PFKFB3 is a gene that encodes the 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 enzyme in humans. [5][6][7] It is one of 4 tissue-specific PFKFB isoenzymes identified …

Dec 25, 2024 · PFKFB3 (6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 3) is a Protein Coding gene. Diseases associated with PFKFB3 include Colon Adenocarcinoma and …

Nov 24, 2017 · In this review, we summarize current knowledge of PFKFB3 regulation by several signal pathways and its function in cancer development in different cell types in cancer tissues.

PFKFB3 levels affect angiogenesis through mediating VEGF activity, where PFKFB3 upregulation results in enhanced VEGF activity. Moreover, silencing of PFKFB3 impairs angiogenesis, …

PFKFB3 is an essential target of EGFR signaling and that PFKFB3 activation is required for glycolysis stimulation upon EGFR activation. PFKFB3 has a key role in mediating glucose …

In this review, we summarize current knowledge of PFKFB3 regulation by several signal pathways and its function in cancer development in different cell types in cancer tissues. Ubiquitous …

5 days ago · Results: Our findings show a neuroprotective effect of PFKFB3 inhibition after stroke in both female and male aged mice. Mice receiving the PFKFB3 inhibitor showed significantly …

Mar 1, 2013 · PFKFB3 has the highest Kinase/Bisphosphatase activity ratio (K/B=700) which promotes high concentrations of Fru-2,6-P2. PFKFB3 protein consists of two homodimeric …

Phosphofructokinase-2/fructose 2,6-biophosphatase 3 (PFKFB3), a key rate-limiting enzyme in glycolysis, exhibits strong kinase activity. Inhibition of PFKFB3 can reduce the rate of …

a Kaplan–Meier analysis for overall survival (OS) of patients based on the data of TCGA. The OS of the PFKFB3 high expression group was worse than that of the PFKFB3 low expression …