Section 2, Definition, Pathophysiology and Pathogenesis of Asthma…
Asthma is a common chronic disorder of the airways that involves a complex interaction of airflow obstruction, bronchial hyperresponsiveness and an underlying inflammation. This interaction can be highly variable among patients and within patients over time.
Pathophysiology Of Asthma - StatPearls - NCBI Bookshelf
Jun 24, 2023 · Asthma is most likely transmitted by multiple genes, with some variation of locus heterogeneity and polygenic inheritance leading to asthma expression being multifaceted. Atopy or IgE antibodies attack specific antigens or pollutants, which can contribute to the disease.
Pathogenesis of asthma - UpToDate
Nov 14, 2024 · The inflammatory, physiologic, and structural factors that contribute to the pathogenesis of asthma will be reviewed here, focusing on aspects that aid in understanding the clinical presentation of asthma and its treatment.
Asthma - StatPearls - NCBI Bookshelf
May 3, 2024 · Asthma is characterized by complex pathophysiology involving airway inflammation, intermittent airflow obstruction, and bronchial hyperresponsiveness. The condition presents various signs and symptoms, such as wheezing, coughing, shortness of breath, and chest tightness.
Current Understanding of Asthma Pathogenesis and Biomarkers
Asthma is a heterogeneous lung disease with variable phenotypes (clinical presentations) and distinctive endotypes (mechanisms). Over the last decade, considerable efforts have been made to dissect the cellular and molecular mechanisms of asthma.
Pathophysiological Mechanisms of Asthma - PMC
Asthma Pathophysiology: Hypothesis Generating Studies. Gene expression is regulated in part by non-coding RNA, and this has been a subject of asthma research. In adults with severe asthma, activation status of CD4 and CD8 lymphocytes was related to non-coding RNA expression.
Asthma: Pathophysiology and Diagnosis - PMC - PubMed …
In this chapter, we will briefly explore some major theories of asthma pathogenesis, both new and old. We will also explore how understanding the pathophysiology of asthma can help us to understand the symptoms and presentation of asthma, as well as the best strategies for diagnosing this disease.
Pathophysiology of asthma - Wikipedia
The fundamental problem in asthma appears to be immunological: young children in the early stages of asthma show signs of excessive inflammation in their airways. Epidemiological findings give clues as to the pathogenesis: the incidence of asthma seems to be increasing worldwide, and asthma is now very much more common in affluent countries.
Pathophysiology of Asthma - an overview | ScienceDirect Topics
Asthma is characterized by inflammation of the airways, with an abnormal accumulation of inflammatory cells in the bronchioles. Asthma is associated with increased responsiveness of the tracheobronchial tree from many different stimuli, either singly or in combination with each other.
Pathogenesis of asthma - Medical Clinics
The pathogenesis of asthma clearly involves many cells and mediators, although the contribution of each individual factor is probably different from patient to patient depending on the setting and stimulus.