CD33 or Siglec-3 (sialic acid binding Ig-like lectin 3, SIGLEC3, SIGLEC-3, gp67, p67) is a transmembrane receptor expressed on cells of myeloid lineage. [5] It is usually considered myeloid-specific, but it can also be found on some lymphoid cells.

Enables protein phosphatase binding activity and sialic acid binding activity. Involved in several processes, including negative regulation of cytokine production; negative regulation of monocyte activation; and positive regulation of protein tyrosine phosphatase activity.

Dec 24, 2024 · CD33 (CD33 Molecule) is a Protein Coding gene. Diseases associated with CD33 include Cardiovascular System Disease and Myeloid Leukemia. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation.

CD33 is a type I transmembrane protein, which belongs to the Siglecs family of sialic acid binding immunoglobulin-like lectins (Siglecs). CD33 is mainly expressed in immune cells, including in microglia within the brain ( Wißfeld et al., 2021 ).

CD33 is a transmembrane protein that is found on cells of myeloid lineage. It is also intensely expressed on acute myeloid leukemia (AML) progenitor cells but not on normal stem cells. It internalizes on binding and dimerization, making it a specific and ideal target for …

The expression of CD33, a restricted leukocyte antigen considered specific for myeloid lineage, has been studied extensively on lymphoid cells. We demonstrated that wide subsets of mitogen- or alloantigen-activated human T and natural killer …

Nov 2, 2024 · Enables protein phosphatase binding activity; protein tyrosine phosphatase activator activity; and sialic acid binding activity. Involved in several processes, including immune response-regulating signaling pathway; negative regulation of cytokine production; and negative regulation of monocyte activation.

CD33 (siglec-3), a well-known target in leukemia therapy, is an inhibitory sialoadhesin expressed in human leukocytes of the myeloid lineage and some lymphoid subsets, including NK cells. It may constitute a control mechanism of the innate immune system; nevertheless, its role as an inhibitory receptor remains elusive.

Dec 24, 2020 · CD33 is a small protein that is often present on tumor cells in acute myeloid leukemia and is therefore the focus of some research to develop targeted treatments for the disease. One such CD33-targeted treatment – gemtuzumab ozogamicin has shown promise in helping acute myeloid leukemia patients.

The CD33 (CD33 molecule) is a protein-coding gene located on chromosome 19. CD33 or Siglec-3 (sialic acid binding Ig-like lectin 3, SIGLEC3, SIGLEC-3, gp67, p67) is a transmembrane receptor expressed on cells of myeloid lineage.

Jan 4, 2025 · Lectin galactoside-binding soluble 3 binding protein (LGALS3BP) is a tumor-associated immunomodulatory ligand for CD33-related Siglecs. Data indicate that glycosylphosphatidylinositol-anchored glycoprotein CD14 controls Toll-like receptor-4 (TLR4)-mediated signaling through the ligation with sialic acid-binding lectin 3 (CD33).

Jan 1, 2006 · In the present work, we have established the expression of CD33 on lymphoid cells by several approaches. We found that activated T and NK cells express the CD33 protein, displaying lower molecular weight than myeloid CD33.

Human CD33 (hCD33) is an immunoglobulin (Ig) superfamily protein expressed on myeloid progenitor cells in the bone marrow and on peripheral blood monocytes. It is known to recognize α2-3- and α2-6-linked sialic acids (7, 18), which are expressed mostly at the nonreducing termini (outermost positions) of glycan chains (5, 38).

Jul 29, 2021 · CD33, located on chromosome 19q13.3, is a sialic acid-binding immunoglobulin-related lectin (siglec) that functions as a transmembrane receptor on hematopoietic cells .

CD33 encodes a member of a superfamily called sialic acid-binding immunoglobulin-like lectins (Siglecs). In microglia, CD33 binds extracellular sialylated glycans on other cells or pathogens.

Jul 15, 2000 · The ability of CD33 to become tyrosine phosphorylated and recruit protein tyrosine phosphatases strongly suggests that it would function as an inhibitory receptor in the myeloid compartment. Many of the cells that express CD33 also …

Mar 5, 2024 · Enables protein phosphatase binding activity and sialic acid binding activity. Involved in several processes, including negative regulation of cytokine production; negative regulation of monocyte activation; and positive regulation of protein tyrosine phosphatase activity.

The myeloid restricted membrane glycoprotein, CD33, is a member of the recently characterized “sialic acid-binding immunoglobulin-related lectin” family. Although CD33 can mediate sialic acid-dependent cell interactions as a recombinant protein, its …

Apr 1, 2023 · CD33 (Siglec-3) is an inhibitory immune receptor and type I transmembrane protein belonging to the family of sialic acid-binding immunoglobulin-like lectins (Siglecs).

Feb 5, 2025 · Of particular interest is CD33, a cell surface receptor protein that is part of the innate immune pathway and plays a critical role in regulating anti-inflammatory signal transduction. Recent evidence has highlighted CD33 ’s significant involvement in AD pathogenesis, suggesting it may be a key molecular link between immune function and ...

Know comprehensive Siglec-3/CD33 protein information including protein sequence, molecular weight, theoretical pI, structure, function and protein interaction.

Feb 4, 2025 · Co-immunoprecipitation and NanoBRET protein–protein interaction assay 30 in HEK293 cells confirmed the direct interaction between 14-3-3ζ and HCAR1 induced by lactate (Fig. 4h,i), while the 14 ...