Desire to identify antigen-specific T cells through the MHC/peptide complex was always there ... Viruses (Human Immunodeficiency Virus-Acquired Immunodeficiency Syndrome, Epstein Barr ...

This finding supports the idea that antigenic peptides are derived from ‘freshly made’ proteins. TAP–GFP motility was also correlated with the transport of MHC class I molecules from the ER ...

While it's known that major histocompatibility complex class I (MHC-I) plays a central role in orchestrating immune responses to cancer, less is known about the reactivity of peptides displayed by ...

DNA vaccines contain the nucleotides encoding an antigenic portion of the virus such as the ... into intracellular peptides (4). The vaccine derived-peptide binds MHC class I molecules (5).

The influenza virus kills hundreds of thousands of people ... which could limit CD4 + T cell responses owing to a bias in MHC-II peptide presentation,” they wrote. They reasoned that ...

Our core provides customized MHC/peptide tetramers for identification of antigen-specific T lymphocytes by flow cytometry. Tetramers and/or their derivatives are provided for research purposes only.

For an epitope to be recognized by T cells, foreign antigens need to be cut into short peptides with proper sizes in order to form physical complexes with MHC molecules. A few aminopeptidases have ...