Stay up to date on the latest science with Brush Up Summaries. Despite its significance, alternative splicing’s global impact on cellular homeostasis and intricate molecular mechanisms remains ...

What are the mechanisms of alternative splicing? Prior to RNA splicing, RNA polymerase II produces pre-mRNA transcripts by transcribing gene sequences into a collection of non-coding introns and ...

Biologists have discovered a new type of RNA-splicing regulation that helps to determine which protein-coding exons will be included in messenger RNA transcripts. RNA splicing is a cellular ...

A wide spectrum of cancer-associated genetic alterations, including those that result in changes to the splicing of pre–messenger RNA (mRNA), can lead to the presentation of aberrant peptides as ...

A study published Wednesday (March 1) in Science Advances suggests that cohesin regulates alternative splicing—the phenomenon when coding regions of a gene are combined in different ways during ...