STAT (moderator) 7:25-7:35 p.m. CT – How Advancements in Biomarker Testing Pave the Way for Better Lung Cancer Treatment Sponsor Session For decades, lung cancer seemed unbeatable. But the ...

Panelists discuss how riociguat targets the nitric oxide pathway and is approved for both Group 1 PAH and Group 4 chronic ...

A major effort of my research lab is to identify novel therapeutics for small cell lung cancer (SCLC ... role in thoracic cancer and leads to downstream activation of the JAK-STAT pathway, ...

This is in part because lung cells can be driven to a profibrotic phenotype by multiple pathways that reinforce each other, so that targeting one pathway alone may not be effective to slow or stop ...

Moreover, the investigators used post-acute sequelae of SARS-CoV-2 pulmonary fibrosis patient cohorts to validate the abnormal immunologic pathways, corroborating the animal model work. “Although we ...

The emergence of drugs inhibiting the JAK-STAT pathway has culminated in tyrosine kinase 2 inhibitors targeting psoriatic arthritis, lupus and other indications, noted a presenter at the 2022 ...

There is also evidence to suggest that in adults, the pathway becomes reactivated after tissue injury, which can occur in lung epithelia, Maher explained. Although as the word idiopathic in IPF ...

Using innovative spatial proteomics – one of the most advanced molecular biology tools – the team identified the inflammatory JAK/STAT pathway as the main driver of disease. After validating their ...

BMPER attenuated PI3K/AKT signaling and suppressed BMP4-driven smooth muscle activation in models of PAH. BMPER overexpression mitigated the vascular remodeling that characterizes pulmonary arterial ...