3. Swallowing problems or hoarseness
Source: MSN Health
Quick summary
If your parent has received a diagnosis of cancer, he'll soon be plunging into the complex world of cancer treatment. Typically, your parent's doctor will refer him to an oncologist, who plans a course of treatment. This may be a single process, such as chemotherapy, or more likely it will be a combination of different treatment types, such as surgery followed immediately by radiation, followed later by a course of chemo. Within each of these treatment categories, there are myriad distinctions to understand and decisions to make, which can leave you and your parent feeling overwhelmed.
To help you and your parent sort through the maze of cancer treatments, here's a guide to the main types and how they work.
Neoadjuvant therapy and adjuvant therapy for cancer treatment
Sometimes oncologists prescribe chemotherapy, radiation, or other drugs, such as hormones, to shrink a tumor priorto surgery. This is known as neoadjuvant therapy. Adjuvant therapy is the term for chemotherapy or radiation given after surgery.
Surgery for cancer treatment
If the doctor identifies a tumor that's safe for removal, surgery is going to be an important part of your parent's treatment. The oldest form of cancer treatment, surgery is still considered the best way to remove cancerous tissue, particularly when it's localized in one area of the body. The goal in surgery is to remove the entire tumor, including the cancerous cells spreading around the edge, or "margin," of the tumor.
Your parent's doctor may discuss one or a number of different types of surgery:
Biopsies are the most common type of diagnostic surgery. Using a needle, the doctor draws a tissue sample from a tumor. Biopsies can also be done by cutting through the tissue with a knife or laser. An excisional biopsy is one that cuts out the entire tumor, while an incisional biopsy removes a small part of a larger tumor. Unlike regular surgery, biopsies are often outpatient procedures performed using local anesthesia.
Endoscopies often done in tandem with biopsies, use a flexible tube and scope to pass through the throat or colon in order to examine a potentially cancerous area without cutting through the skin. Endoscopies are also usually done on an outpatient basis.
Laparoscopies are similar to endoscopies, but they do require a small incision -- usually in the abdomen -- through which the doctor inserts the scope.
Chemotherapy for cancer treatment
One of the most effective ways to kill off cancer cells is with toxic chemicals called chemotherapy agents, which are drugs developed to target fast-growing cells. There are many different chemotherapy drugs, and some attack a variety of types of cancer while others focus on particular cancers, such as breast cancer or lung cancer.
Chemotherapy drugs work by targeting all fast-growing cells, so they also affect rapidly dividing cells in other parts of the body, such as the hair, the mouth, and the digestive system, which is what leads to common side effects such as dry mouth and hair loss. Unlike radiation and surgery, which are site-specific, or "local," chemotherapy is considered a "systemic" treatment, since the medications travel throughout the body.
• Chemotherapy drugs. Some chemotherapy drugs, called "nonspecific," are capable of killing cancer cells during any phase of growth; others, called "specific," can kill cancer cells only during a specific phase and not while the cell is resting. Doctors often create a chemotherapy regimen by combining specific and nonspecific chemo agents for maximum effect.
When your parent's doctor chooses a drug, she also makes decisions about dosage level, frequency of dosage, and length of treatment. These decisions can affect how easy or difficult it is for your parent to tolerate his chemo regimen. The more you can find out about exactly which drugs will be used, in what dosages, and for how long, the better prepared you and your parent can be to cope with the side effects to come. Some chemotherapy drugs are given through an IV while others can be taken orally or by injection.
• Chemotherapy schedules. Nowadays, chemotherapy is most often performed on an outpatient basis, though if your parent has to be hospitalized for surgery, the doctor may start chemo while he's still in the hospital.
Chemotherapy is usually given in cycles, with periods of treatment followed by periods of rest to let your parent's body recover. Your parent might receive three weeks of chemo followed by one week of rest, or one week of chemo followed by three weeks of rest. Either way, a full four weeks makes up one cycle. Sometimes your parent has to meet certain health criteria in order to go through the next round of chemotherapy. For example, the doctor may monitor your parent's blood cell counts, and if his white or red blood cell count drops too low, the doctor may have to postpone the next round of chemo until the count rises again.
Radiation therapy for cancer treatment
Radiation can be performed after a tumor is surgically removed to catch stray cancer cells, before surgery to shrink a tumor, or as a stand-alone therapy.
