mTOR - Wikipedia
The mTOR pathway is a central regulator of mammalian metabolism and physiology, with important roles in the function of tissues including liver, muscle, white and brown adipose tissue, [33] and the brain, and is dysregulated in human diseases, such as diabetes, obesity, depression, and certain cancers.
mTOR Signaling in Growth, Metabolism, and Disease - PMC
In this review, we provide an overview of our current understanding of the mTOR pathway and its role in growth, metabolism, and disease.
mTOR signaling at a glance - PMC - PubMed Central (PMC)
The mammalian target of rapamycin (mTOR) signaling pathway integrates both intracellular and extracellular signals and serves as a central regulator of cell metabolism, growth, proliferation and survival.
mTOR Pathway - Cell Signaling Technology
Pathway Description: The mechanistic target of rapamycin (mTOR) is an atypical serine/threonine kinase that is present in two distinct complexes. The first, mTOR complex 1 (mTORC1), is composed of mTOR, Raptor, GβL, and DEPTOR and is inhibited by rapamycin.
What is the mTOR Signaling Pathway? - News-Medical.net
Mar 9, 2020 · There are 4 main functions of the mTOR signaling pathway: cell growth and proliferation, angiogenesis, bioenergetics through nutrient availability and boosting of metabolism, and cell survival...
Multifaceted role of mTOR (mammalian target of rapamycin) …
Oct 2, 2023 · The emerging pieces of evidence have revealed that the constitutive activation of the mTOR pathway due to mutations/amplification/deletion in either mTOR and its complexes (mTORC1 and mTORC2)...
mTOR Signaling in Growth, Metabolism, and Disease - Cell Press
Extensive research over the past two decades has established a central role for mTOR in regulating many fundamental cell processes, from protein synthesis to autophagy, and deregulated mTOR signaling is implicated in the progression of cancer and diabetes, as well as the aging process.
mTOR at the nexus of nutrition, growth, ageing and disease
Jan 14, 2020 · The mTOR pathway integrates diverse environmental cues to control biomass accumulation and metabolism by modulating key cellular processes, including protein synthesis and autophagy.
mTOR: from growth signal integration to cancer, diabetes and …
Dec 15, 2010 · In all eukaryotes, the target of rapamycin (TOR) signalling pathway couples energy and nutrient abundance to the execution of cell growth and division, owing to the ability of TOR protein...
mTOR Signaling Pathway - Definition, Types, Mechanism, and FAQs
Jan 12, 2024 · The mTOR signaling pathway, which is frequently activated in tumors, is crucial for tumor metabolism because it not only controls protein synthesis and gene transcription to control immune cell differentiation and cell proliferation.