CYP2D6 Copy Number Determination using Digital PCR. Presented at: For the Love of Digital PCR 2024 ... This method integrates “one-pot” enzymatic restriction digestion with a custom triplex TaqMan™ ...

Copy number variation (CNV) of the cytochrome P450 2D6 (CYP2D6) gene, including deletions and gene multiplications, can result in reduced or increased metabolism of many clinically relevant drugs.

Second, CYP2D6 copy number variations (CNVs) have not been fully considered. In this correspondence, we wish to draw attention to this important area of research on CYP2D6.

DNA from 206 patients receiving adjuvant tamoxifen monotherapy and from 280 patients not receiving tamoxifen therapy (71 months median follow-up) was isolated from archival material and was genotyped ...