Dr. Tycel Phillips discusses the implications of the FDA approval of Calquence plus bendamustine and Rituxan in untreated MCL ...

Activation of p53 also promotes an anti-tumour immune ... ‘Brightline-1’, comparing BI 907828 with doxorubicin in first-line treatment of patients with advanced dedifferentiated liposarcoma ...

Doxorubicin and sorafenib have been commonly used in ongoing ... proposed to regulate CYP3A4 in response to hypoxia through the expression of HIF1-α and p53 expression (57). Alternation of molecular ...

During the past 20 years, the advent of neoadjuvant, primary, and adjuvant concurrent chemoradiotherapy has improved cancer care dramatically. Significant contributions have been made by ...

George Coukos, MD, PhD, Department of Oncology, University Hospital of Lausanne, Rue du Bugnon 46, Lausanne 1011, Switzerland; e-mail: [email protected]. If you have the appropriate software installed ...

The key tumor suppressor protein p53, additionally known as p53, represents an attractive target for the development and management of anti-cancer therapies. p53 has been implicated as a tumor ...

Estrogens have been reported to cause dysfunction in biliary transport systems, thereby inducing cholestasis. Multidrug resistance-associated protein 2 (MRP2) is a transporter responsible for ...

Background While p53 mutations occur early in Barrett’s oesophagus (BE) progression to oesophageal adenocarcinoma (EAC), their role in gastric cardia stem cells remains unclear. Objective This study ...

In an attempt to minimize the risk of publication bias, conference abstracts and proceedings were searched through Web of Science, Embase and Scopus using the terms o/esophagus* and p53*. Further, the ...

The inactivation of programmed cell death has profound effects not only on the development but also on the overall integrity of multicellular organisms. Beside developmental abnormalities, it may lead ...

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