There are two general kinds of radiation therapy: internal and external. Doctors usually recommend internal radiation, also called brachytherapy, when they want to target the cancer with a high dose of radiation delivered internally to a small area, such as tumors located in the breast, prostate, head, or neck. The radiation is implanted or injected in wires, "seeds," or capsules, then left in place for a period of time, either until they're removed or until they decay and become inactive. Brachytherapy is usually performed as an outpatient procedure, though sometimes doctors choose to implant a radioactive "source" at the end of surgery.
When the radiation is beamed into the body from an outside source, most often from an X-ray machine or linear accelerator, it's called external radiation. External radiation is usually given in the form of a sequence of treatments, typically five days a week for six to eight weeks. (On weekends, your parent gets a break so his body can recover.)
Radiation therapy is a rapidly improving technology, and there are many different types available.
Hormone therapy for cancer treatment
Used most often to treat breast and prostate cancers, hormone therapy uses the body's own natural hormones to treat cancers that are affected by the hormones produced by the endocrine system. Because hormones fuel the growth of some types of cancer, cutting off or blocking the action of those hormones can stop the cancer from growing. Estrogen blockers, for example, can be very effective in treating some types of breast cancer, while blocking testosterone can be effective in preventing the growth of prostate cancer cells.
By Melanie Haiken, Caring.com senior editor
Annual checkups and tests such as colonoscopies and PSA assays are important, but it's not a good idea to rely on tests alone to protect you from cancer. It's just as important to listen to your body and notice anything that's different, odd, or unexplainable. (You should also listen to those close to you, such as a wife or partner, because others sometimes notice things we're unaware of—or don't want to admit.) You don't want to join the ranks of cancer patients who realize too late that symptoms they'd noticed for a long time could have sounded the alarm earlier, when cancer was easier to cure.
Here, some signs of cancer that are commonly overlooked:
1. Upset stomach or stomachache
One of the first signs colon cancer patients remember experiencing when they look back is unexplained stomach aches. Those with pancreatic cancer describe a dull ache that feels like it's pressing inward. Many liver cancer patients say they went in complaining of stomach cramps and upset stomachs so frequently that their doctors thought they had ulcers. Liver cancer patients and those with leukemia can experience abdominal pain resulting from an enlarged spleen, which may feel like an ache on the lower left side.
If you have a stomachache that you can't attribute to a digestive problem or that doesn't go away, ask your doctor to order an ultrasound. Finding a liver or pancreatic tumor early can make all the difference in treatment.
2. Chronic "acid stomach" or feeling full after a small meal
The most common early sign of stomach cancer is pain in the upper or middle abdomen that feels like gas or heartburn. It may be aggravated by eating, so that you feel full when you haven't actually eaten much. What's particularly confusing is that the pain can be relieved by antacids, confirming your conclusion that it was caused by acid in the stomach, when it's more than that. An unexplained pain or ache in lower right side can be the first sign of liver cancer, known as one of the "silent killers." Feeling full after a small meal is a common sign of liver cancer as well.
If you have frequent bouts of acid stomach, an unexplained abdominal ache, or a full feeling after meals even when you're eating less than normal, call your doctor.
3. Unexplained weight loss
If you notice the pounds coming off and you haven't made changes to your diet or exercise regime, it's important to find out why. Unexplained weight loss can be an early sign of colon and other digestive cancers; it can also be a sign of cancer that's spread to the liver, affecting your appetite and the ability of your body to rid itself of waste.
4. Jaundice
Pancreatic cancer, another one of the "silent killers," is often discovered when someone notices jaundice and asks the doctor to do a battery of tests. Jaundice is most commonly thought of as a yellowing of the skin or whites of the eyes, but darker-than-normal urine that's not the result of dehydration is also a sign. Clay-colored stools are another little-known sign of jaundice. Oddly, jaundice can also cause itching, because the bile salts in the bloodstream cause the skin to itch. Some people with pancreatic cancer say they noticed the itching before they noticed the jaundice itself.
5. Wheezing or shortness of breath
One of the first signs lung cancer patients remember noticing when they look back is the inability to catch their breath. "I couldn't even walk to my car without wheezing; I thought I had asthma, but how come I didn't have it before?" is how one man described it. Shortness of breath, chest pain, or spitting blood are also signs of testicular cancer that's spread to the lungs.
