Major histocompatibility complex (MHC) class I presentation of peptides to T cell receptors (TCR) on T lymphocytes is the key in the immune response. Because of their unique specificity, MHC-peptide ...

T cells use the T cell antigen-receptor (TCR) to recognize their antigens, which are often in the form of peptides bound to major histocompatibility complex molecules (MHC), also called HLA (human ...

Performing experiments in T cells expressing a TCR transgene enables the engagement of the TCR by its natural ligand peptide-MHC complex, whereas the use of professional APCs provides ligands to as ...

And what peptide-MHC complexes are ideal targets for immunotherapies, especially for TCR-mimic antibodies. When I am not in the lab I love to cook, sing and explore the playgrounds of NYC with my ...

TCRs are protein complexes located on the surface of T cells that recognize and bind to antigen peptides presented by major histocompatibility complex ... seq improves TCR screening to more ...

D.H. Fremont, M. Matsumura, E.A. Stura, P.A. Peterson, I.A. Wilson, "Crystal structures of two viral peptides in complex with murine MHC class I H-2Kb," Science, 257: ...

(2018) Stress-testing the relationship between T cell receptor/peptide-MHC affinity and cross-reactivity using peptide velcro. Proc. Natl. Acad. Sci USA. 115, E7369-7378. PMID: 30021852 Sibener LV, ...