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KIT (gene) - Wikipedia
c-KIT plays an important role in regulating many mechanisms leading to tumor formation and progression of carcinomas. c-KIT has been proposed as a regulator of stemness in several cancers.
Role and significance of c-KIT receptor tyrosine kinase in cancer: A ...
c-kit is a classical proto-oncogene that encodes a receptor tyrosine kinase (RTK) that responds to stem cell factor (SCF). C-KIT signaling is a critical regulator of cell proliferation, survival, and migration and is implicated in several ...
KIT Gene - GeneCards | KIT Protein | KIT Antibody
Dec 25, 2024 · This gene was initially identified as a homolog of the feline sarcoma viral oncogene v-kit and is often referred to as proto-oncogene c-Kit. The canonical form of this glycosylated transmembrane protein has an N-terminal extracellular region with five immunoglobulin-like domains, a transmembrane region, and an intracellular tyrosine...
c-Kit Receptors as a Therapeutic Target in Cancer: Current Insights
c-Kit is a type III receptor tyrosine kinase (RTK) that has an essential role in various biological functions including gametogenesis, melanogenesis, hematopoiesis, cell survival, and apoptosis. c-KIT aberrations, either overexpression or ...
Receptor tyrosine kinase (c-Kit) inhibitors: a potential …
c-Kit, a receptor tyrosine kinase, is involved in intracellular signaling, and the mutated form of c-Kit plays a crucial role in occurrence of some cancers. The function of c-Kit has led to the concept that inhibiting c-Kit kinase activity can be a ...
A holistic view on c-Kit in cancer: Structure, signaling ...
Dec 1, 2021 · The c-Kit receptor is encoded by a proto-oncogene present in the long-arm region of chromosome 4 (4q11–4q13) [30], spanning more than 34 kb of DNA. It maps to chromosome 12 in humans and chromosome 10 in the mouse and is …
KIT KIT proto-oncogene, receptor tyrosine kinase [ (human)]
This gene encodes a receptor tyrosine kinase. This gene was initially identified as a homolog of the feline sarcoma viral oncogene v-kit and is often referred to as proto-oncogene c-Kit.
Regulation of the hematopoietic stem cell pool by C-Kit ... - Science
Aug 9, 2024 · Our data suggest that constitutive trogocytic activity of HSCs is a common and regulated event. Moreover, our data suggest that c-Kit is a critical pathway regulating HSC trogocytosis. High c-Kit expression and signaling is linked to …
Stem cell factor receptor/c-Kit: from basic science to clinical ...
Stem cell factor (SCF) is a dimeric molecule that exerts its biological functions by binding to and activating the receptor tyrosine kinase c-Kit. Activation of c-Kit leads to its autophosphorylation and initiation of signal transduction.
c-Kit Receptors as a Therapeutic Target in Cancer: Current
Sep 27, 2023 · c-Kit is a type III receptor tyrosine kinase (RTK) that has an essential role in various biological functions including gametogenesis, melanogenesis, hematopoiesis, cell survival, and apoptosis. c-KIT aberrations, either overexpression or loss-of-function mutations, have been implicated in the pathogenesis and development of many cancers ...
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