–boundary layer interactions in supersonic compression ramps and shows high accuracy and resolution in predicting separation and separation-induced transition in low-pressure turbines. Full article

The formation of soot and NOx in ammonia/ethylene flames with varying ammonia ratios was investigated through experimental and numerical analysis. The spatial distribution of the soot volume fraction and NOx concentrations along the flame central line were measured, and the mechanism of soot and NOx formation during ammonia/ethylene co-combustion was analyzed using CHEMKIN 17.0. The experimental results indicated that the soot volume fraction decreases with an increase in ammonia ratio, with the soot peak concentration occurring in the upper region of the flame. The distribution of NOx is complex. In the initial part of the flame, a higher concentration of NOx is generated, and the lower the ammonia ratio, the higher the concentration of NOx. As the combustion process progresses, the concentration of NOx initially decreases and then subsequently increases rapidly, with higher ammonia ratios leading to higher concentrations of NOx. The addition of ammonia results in a decrease in CH₃, C₂H₂, and C₃H₃, and an increase in CN concentration. This leads to a transformation of carbon atoms within the combustion system, reducing the available carbon for soot formation and suppressing its generation. A higher ammonia ratio increases the likelihood that NH₃ will be oxidized to N₂, as well as increasing the probability that any generated NO will undergo reduction to N₂ through the action of the free radicals NH₂ and NH. Full article

Due to the extremely low Reynolds number, the mixing of substances in laminar flow within microfluidic channels primarily relies on slow intermolecular diffusion, whereas various rapid reaction and detection requirements in lab-on-a-chip applications often necessitate the efficient mixing of fluids within short distances. This paper presents a magnetic pillar-shaped particle fabrication device capable of producing particles with planar shapes, which are then utilized to achieve the rapid mixing of multiple fluids within microchannels. During the particle fabrication process, a degassed PDMS chip provides self-priming capabilities, drawing in a UV-curable adhesive-containing magnetic powder and distributing it into distinct microwell structures. Subsequently, an external magnetic field is applied, and the chip is exposed to UV light, enabling the mass production of particles with specific magnetic properties through photo-curing. Without the need for external pumping, this chip-based device can fabricate hundreds of magnetic particles in less than 10 min. In contrast to most particle fabrication methods, the degassed PDMS approach enables self-priming and precise dispensing, allowing for precise control over particle shape and size. The fabricated dual-layer magnetic particles, featuring fan-shaped blades and disk-like structures, are placed within micromixing channels. By manipulating the magnetic field, the particles are driven into motion, altering the flow patterns to achieve fluid mixing. Under conditions where the Reynolds number in the chip ranges from 0.1 to 0.9, the mixing index for substances in aqueous solutions exceeds 0.9. In addition, experimental analyses of mixing efficiency for fluids with different viscosities, including 25 wt% and 50 wt% glycerol, reveal mixing indices exceeding 0.85, demonstrating the broad applicability of micromixers based on the rapid rotation of magnetic particles. Full article

Numerical techniques have been developed to study flow structures in the wake behind a tapered circular cylinder via computational fluid dynamics. The Reynolds number, based on the mean diameter of the tapered cylinder, is 4 × 10³; here, the boundary layer on the cylinder surface is laminar before separating into a turbulent wake. In order to model this transient turbulent flow, a large eddy simulation was adopted and vortex-shedding frequencies were determined using the fast Fourier transform. The fundamental behaviors of the cellular distributions of vortex-shedding frequencies, mechanisms of vortex splitting and the vortex cell reorganization were addressed. Two constant-frequency vortex cells were observed in the operating Reynolds number, and the respective Strouhal numbers were validated experimentally. Numerical flow visualizations showed that the spanwise shedding vortices are well aligned, whereas the vortex splitting seems to disconnect vortex lines. The pressure coefficients at specific zones and angular positions of the tapered cylinder were illustrated to explore the correlation of pressure variation with vortex shedding. The results showed that the vortex splitting initiates and completes at boundary-layer separation. Furthermore, numerical techniques are elaborated on for readers to tackle similar problems. Full article

The newly developed computational fluid dynamics, transport, and chemical kinetics-based monolith catalyst dimensioning methodology consists of the following steps: (i) initial calculations, which generate some of the data, e.g., average inlet fluid velocity used in the (ii) computational fluid dynamics (CFD) modelling, which uses the laminar flow interface and the transport of diluted species interface while the user has to provide the kinetics of the reactions; (iii) the model order reduction uses a modified version of the plug flow reactor model and the linear pressure variation model; and (iv) the dimensioning optimization algorithm extracts the optimal monolith catalyst’s channel geometry, which satisfies the user’s performance constraints and reduces material consumption. Therefore, the methodology enables chemical engineers to quickly and efficiently design and dimension monolith catalysts for many different applications in an environmentally friendly way, which enables them to reduce both the material and operating costs while maintaining sufficient catalyst performance and, therefore, achieve its cost-effective performance. Full article