As seen in Figure 2, the tomography revealed that around 98% of tagged T cell receptors budded outward from the killer T cell’s edges via right-side out microvesicles called ectosomes.

During early drug development and preclinical development, researchers use in vitro cultured lymphocytes to induce cytokine ...

According to new research in the journal Immunity, T cells have a nuclear receptor doing something very odd ... Myers hopes to figure out exactly what RARα does in the TCR/ZAP70 signaling complex.

According to new research, T cells have a nuclear receptor doing something very odd—but very important—to help them fight pathogens and destroy cancer cells. This receptor, called retinoic ...

U.S. and Chinese researchers appear to have unlocked a novel way to stop T cells from attacking the body in MS and other ...

CAR-T cells are engineered to carry synthetic membrane-spanning receptor molecules that use their outside-facing portion to bind to antigens on cancer cells, which their inside-facing portion ...

T cells are a critical part of the adaptive immune system that respond to pathogens, tumors, or play a key role in autoimmune diseases. A T cell recognizes potential targets through its T cell ...

In a paper published Jan. 2 in Nature Biotechnology, they described the addition of “decoy” receptors on CAR-T cells, which the antibodies preferentially bound to over other receptors on the cell.

The added receptor on the T cell’s surface helps your immune system “see” specific proteins on the surface of cancer cells. In multiple myeloma cells, this is a protein called BCMA.

It is the first T-cell receptor gene therapy to gain FDA approval. The approval was based on results from a multicenter, single-arm, open-label, clinical trial (SPEARHEAD-1, Cohort 1).

Chimeric antigen receptor (CAR) T-cell therapy has been an exciting area of development for autoimmune disease treatment. Previous reports had not mentioned any particular constellation of adverse ...