dosage adjustment criteria) Patients with end-stage renal disease (ESRD) on dialysis: ... reduce the dose of ELIQUIS by 50% when ELIQUIS is coadministered with drugs that are combined P-gp and strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole, or ritonavir). In patients already taking 2.5 mg twice daily, avoid coadministration of ELIQUIS
Clarification for Apixaban Dosing in Patients with Impaired ... - AAFP
Apr 15, 2018 · In Table 1, we recommended modified dosing of apixaban (2.5 mg twice daily) if at least one of the following criteria is met: serum creatinine 1.5 mg per dL (133 μmol per L) or greater, age 80...
Apixaban for Extended Treatment of Venous Thromboembolism
Feb 21, 2013 · At a dose of 5 mg twice daily, apixaban has been shown to be effective for the prevention of stroke in patients with atrial fibrillation, and at a dose of 2.5 mg twice daily, the lowest...
Critical Analysis of Apixaban Dose Adjustment Criteria - PMC
For NVAF, apixaban is dosed at 5 mg orally twice daily and is reduced to 2.5 mg twice daily in patients who meet 2 of the following criteria: age > 80 years, body weight <60 kg, and serum creatinine (SCr) > 1.5 mg/dL. 1 Placement of these criteria within the Cockcroft-Gault formula would provide an estimated glomerular filtration rate (eGFR) of ...
Optimal Prescription of the Lower Dose of Apixaban
According to the ARISTOTLE and AVERROES trial protocols, the majority of patients received apixaban at the standard dose of 5 mg twice daily, and only those who met at least 2 of 3 criteria for dose reduction (age ≥80 years, body weight ≤60 kg, and creatinine level ≥1.5 mg/dl or 133 μmol/l) received the lower dose of 2.5 mg twice daily.
Validity of different dose reduction criteria for apixaban
Reduced-dose apixaban is recommended in patients fulfilling 2 of 3 criteria: age ≥80 years, body weight ≤60 kg, and serum creatinine ≥1.5 mg/dL. However, patient weight is often not available in electronic health data.
Have you reduced Eliquis dosage - Mayo Clinic Connect
Nov 6, 2024 · I’ve been on Eliquis since 2019 for second incidence of bi-lateral lung clots. I’ve asked pcp to reduce to 2.5 mg twice per day from 5.0 mg twice per day. Just wondering if anyone has reduced their dosage and pros/cons of doing so.
Apixaban Dosage Guide + Max Dose, Adjustments - Drugs.com
Aug 15, 2024 · Reduce dose to 2.5 mg orally 2 times a day if patient is 80 years or older OR body weight is 60 kg or less. Deep vein thrombosis prophylaxis after hip or knee replacement: No adjustment required. Deep vein thrombosis (DVT) and pulmonary embolism (PE) treatment: No adjustment required.
Dosing & Administration for DVT/PE | Rx ELIQUIS® (apixaban) …
Reduce dose by 50%: For patients receiving ELIQUIS doses of 5 mg or 10 mg twice daily, when ELIQUIS is coadministered with drugs that are combined P-gp and strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole, or ritonavir).
Evaluation of Standard Versus Reduced Dose Apixaban for the …
Criteria for reduced apixaban dosing only exists for the indication of stroke prevention in patients with non-valvular atrial fibrillation (NVAF), with a manufacturer label recommendation to reduce the maintenance dose to 2.5 mg twice daily in patients who meet at least two of the following: age ≥80 years old, actual body weight ≤60 kg, or ...