Toll like receptor 9 (TLR9) has been considered as a crucial intracellular pattern recognition receptor in the immune system, which can directly or indirectly mediate innate and adaptive immune responses by recognizing CpG DNA in endosomes to initiate its downstream signaling.

Jul 28, 2022 · Toll-like receptor 9 (TLR9) agonists have been extensively investigated as therapeutics in monotherapy or combination therapies for the treatment of cancer, infectious diseases and...

Sep 1, 2023 · Toll like receptor 9 (TLR9) has been considered as a crucial intracellular pattern recognition receptor in the immune system, which can directly or indirectly mediate innate and adaptive immune responses by recognizing CpG DNA in endosomes to …

Jan 2, 2024 · Here, we report that palmitoyl-protein thioesterase 1 (PPT1) regulates systemic autoimmunity by removing S-palmitoylation from TLR9 in lysosomes. PPT1 promotes the secretion of IFNα by...

TLR9 is a receptor that recognizes specific DNA motifs found in both bacterial and viral DNA, and has the potential to be targeted for adjuvants. Recent studies suggest that TLR9 may play a role in the production of autoantibodies, which are antibodies that target self-components.

Dec 25, 2024 · TLR9 (Toll Like Receptor 9) is a Protein Coding gene. Diseases associated with TLR9 include Cervicitis and Measles. Among its related pathways are Toll Like Receptor 7/8 (TLR7/8) Cascade and Insulin receptor signalling cascade. Gene Ontology (GO) annotations related to this gene include transmembrane signaling receptor activity and siRNA binding.

In this review article, we describe the distribution, structure and signaling of TLR9; discuss the results of preclinical studies of TLR9 agonists; and review ongoing clinical trials of TLR9 agonists singly and in combination in patients with advanced solid tumors.

Feb 8, 2025 · Title: Loss of Toll-like receptor 9 protects from hepatocellular carcinoma in murine models of chronic liver disease. Investigation of TLR2 (-196 to -174del) and TLR9 (T-1486C) Gene Polymorphisms Association with Inflammatory Bowel Diseases.

Oct 9, 2020 · In this review article, we describe the distribution, structure and signaling of TLR9; discuss the results of preclinical studies of TLR9 agonists; and review ongoing clinical trials of TLR9 agonists singly and in combination in patients with advanced solid tumors.

Feb 8, 2025 · Toll-like receptor 9 expressed in proximal intestinal enteroendocrine cells detects bacteria resulting in secretion of cholecystokinin. TLR9 expression is associated with PD-L1 expression and indicates a poor prognosis in patients with peripheral T-cell lymphomas.