Biotage’s Post

#Pala #SingleCellDispenser from #biotechne: The Pala Single Cell Dispenser is your benchtop analytical partner for single cell sorting. No matter what cell type you are working with, get single cells dispensed directly into your 96- or 384-well plates, all under 7 minutes! By combining proprietary microfluidics, flow cytometry, and liquid dispensing technologies, this benchtop single cell sorter automates and simplifies single cell isolation across various applications: Cell line development,  Cell engineering,  Single cell genomics,  Monoclonal antibody development,  Synthetic biology, Rare cell isolation such as circulating tumor cells (CTCs) and circulating fetal cells (CFCs). The Pala Single Cell Dispenser is affordable, easy-to-use, very low maintenance, and requires no complicated training to operate! Check out more here and get in contact: https://lnkd.in/ep9vZA5J #biotechne #singlecell #celllinedevelopment #rarecells #cellsorting #Pala

Are you attending #CEBioForum2024? Don't miss the chance to meet Dr. Tomasz Rygiel, Chief Scientific Officer at Cellis. Dr. Rygiel will be available to discuss our breakthrough platform technology, the Macrophage Drug Conjugate (MDC), for the treatment of solid tumors. Drop a comment below to schedule a meeting with Dr. Rygiel or simply connect! #CEBioForum #Warsaw #Biotechnology #CancerTreatment #MacrophageDrugConjugate #ClinicalTrials

Last week, we were honored to welcome Professor Emeritus Yechezkel Barenholz, an expert in drug delivery and a co-inventor of #Doxil®, a liposomal formulation of doxorubicin used for cancer treatment. Together with him, our team co-authored the study “Quantitative Cryo-TEM Reveals New Structural Details of Doxil-Like PEGylated Liposomal Doxorubicin Formulation” (https://lnkd.in/d8xWFgXP). This study demonstrates that cryo-TEM (cryogenic transmission electron microscopy), combined with advanced image analysis, can successfully determine multiple structural parameters of complex liposomal nano-drugs, providing statistically-sound data   QuTEM offers detailed TEM-analysis of circularity, lamellarity, membrane thickness, integrity, aggregation, vector content, and morphological assessment, along with custom classification, helping customers to gain insights on product stability, drug release efficiency or product potency for example. #TEM #QuTEM #Liposome #innovation  https://lnkd.in/d8xWFgXP

🌟 Friday Read: Accelerating Drug Development with Spatial Biology 👉https://bit.ly/4aro6Lo Presage Biosciences, Inc.'s CIVO® platform, combined with GeoMx and CosMx technologies, effectively tracks anti-neoplastic and immune-modulating activity in the intact tumor microenvironment. This innovative approach is speeding up drug development and paving the way for more successful clinical trials.🔬 #SpatialBiology #DrugDevelopment #FridayRead This post may include information regarding CosMx™ SMI products for RNA detection, which products are not available in the Federal Republic of Germany, as further described here - https://lnkd.in/gUXh88Pr.

Let's explore the Nanotechnology sector as we spotlight the top organisations making waves last year * Seer - Leading the charge with the Proteograph™ Product Suite, Seer, Inc. is revolutionising our understanding and approach to proteomics. * Aera Therapeutics - With its groundbreaking protein nanoparticle (PNP) delivery platform, Aera Therapeutics is harnessing new funding to redefine the possibilities of genetic medicine. * Nutcracker Therapeutics - an early-stage biotech company, is reimagining cancer treatment through its pioneering mRNA technologies, promising a new era of healthcare solutions. These leaps signal a future where technology elevates patient care to unprecedented heights. This insight is just a snippet of our extensive 2023 Advanced Technology Market Analysis. Find the full report download link in the comments. #NanoScience #PatientCare #TechTrends

Abstract submission deadline for RICT 2024 is May 14! Submit your abstracts for poster presentation on the following topics: - Chemistry in Living Systems and Chemical Biology - Induced Proximity Including Degraders - Next Generation Cancer Therapeutics - New Modalities for Drug Discovery - Enabling Technologies - Recent Trends in Neurodegenerative Diseases Drug Development - First Disclosures of Clinical Candidates and Cases Studies - Breakthroughs in Deep Learning, CryoEM and their Impact on Drug Discovery A limited number of grants will be funded by the SCT and Corporate Sponsors to support the participation of young academic scientists presenting a poster at the conference. Find out more on www.rict2024.org/grants Register and submit your abstract on https://lnkd.in/emdk7JYN #MedChem #MedicinalChemistry #DrugDiscovery

Join us and take a deep dive into biophysical screening approaches including case studies, fragment-based approaches and covalent hit identification

🔍PI3Kα-IN-22 is a potent WT-sparing, PI3Kα(H1047R) inhibitor, designed to target specific mutations, which serves as a driver oncogene in certain cancers. This particular compound was recently highlighted by the Drug Hunter. ✅We have selected a set of PI3Kα inhibitor analogs that are readily available to enrich your research. Check them out here: https://lnkd.in/euVjXZty ✅Also, we at Chemspace provide comprehensive Discovery Solutions! We will navigate you through accessible chemical space using our computational approaches to identify new chemotypes for the target of interest. Chemspace – your end-to-end Discovery CRO 💚 https://buff.ly/3KoEKAF #chemspace #openscience #research #science #drugdiscovery #chemicals #medicinalchemistry #drugdevelopment #chemistry #researchanddevelopment #search #chemicalindustry #science #structures

Biodistribution and function of coupled polymer-DNA origami nanostructures Researchers have developed nanoscale agents, formed from a hybrid of polymer and DNA origami, demonstrating stability in serum and controlled tissue diffusion. The agents, stable for over five days post-injection, were functionalized with aptamers targeting tumor necrosis factor TNF-alpha, showing a significant reduction in inflammatory response in a humanized TNF-alpha mouse model. This approach offers spatial control over drug distribution, potentially minimizing adverse effects. The programmable nature of polymer-DNA hybrid nanostructures presents a novel avenue for drug control, akin to monoclonal antibodies but with added spatial precision. Read more: https://lnkd.in/d_D_KtVZ #dna #medical #genetic #biotechnology #biomedical

a nice commentary paper(#doi: 10.1038/s41565-024-01637-x )on our study (# doi: 10.1038/s41565-024-01624-2 )The concept we'd like to share with the community is exactly >To think beyond conventional nanoscale design paradigms & more deeply into how to better control the cell biology that underlies responses to emerging therapeutics.