The researchers found that ICA plays a crucial role in limiting inflammation by disrupting NLRP3 inflammasome activation in ...

Mechanisms of macrophage regulation mediated by iron-based ... signal transducer and activator of transcription; NLRP3, nucleotide- binding oligomerization domain-like receptor family pyrin ...

More information: James R. O'Siorain et al, Time‐of‐day control of mitochondria regulates NLRP3 inflammasome activation in ...

whereas an NLRP3 inflammasome is found mostly within immune cells such as macrophages and neutrophils, hence the wide applicability of this inhibitor Adiso Therapeutics is currently running pre ...

The authors reported that NOD-like receptor protein 3 (NLRP3) inflammasomes are particularly active in the early morning when macrophages are the most efficient. NLRP3 inflammasomes mediate the ...

and NLRP3 pathways, thus promoting macrophage inflammatory or anti-inflammatory immune responses “Additionally, iron-based magnetic nanomaterials are involved in cellular iron cycling and iron ...

By targeting ASC, IC 100 inhibits activation of multiple inflammasome pathways activated in obesity (NLRP3, AIM2), heart failure (AIM2, NLRP3, NLRC4), and insulin resistance (AIM2, NLRP1 ...