6. Chronic cough or chest pain
Several types of cancer, including leukemia and lung tumors, can cause symptoms that mimic a bad cough or bronchitis. One way to tell the difference: The problems persist, or go away and come back again in a repeating cycle. Some lung cancer patients report chest pain that extends up into the shoulder or down the arm.
7. Frequent fevers or infections
These can be signs of leukemia, a cancer of the blood cells that starts in the bone marrow. Leukemia causes the marrow to produce abnormal white blood cells, which crowd out healthy white cells, sapping the body's infection-fighting capabilities. Doctors sometimes catch leukemia in older adults only after the patient has been in a number of times complaining of fever, achiness, and flu-like symptoms over an extended period of time.
8. Difficulty swallowing
Most commonly associated with esophageal or throat cancer, having trouble swallowing is sometimes one of the first signs of lung cancer, too. Men diagnosed with esophageal cancer look back and remember a feeling of pressure and soreness when swallowing that didn't go away the way a cold or flu would have. Consult your doctor also if you have a frequent feeling of needing to clear your throat or that food is stuck in your chest; either of these can signal a narrowing of the esophagus that could mean the presence of a tumor.
9. Chronic heartburn
If you just ate half a pizza, heartburn is expected. But if you have frequent episodes of heartburn or a constant low-level feeling of pain in the chest after eating, call your doctor and ask to be screened for esophageal cancer. Gastroesophageal reflux disease (GERD)—a condition in which stomach acid rises into the esophagus, causing heartburn and an acidic taste in the throat—can trigger a condition called Barrett's esophagus, which can be a precursor of esophageal cancer.
10. Swelling of facial features
Some patients with lung cancer report that they noticed puffiness, swelling, or redness in the face. The explanation for this is that small cell lung tumors commonly block blood vessels in the chest, preventing blood from flowing freely from the head and face.
11. Swollen lymph nodes or lumps on the neck, underarm, or groin
Enlarged lymph nodes indicate changes in the lymphatic system, which can be a sign of cancer. For example, a lump or an enlarged lymph node in the neck or underarm is sometimes a sign of thyroid, head, or throat cancer. A painless lump on the neck, underarm, or groin can be an early sign of leukemia.
12. Excessive bruising or bleeding that doesn't stop
This symptom usually suggests something abnormal happening with the platelets and red blood cells, which can be a sign of leukemia. One man with leukemia noticed that his gums bled when he brushed his teeth; another described bruising in strange places, such as on his fingers and hands. The explanation: Over time, leukemia cells crowd out red blood cells and platelets, impairing the blood's ability to carry oxygen and clot.
13. Weakness and fatigue
"I had to stop halfway across the yard and sit down when I was mowing the lawn," said one man when describing the fatigue that led to his discovery of pancreatic cancer. Generalized fatigue and weakness is a symptom of so many different kinds of cancer (and other ills) that you'll need to look at it in combination with other symptoms. But any time you feel exhausted without explanation and it doesn't respond to getting more sleep, talk to your doctor.
14. Rectal bleeding or blood in the stool
"I thought it was hemorrhoids" is one of the most common statements doctors hear when diagnosing colorectal cancer. Blood in the toilet alone is reason to call your doctor and schedule a colonoscopy. Another sign of blood in the stool many people miss is stools that are darker in color.
15. Bowel problems
Constipation, diarrhea, and changes in stools can all be signs of cancer. As with many other cancer symptoms, the way to tell if this is cause for concern is if it goes on for more than a few days without a clear cause, such as flu or food poisoning. People diagnosed with colon cancer say they noticed more frequent stools, as well as a feeling that their bowels weren't emptying completely. One of the early signs of pancreatic cancer is fatty stools, which can be recognized as frequent, large stools that are paler than normal and smelly. This is a sign that your body's not absorbing your food normally, and it should be brought to your doctor's attention.
16. Difficulty urinating or changes in flow
Hands-down, the most common early sign of prostate cancer is a feeling of not being able to start peeing once you're set to go. Many men also report having a hard time stopping the flow of urine, a flow that starts and stops, or a stream that's weaker than normal. Any of these symptoms is reason to call your doctor for an exam and a screening test for prostate-specific antigen (PSA).
