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CD4+CD25+ Immunoregulatory T Cells: Immunity - Cell Press
Aug 20, 2001 · CD4 + CD25 + immunoregulatory T cells represent a unique lineage of thymic-derived cells that potently suppress both in vitro and in vivo effector T cell function.
Regulatory T cell - Wikipedia
As defined by CD4 and CD25 expression, regulatory T cells comprise about 5–10% of the mature CD4 + T cell subpopulation in mice and humans, while about 1–2% of T reg can be measured …
CD4+CD25+ suppressor T cells: more questions than answers
Jun 1, 2002 · CD4 + CD25 + T cells are potent suppressors of the activation of both CD4 + and CD8 + T cells in vitro. Suppression is mediated by a cell-contact-dependent, cytokine …
Human CD4+CD25+ cells: a naturally occurring population of …
Nov 1, 2001 · In recent years, a population of CD4 + T cells that constitutively express the interleukin-2 receptor-α chain, CD25, has been shown to play a pivotal role in the …
CD4+CD25+ Immunoregulatory T Cells Suppress Polyclonal T …
In this report, we demonstrate that the population of CD4 + CD25 + T cells present in the peripheral lymphoid system of normal mice is a potent inhibitor of polyclonal T cell activation in …
CD4+CD25+ Immunoregulatory T Cells: New Therapeutics for …
CD4+CD25+ immunoregulatory T cells play a pivotal role in preventing organ-specific autoimmune diseases and in tolerance induction to allogeneic organ transplants. We …
CD4+CD25+ regulatory T cells preserve graft-versus-tumor
Aug 17, 2003 · Here we demonstrate that in host mice with leukemia and lymphoma, CD4 + CD25 + regulatory T cells suppress the early expansion of alloreactive donor T cells, their interleukin …
Human CD4+ CD25+ CD127hi cells and the Th1/Th2 phenotype
CD4+ T cells that co-express CD25 and CD127 (CD25+CD127+) make up around 20% of all circulating CD4+ memory T cells in healthy people. The clinical significance of these cells is …
CD4+ CD25+ T-Cell Production in Healthy Humans and in …
Regulatory T cells are found primarily in the CD4 + CD25 + fraction of T cells and play an important role in the prevention of autoimmunity. We examined CD4 + CD25 + T cells in 33 …
CD4(+)CD25(+) immunoregulatory T cells: gene expression …
CD4(+)CD25(+) immunoregulatory T cells represent a unique lineage of thymic-derived cells that potently suppress both in vitro and in vivo effector T cell function.