盘状结构域受体DDR1：一种新型RTKs成员，肿瘤治疗潜力靶标！
Aug 1, 2022 · 在1993年，Johnson等人在研究乳腺癌细胞中的酪氨酸磷酸化时，发现盘状结构域受体（Discoidin domain receptor，DDR），被认为是跨膜受体酪氨酸激酶（RTKs）超家族的成员。 现已鉴定出了2种类型DDR，即DDR1和DDR2 [1]。 DDR由胞内激酶区、跨膜区和胞外区3部分组成。 与RTKs家族的其他成员不同的是，DDR在胞外结构域中存在盘状结构discoidin region（DR），所以被称为盘状结构域受体型蛋白酪氨酸激酶。 DDR作为一种新型的RTKs， …
Discoidin domain receptor 1 (DDR1): an emerged novel …
Feb 24, 2024 · Recently, the discoidin domain receptor tyrosine kinase 1 (DDR1) has emerged as a novel mechanosensor that responds to mechanical cues such as extracellular matrix stiffness, shear stress, and cytoskeletal tension. In this review, we provide updated insights into DDR1 mechanosensing and propose future research directions.
盘状结构域受体DDR1：一种新型RTKs成员，肿瘤治疗潜力靶标！
Aug 9, 2022 · 近年来，越来越多关于盘状结构域受体（DDR）的研究引起关注，尤其是DDR1，大量研究揭示，DDR1在细胞分化、增殖、黏附、迁移中起重要作用，同时也具有促进细胞恶性转化及肿瘤侵袭、转移的作用。 国际顶级期刊Nature早前报道，DDR1的表达，有助于在肿瘤周围建立物理屏障，从而防止T细胞浸润到肿瘤中，阻碍杀伤肿瘤细胞的作用。 那么，抑制DDR1，将可阻断DDR1对免疫细胞的抑制作用。 因此，DDR1作为一种新型RTKs蛋白，成为具有潜力的癌 …
Discoidin domain receptor 1 as a potent therapeutic target in …
Sep 1, 2024 · Discoidin domain receptor 1 (DDR1) has a significant role in crucial cell survival processes. Upon collagen binding, autophosphorylation of its kinase domain leads to downstream signaling pathways. Abnormal expression of DDR1 has been linked with inflammatory diseases, fibrosis, and cancer progression.
Endothelial discoidin domain receptor 1 senses flow to ... - Nature
Oct 13, 2023 · Here, we demonstrate that the discoidin domain receptor 1 (DDR1) tyrosine kinase is a direct mechanosensor and is essential for connecting the force imposed by shear to the endothelial responses....
Discoidin domain receptor 1 as a potent therapeutic target in …
Discoidin domain receptor 1 (DDR1) has a significant role in crucial cell survival processes. Upon collagen binding, autophosphorylation of its kinase domain leads to downstream signaling pathways. Abnormal expression of DDR1 has been linked with inflammatory diseases, fibrosis, and cancer progression.
Inhibition of discoidin domain receptor 1 as a new therapeutic …
Dec 6, 2024 · DDR1 promotes adhesion, proliferation, differentiation, migration, and metastasis of cancer cells. The purpose of this study is to assess the expression, clinical prognostic relationship and functional roles of DDR1 in osteosarcoma.
A network map of discoidin domain receptor 1(DDR1)-mediated …
Dec 1, 2022 · Discoidin domain receptor 1 (DDR1) is one of the receptors that belong to a family of non-integrin collagen receptors. In common, DDR1 is predominantly found in epithelial and smooth muscle cells and its mainly involved in organogenesis during embryonic development.
Signaling by discoidin domain receptor 1 in cancer metastasis
Oct 13, 2018 · Collagen receptor DDR1 is a member of receptor tyrosine kinase (RTK) family with a unique motif in the extracellular domain resembling Dictyostelium discoideum protein discoidin-I. DDR1 displays delayed and sustained activation upon interaction with collagen and recent findings have demonstrated that DDR1-collagen signaling play important role i...
Discoidin Domain Receptor 1 - PMC - National Center for …
Discoidin domain receptor 1 (DDR1) is a receptor tyrosine kinase that binds and is activated by collagens. Transcriptional profiling of cirrhosis in human liver using a DNA array and quantitative PCR detected elevated mRNA expression of DDR1 compared with that in nondiseased liver.