17. Pain or burning during urination
This symptom can also indicate a urinary tract infection or sexually transmitted disease, of course, but in any case it warrants an immediate trip to the doctor. This symptom is often combined with the feeling that you need to go more often, particularly at night. These same symptoms can also indicate inflammation or infection in the prostate or benign prostatic hyperplasia, the name for what happens when the prostate grows bigger and blocks the flow of urine. However, you need to get checked out to tell the difference.
18. Blood in urine or semen
Men are often warned about blood in the urine, but they may not realize that blood in semen is also a danger sign for prostate cancer. Blood in the urine or semen isn't always visible as blood; urine may just be a pink, dark red, or smoky brown color, while blood in the semen may just look like a pinkish streak.
19. Erection problems
As prostate cancer progresses, another very common sign is difficulty getting or sustaining an erection. This can be a difficult subject to talk about, but it's important to bring it to your doctor's attention. It could be a sign of sexual dysfunction with another cause, of course, but it's a reason to have an exam and a PSA test.
20. Pain, aching, or heaviness in the groin, hips, thighs, or abdomen
One sign of prostate cancer is frequent pain in the hips, upper thighs, or the lowest part of the back. Men with testicular cancer report noticing a heavy, aching feeling low in the belly or abdomen, or in the scrotum or testicles themselves. They sometimes describe it as a feeling of downward pulling or as a generalized ache throughout the groin area. Prostate cancer that has spread to the lymph nodes often makes itself known as discomfort in the pelvis or swelling in the legs.
21. Testicular swelling or lump
The lumps that indicate testicular cancer are nearly always painless. It's also common for a testicle to be enlarged or swollen, but lacking any specific lump that you can see or feel. Some men report feeling discomfort from the enlargement, but not an outright pain.
22. Unexplained back pain
Back pain can mean all sorts of things, of course—most often pulled muscles or disc problems. But unexplained, persistent back pain can be an early sign of cancer as well, so get it checked out. Pain in the lower back and hips can be a sign of prostate cancer, while pain in the upper back can signal lung cancer. A pain in the upper abdomen and back is one of the few early signs of pancreatic cancer.
23. Scaly or painful nipple or chest, nipple discharge
Men do get breast cancer; they also get a condition called gynecomastia, which is a benign lump in the breast area. Breast cancer is usually detected as a lump, but if it's spreading inward it can also cause chest pain. Other signs of breast cancer include patches of red, scaly, or dimpled skin or changes to the nipple such as turning inward or leaking fluid. Bring any lump, swelling, or skin or nipple problem, or any chest pain, to your doctor's attention.
24. A sore or skin lump that doesn't heal, becomes crusty, or bleeds easily
Most of us know to watch moles for changes that might indicate skin cancer. But other signs, such as small waxy lumps or dry scaly patches, are easier to miss. Familiarize yourself with the different types of skin cancer—melanoma, basal cell carcinoma, and squamous cell carcinoma—and be vigilant about checking skin all over the body for odd-looking growths or spots.
25. Changes in nails
Unexplained changes to the fingernails can be a sign of several types of cancer. A brown or black streak or dot under the nail can indicate skin cancer, while newly discovered "clubbing," which means enlargement of the ends of the fingers, with nails that curve down over the tips, can be a sign of lung cancer. Pale or white nails can be an indication that your liver is not functioning properly, sometimes a sign of liver cancer.
Would you change your lifestyle if you could slash your risk of getting cancer by a third or even half? That's the challenge posed by a huge new report just released in late February by The American Institute for Cancer Research that pulls together and analyzes the most comprehensive data on cancer prevention yet.
Okay, I admit it, you're not going to like some of this advice, and neither are your family members. I know I don't. Give up salami, one of my favorite lunch options? Yikes. And alcohol? As native Californians who grew up going wine tasting in the Napa Valley whenever possible, my siblings would be really sad if family dinners were no longer accompanied by a bottle of good zinfandel or pinot. And what's a burrito without a cold beer and lime to go with it?
