
I discovered this book, For the Love of Enzymes; The Odyssey of a Biochemist, by Arthur Kornberg, by accident. I was moseying through the stacks at our university library, actually looking for something else (that happened to be checked out already) and I saw this and thought it might be an interesting read. Understatement, to say the least! As I read through this, I realized that there are probably a single handful of books (other than the scriptures) that I've read that have been life-changing, and I think that this definitely is now added to that list. I have so many pages tagged with notecards that I can hardly close the book, and is one of the very few library books that I have been sorely tempted to mark up. Needless to say, I will be buying a copy for my very own, that I can mark up as I please!
Basically, this is a memoir of Arthur Kornberg. For those who are not familiar with that name, he is a most renowned biochemist, and he won a Nobel prize in 1959 for the discovery of how to synthesize DNA in vitro.
So... why did I like this book so much? Kornberg has a very engaging manner of writing- in spite of including a fair amount of pretty in-depth biochemistry, the book was not difficult to read, and I found it quite entertaining. He talks a lot about his process of coming to study DNA synthesis- starting first as a vitamin hunter and his shift to being an enzyme hunter. He discusses the shifts in science trends from vitamins to enzymes to diseases to genes, and along with this, he includes all sorts of great stories about the famous scientists of the time. Most of these people are ones I discuss with my classes, and I'm excited to start a new semester with a whole host of new stories to share with my students.
Kornberg has a passion for research that is contagious. While it doesn't make me want to quit my teaching job, it does remind me why I went into biochemistry in the first place and makes me want to pass that along. And it makes me grateful that I do have some opportunties to continue doing some research of my own, limited as time and resources may be. He gives strong arguments for basic research and how they often lead to very practical applications.
One of my favorite passages from the book...
... Biologists, chemists, and physicists can present the human body to medical students as an uninterrupted ascent from atoms to man: from the tens of atoms that make a small molecule, to the tousands of molecules that make a polymer (such as a protein or a nucleic acid), to the millions of such polymers that make a cell, to the billions of cells that make a tissue, and the trillions of specialized cells that create a body. In a wider, panoramic view, the human body and its behavior becomes a tiny decoration in the tapestry of life interwoven with the incredible variety of plasmids, viruses, bacteria, plants, and animals in a 4-billion-year evolutionary development.
The coalescence of the biological and medical sciences, as illustrated by these several examples, is based largely on their expression in a common language, chemistry. Understanding all of life, human behavior included, as chemistry links the biological sciences with all the physical sciences- the atmospheric, earth, and engineering sciences. Chemical language, rech and fascinating, paints images of great aesthetic beauty with beguilingly deeper mysteries.
I feel that reading about Kornberg's experiences in science will change the way I approach teaching many different aspects of all of my classes. I'd love to include it as required reading for my biochem class, but as I think about it, I realize that I wouldn't have gotten nearly as much out of it as an undergraduate. So I don't think I'll be using the entire book, although I may assign certain chapters, and recommend it in entirety for a few students that are grad school and research bound. And I'll be keeping a copy on my desk for reference.
























