The researchers found that ICA plays a crucial role in limiting inflammation by disrupting NLRP3 inflammasome activation in ...

More information: James R. O'Siorain et al, Time‐of‐day control of mitochondria regulates NLRP3 inflammasome activation in ...

Macrophages release interleukin-1 (IL-1) cytokines in response to inflammatory stimuli, and the NLRP3 inflammasome mediates IL-1-family cytokine release via pyroptosis.

Exposure to particulate crystals can induce oxidative stress in phagocytes, which triggers NLRP3 inflammasome-mediated interleukin-1β secretion to initiate undesirable inflammatory responses that ...

Inflammasomes are more active in the morning than the rest of the day. Macrophage activity, which regulates inflammation, is influenced by the biologic clock in the body. A team led by Annie ...

ZyVersa Therapeutics Highlights Data Demonstrating NLRP3 Inflammasome Inhibition Reduces Inflammation, Improves Heart Function, and Restores Glucose Homeostasis and Insulin Sensitivity in Obese ...

Mechanisms of macrophage regulation mediated by iron-based mag netic nanomaterials. SOD, superoxide dismutase; POD, peroxidase; CAT, cata lase; NF-κB, nuclear factor-kappa B; MAPK, mitogen ...

Mononuclear macrophages serve as the primary target cells for the in vivo metabolism of iron ... STAT, and NLRP3 pathways, thus promoting macrophage inflammatory or anti-inflammatory immune ...

New research from RCSI University of Medicine and Health Sciences has explained how the body’s internal clock influences the inflammatory process of the immune system.