But this evidence is so compelling that I think all of us in Cancer World are going to have to look twice at some of our lifestyle choices and may feel newly motivated to make changes, or nag at our loved ones to do so. Imagine, by following these guidelines, we could prevent:
This report is a big deal because the experts who compiled it looked at every major study and based their recommendations on hard evidence of what really works to reduce cancer risk. "This is the practical application of five years of work sorting through what the science really says," said panel member Steve Zeisel, M.D., of the University of North Carolina at Chapel Hill.
One last thing; this report did not even address smoking, because experts consider that such a no-brainer at this point. Smokers increase their chances of getting almost all kinds of cancer every time they light up. So the only recommendation is, don't.
"Even relatively low levels of drinking -- on the order of one alcoholic drink per day -- increase a woman's risk of developing cancer," said lead researcher Naomi Allen, from the cancer epidemiology unit at the University of Oxford in the United Kingdom. "Because a high proportion of women drink low amounts of alcohol regularly and because most of the increased risk is for breast cancer, the risk among women associated with drinking alcohol is of particular importance."
In fact, the study found that moderate drinking accounts for 13 percent of breast, liver, rectum and upper respiratory/digestive tract cancers among women.
The association between moderate alcohol intake and breast cancer in women is well-known, the researchers point out. What's new here, they say, is the finding that even low levels of drinking can raise a woman's risk of developing cancer of the liver and rectum. For women who smoke, cancers of the mouth and throat were also linked to high alcohol consumption.
The report is published in the Feb. 24 online edition of the Journal of the National Cancer Institute.
For the study, Allen's team collected data on more than 1.2 million middle-age British women participating in the Million Women Study. The researchers used the National Health Service Central Registries to identify cancer cases among these women.
Most women in the study had about a drink a day, and a smaller percentage had three or more drinks a day, the researchers found. Over more than seven years of follow-up, 68,775 women developed cancer.
"These findings are robust, and alcohol consumption was assessed several times before women were diagnosed with cancer, making these estimates reliable," Allen said.
Overall, the risk of cancer increased as alcohol consumption increased. The type of alcohol consumed appeared to make no difference.
Women who drank and also smoked faced increased risk of cancers of the oral cavity and pharynx, esophagus, and larynx (voice box), the researchers found.
The study suggests "that in developed countries, where women typically consume low-moderate amounts of alcohol, we estimate that for every additional drink regularly consumed each day, there would be about 15 extra cases of cancers of the breast, liver, rectum and mouth and throat diagnosed for every 1,000 women up to the age of 75," Allen said. "Most of this excess risk is due to breast cancer."
Susan M. Gapstur, vice president of epidemiology at the American Cancer Society, said the findings confirm and expand on those from previous studies in men and in smaller cohorts of women.
But several questions remain unanswered, she said. "For example, researchers remain concerned about the pattern of consumption," Gapstur said. "It is unclear, for example, whether someone who drinks several glasses of wine on one day during the week has the same risk as someone who drinks one glass of wine per day with a meal. In addition, the effects of quitting or reducing drinking on cancer risk are also unclear."
The American Cancer Society currently recommends limiting intake to one drink a day for women and two drinks a day for men, Gapstur said.
On the other hand, numerous studies have suggested that alcohol, especially red wine, might help deter heart disease -- complicating decisions around drinking and health.
"If you do not drink, there is no reason to start drinking," Gapstur reasoned. "However, in light of the findings from the Million Women Study, women who are concerned about their cancer risk versus their risk of cardiovascular disease might want to discuss the potential risks and benefits of even low alcohol intake with their health-care providers."
In an accompanying journal editorial, Dr. Michael Lauer, director of the Division of Prevention and Population Sciences at the U.S. National Heart, Lung and Blood Institute, said he believes the risk for cancer might outweigh any perceived benefit in terms of heart disease.
"People who are not drinkers should not start drinking to prevent heart disease, and even people who are drinking should discuss this with their physicians," he said. "And as part of that conversation, they should consider other conditions than heart disease. We cannot just focus on heart disease."
The American Institute for Cancer Research's (AICR) latest recommendation—not to rely on supplements for cancer prevention—took many people by surprise. Why, many wonder, does a report that links vegetables, fruits and whole grains with lower cancer risk not attribute that same protective influence to the supplements that contain the very nutrients and antioxidants found in the whole foods? In addition, they ask, what harm can really be done by buying some additional "nutritional insurance" from nutritional supplements?
