They are distinguished from other endopeptidases by their dependence on metal ions as cofactors, their ability to degrade extracellular matrix, and their specific evolutionary DNA …

Jan 18, 2024 · Summary: We present an overview of the current knowledge regarding matrix metalloproteinases, the regulation of their activity, and their trafficking

Matrix metalloproteinases serve as pivotal regulators of the extracellular matrix (ECM), orchestrating a delicate balance between matrix degradation and synthesis that is essential for …

Jul 22, 2025 · “Matrix” refers to their primary site of action, the extracellular matrix, which provides structural support to cells. “Metallo” signifies that these enzymes require a metal ion, …

Abstract⎯The first matrix metalloproteinase (MMP) was discovered in 1962 from the tail of e suggests, matrix metalloproteinases are proteases capable of remodelling the extracellular …

Apr 17, 2025 · Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases that play a crucial role in extracellular matrix (ECM) remodeling and are implicated in the …

Dec 4, 2020 · Matrix metalloproteinase (MMP) is a class of metalloenzyme that cleaves peptide bonds in extracellular matrices. Their functions are important in both health and disease of …

Matrix Metalloproteinases (MMPs) are elevated in various inflammatory and chronic diseases, including inflammatory bowel disease (IBD), periodontitis, and rheumatoid arthritis, where they …

Feb 4, 2021 · MMPs are a major group of enzymes that regulate cell–matrix composition. They require a zinc ion in their active site for catalytic activity and are critical for maintaining tissue …

Feb 1, 2010 · Matrix metalloproteinases (MMPs) are a family of zinc proteases that degrade most of the components of the extracellular matrix (ECM). MMPs also have a number of non …