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Pathology Outlines - CD117
5 days ago · Also known as c-kit, stem cell factor receptor, mast cell growth factor (Appl Immunohistochem Mol Morphol 2005;13:205) Pathophysiology Has activating or gain of function mutations in most GISTs, often at exon 11, less often at exons 9 and 13 ( Hum Pathol 2002;33:484 , Cancer Med 2020;9:6485 , Cureus 2022;14:e20868 )
Pathology Outlines - Stains & CD markers
Small intestine: chromogranin c-kit / CD117 DOG1 Ki67 synaptophysin Stomach: chromogranin c-kit / CD117 claudin 18.2 (pending) DOG1 desmin EBER1 / 2 / LMP gastrin (pending) Helicobacter pylori HER2 stomach GEJ INSM1 Ki67 S100 SMA synaptophysin Warthin-Starry GU / adrenal Adrenal: calretinin chromogranin CK7 GATA3 GD2 (pending) inhibin MelanA ...
Pathology Outlines - Renal cell carcinoma (RCC)
Feb 16, 2022 · However, due to the lack of sensitivity and specificity and emerging utility for PAX8, CAIX, CK7 and CD117 (c-kit), RCC has become less commonly used by pathologists (Histopathology 2020;77:659 Hum Pathol 2021 May 4 [Epub ahead of print])
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12 year old girl with ovarian yolk sac tumor presenting with acute abdominal pain and elevated serum AFP (Acta Biomed 2019;90:599)
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Ultrasound: lack of specific findings (Abdom Radiol (NY) 2018;43:880) Computed tomography (CT) scan Shows irregular mixed density mass shadows (usually > 45 HU) with heterogeneous enhancement, "fast in and fast out" type on contrast enhanced CT scan (Abdom Imaging 2014;39:588, World J Surg Oncol 2015;13:280)
Pathology Outlines - Conferences
Feb 7, 2025 · USCAP Presents: Pancreatobiliary Pathology from A to Z: A Pancreatobiliary Pathology Society Crash Course Embark on an illuminating journey through the intricate world of pancreatobiliary pathology with the comprehensive course – Pancreatobiliary Pathology from A to Z. Developed in collaboration with the esteemed Pancreatobiliary Pathology Society, this …
Pathology Outlines - Case of the Week #421
C. c-kit and Platelet derived growth factor receptor alpha (PDGFRα) D. BRAF and c-kit, but not Platelet derived growth factor receptor alpha (PDGFRα) Discussion: The images show a polypoid mass expanding the submucosa.
Pathology Outlines - Solid pseudopapillary tumor
Jul 7, 2023 · c-kit- Consistent keratin expression Consistent positive expression of both chromogranin and synaptophysin ...
Pathology Outlines - Papillary
Nov 1, 2023 · Predominantly papillary or tubulopapillary architecture (Mod Pathol 2021;34:1392) Lined by cells with variation of morphologies, ranging from small, basophilic cuboidal cells with inconspicuous nucleoli to large, eosinophilic cells with prominent nucleoli; may have clear cytoplasm, known pitfall to have clearing in PRCC
Pathology Outlines - Case of the Week #448
c-Kit may be expressed in up to 40% of spermatocytic tumors. The lack of a lymphoid component, as demonstrated by the absence of staining with CD45, further underscores the diagnosis in the case presented here. Gain in chromosome 9 is the most consistent cytogenetic abnormality, in addition to gain of the X chromosome.