For starters, taking a dietary supplement does not provide the same benefits as healthful eating. The disease-fighting properties ascribed to a diet that features antioxidant-rich plant foods cannot be packaged into a pill or powder. Experts believe that it is the interaction of the vitamins, minerals and phytochemicals in these foods—a process called synergy—that provides cancer protection. Adding just a handful of these compounds to a supplement will not garner the same effect as eating a varied plant-based diet.
Although supplements can play an important role in filling specific nutritional gaps, they don't provide the protection that some people may expect—especially when it comes to disease prevention. If these supplements worked, we would see lower incidence of cancer among those who take them, but we don't. In fact, a report issued by the National Institutes of Health (NIH) on multivitamin/mineral supplements and chronic disease prevention recently concluded: "The present evidence is insufficient to recommend either for or against the use [of multivitamins/minerals] by the American public."
Those still convinced that they should pop a pill "just in case" should note that a study published last year in the Journal of the National Cancer Institute advises caution. In the study, although no effect (positive or negative) was seen between multivitamin intake and risk of localized prostate cancer, researchers saw a 32 percent increase in risk of advanced prostate cancer among men who used more than seven multivitamins per week. This increase was also evident among men who took a multivitamin along with an individual nutrient supplement such as selenium, beta-carotene or zinc.
The notion that supplements may cause more harm than good is not new. A recently published analysis of 68 large trials involving more than 232,000 adults given antioxidant supplements showed either no benefit or even increased mortality with some antioxidants. Similarly, AICR's landmark report, Food, Nutrition, Physical Activity, and Cancer Prevention: A Global Perspective, concluded that there is strong and convincing evidence that beta-carotene supplements cause lung cancer in smokers.
The AICR report also urges caution even among those supplements that have shown a positive effect in reducing cancer risk. Selenium supplements, for example, can probably lower risk of prostate cancer, according to AICR experts, but the mineral can be toxic at high doses. In addition, although the AICR report concludes that calcium supplements can probably protect against colorectal cancer, they also warn that calcium intake beyond amounts recommended for healthy bones (1,200-1,500 milligrams per day) probably increases risk of prostate cancer. A recent study linking calcium supplements with risk of heart attack in older women also raises important questions.
Is the AICR report saying, "Don't use supplements?" No, the report is saying not to turn to supplements for cancer protection at this time. Certain people may benefit from supplements in ways unrelated to cancer risk, including:
People at risk for osteoporosis may require calcium and vitamin D supplements, too.
Major advances in the treatment and detection of breast cancer in the last two decades have saved the lives of millions of women. Since 1990, mortality rates have decreased dramatically—by 3.3 percent a year in women under 50 and by 2 percent a year in older women. Experts say that breakthroughs made in the past few years, however, may have an even greater impact in the fight against breast cancer. Here are five reasons researchers are excited—and hopeful.
Clearer screenings
Magnetic resonance imaging (MRI), best known for its use in brain scans, is now revolutionizing breast-cancer screening and diagnosis in high-risk women. Unlike mammography, which identifies lumps and calcifications, MRI uses contrast to look at blood vessels, which can't be obscured by breast implants or naturally dense tissue. Since the blood supply to malignant cells differs from healthy cells, the cancers appear as bright spots on the digital image.
"The downside of MRI is that it picks up so much, including benign structures, that there are more recommendations for biopsies," says Dr. Christy Russell, co-director of the Breast Cancer Center at the University of Southern California. For an average-risk woman, the procedure is not worth it, she adds. For women with a BRCA1 or 2 gene mutation, however, an MRI could be lifesaving. In fact, the American Cancer Society recently updated its guidelines to recommend that all high-risk women age 40 and older be screened annually with both mammography and MRI.
Tougher drugs
Experts are optimistic about a new class of drugs known as aromatase inhibitors (AIs), "one of the most exciting things to happen in years," says Dr. Larry Norton, deputy physician in chief of Breast Cancer Programs at Memorial Sloan-Kettering Cancer Center in New York City. Many breast cancers are fed by estrogen, which tells the malignant cells to grow. In postmenopausal women, an enzyme in the breast itself, called aromatase, converts other hormones into estrogen. AIs have been used successfully to block that conversion.
