Protein disulfide topology determination through the fusion of mass spectrometric analysis and sequence-based prediction using Dempster-Shafer theory
R Singh, W Murad - BMC bioinformatics, 2013 - Springer
Background Disulfide bonds constitute one of the most important cross-linkages in proteins
and significantly influence protein structure and function. At the state-of-the-art, various
methodological frameworks have been proposed for identification of disulfide bonds. These
include among others, mass spectrometry-based methods, sequence-based predictive
approaches, as well as techniques like crystallography and NMR. Each of these frameworks
has its advantages and disadvantages in terms of pre-requisites for applicability, throughput …
and significantly influence protein structure and function. At the state-of-the-art, various
methodological frameworks have been proposed for identification of disulfide bonds. These
include among others, mass spectrometry-based methods, sequence-based predictive
approaches, as well as techniques like crystallography and NMR. Each of these frameworks
has its advantages and disadvantages in terms of pre-requisites for applicability, throughput …
Protein disulfide topology determination through the fusion of mass spectrometric analysis and sequence-based prediction using Dempster-Shafer theory
S Rahul, M William - 2013 - agris.fao.org
Background Disulfide bonds constitute one of the most important cross-linkages in proteins
and significantly influence protein structure and function. At the state-of-the-art, various
methodological frameworks have been proposed for identification of disulfide bonds. These
include among others, mass spectrometry-based methods, sequence-based predictive
approaches, as well as techniques like crystallography and NMR. Each of these frameworks
has its advantages and disadvantages in terms of pre-requisites for applicability, throughput …
and significantly influence protein structure and function. At the state-of-the-art, various
methodological frameworks have been proposed for identification of disulfide bonds. These
include among others, mass spectrometry-based methods, sequence-based predictive
approaches, as well as techniques like crystallography and NMR. Each of these frameworks
has its advantages and disadvantages in terms of pre-requisites for applicability, throughput …
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