and kinetic data suggest a sequential mechanism that is initiated by binding to cyclin A. p27 regulates CDK–cyclin complexes involved directly in cell cycle control and does not interact with ...

Finally, cyclin B binds to CDK-1 to drive the cycle forward into M phase, stimulating mitosis. Upon external signals, CDK inhibitors can be used to block the CDK kinase activity, thereby ...

The function of cyclins in the cell cycle Cyclins have no enzymatic function of their own, and instead bind to CDKs to activate ... Phosphorylation by CDK-2-cyclin E complex prevents this ...

The researchers also discovered how proteins like p27 can identify and bind to complexes with different types of Cdk and cyclin, such as Cdk4-cyclin D--an ability that is critical for them to ...

Because cyclin D1 binds to the same estrogen receptor as does BRCA1, when the cell is flooded with cyclin D1, BRCA1 is unable to activate a pathway that stops cancer development. Study results ...

Cyclin-dependent kinases (cdks ... However, built-in redundancy may limit the effects of highly selective cdk inhibition. Cdk4/6 inhibition has been shown to induce potent G 1 arrest in vitro and ...

To the Editor: Keyomarsi et al. (Nov. 14 issue) 1 present the exciting and powerful finding that the levels of cyclin E in breast-cancer cells, as measured with the Western blot assay, correlate ...