In a recent National Cancer Institute of Canada study, women who were switched to an AI after two years of taking tamoxifen—a medication that's been used successfully to treat breast cancer since 1977—had 32 percent less risk of a recurrence, a new breast cancer, or death than those who stayed on the original drug.
Better biopsies
First performed on breast-cancer patients in the mid-1990s, sentinel lymph node biopsy—a procedure that involves removing one to three lymph nodes to check for cancer cells—has now become the standard of care. The technique saves patients a great deal of risk, pain, healing time, and scarring. "It used to be that we would go in and remove many of the lymph nodes from a patient's armpit to figure out if any were involved," explains Dr. Russell. "Now, if surgeons remove just one node or two nodes that are cancer-free, it is unlikely that others are involved. If it's positive, then the surgeon goes back in and removes the rest." The more nodes that test positive for cancer cells, the greater the risk of cancer recurrence.
Targeting stem cells
When you hear the term "stem cells," you likely think of the controversial embryonic type, but adults have stem cells, too. Unfortunately, so do cancerous tumors. Experts believe that, just like in healthy organs and tissue, stem cells are what spur and direct a cancer's growth. "A lot of our traditional therapies [for example, chemo] kill the surrounding cells very well, but not the stem cells," explains Dr. Max Wicha, director of the University of Michigan Comprehensive Cancer Center in Ann Arbor. "We have to figure out ways of knocking them out."
In clinical trials at the Baylor College of Medicine, at least one medication has been shown to successfully kill stem cells. Dr. Wicha's team, along with researchers at Baylor and Harvard, currently is investigating another drug, originally developed for Alzheimer's disease.
Gene-based treatments
Genetics in breast-cancer research is no longer limited to looking at the patient's genes. Now doctors and researchers are examining the genetic information of cancer cells themselves to help determine the best treatment options. One such test already is widely used with women whose cancer has not spread to lymph nodes. This type of genomic profiling also has led to the creation of super-effective drugs used to target a specific aggressive type of tumor that makes up about 15 percent to 30 percent of all breast-cancer cases.
But, experts say, what's even more important than these drugs themselves is the evidence that targeted therapies can work. Zeroing in on specific genes and molecules, Dr. Wicha says, is critical to the future of breast cancer treatment. "It's pointing us in the right direction."
As many as 15 million new cases of cancer are thought to be discovered by 2020. With many types of medication and alternative therapies on the market, people are forgetting the most important medicine of all - a healthy diet. A particular group of foods that contain phytochemicals, antioxidants and omega 3 may help reduce the risk of cancer.
These are an antioxidant that is not only helpful for reducing the risk of cancer but is beneficial for cataracts and glaucoma due to its ability to block certain fats in the body. It can also regulate high blood pressure.
Including cabbage, and cauliflower have phytochemicals which combat some types of cancer. They are also low in calories and high in fibre.
A powerful antioxidant that is also high in beta carotene. It can help reduce the risk of cancer with its secret ingredient falcarinol.
These can kill bacteria and assist in weight loss programs. They contain an important ingredient called benzaldehyde which studies have shown can decrease the size of tumors.
Boosts the immune system and can reduce development of some tumors. Eaten in its raw state it is said to reduce the risk of many types of stomach cancers.
The red grapes contain natural antioxidants that may slow down the development of cancer cells and tumor growth. If eaten as part of the 5 a day regime, a portion of grapes can be effective.
Shitake mushrooms help boost the immune system as it acts as an antibacterial agent. It is good for influenza, diabetes, headaches and reducing the risk of cancer. Maitake and Reishi are also known for their anti-cancer abilities.
Contains polyphenols which are powerful antioxidants. Red wine should be drunk in moderation although alcohol free red wine and grape juices are found to be just as rich in polyphenols as the key ingredient lies in the grape skin.
Polyphenols are found in green tea which can slow down the development of cancer cells. Black tea can also provide some benefit although herbal teas have yet to be proven effective.
These contain lycopene which can decrease the amount of free radicals from entering our body. The level of lycopene is found to be higher when the tomatoes are concentrated such as in a puree or in ketchup. Studies have also shown that lycopene is absorbed into the body at a greater rate if it is accompanied by oil.