Nov 29, 2023 · Colchicine is a substrate for P-glycoprotein (P-gp) [5], which is present in the gut wall, kidneys, liver, and blood–brain barrier, with its primary function being to facilitate the …

May 16, 2024 · In people with kidney or liver disease, colchicine may cause a potentially fatal reaction with other medications that inhibit P-glycoprotein or CYP3A4 (such as ketoconazole, …

Nov 2, 2022 · Colchicine use is associated with a lower risk of adverse kidney outcomes in CKD patients with hyperuricaemia, or chronic gout.

f 0.6 mg is recommended, and should not be repeated more than once every two weeks. Colchicine is contraindicated in patients with renal impairment who are also taking P-gp …

Colchicine can be used in low doses as prophylaxis, with caution and appropriate monitoring. NSAIDs should be avoided, and glucocorticoids may not be effective for this purpose. Whether …

We report a case of a 76-year-old female with stage 4 chronic kidney disease (CKD) who experienced multiple adverse events following the initiation of colchicine for a gout flare. …

Colchicine is generally a safe medicine, if you follow your doctor's instructions. However, if you are taking a high dose for a long time, there is a small risk of getting kidney or liver problems. …

Research indicates that colchicine can indeed affect kidney function, especially in individuals with pre-existing renal conditions. The primary concerns revolve around nephrotoxicity—the …

In patients with renal impairment, colchicine was not associated with an increased risk of dialysis, time until dialysis, or the incidence of liver function test derangement. We found no data for …

Jul 9, 2015 · Colchicine toxicity has been linked to renal function and it has generally been advised to adjust colchicine dosing in patients with renal insufficiency.