To examine this interferon-neuron pathway — known as an interferon-induced STAT1 signaling pathway — further and ... immune ...

The STAT family has six members (STAT1–6), each of which transduces the signal of particular cytokines. For instance, signaling from the interferon (IFN) receptors, interleukin-4 (IL-4 ...

Single-cell RNA sequencing (scRNA-seq) of tumor infiltrating CD8 + T cells showed ... thereby limiting downstream STAT1-mediated TRM reprogramming. Based on the role of the key E3 ligase BFAR ...

Filiano and colleagues at Duke worked with a team at Columbia University that bred mice with a STAT1 mutation. Using these mice, they were able to over-activate the immune pathway in different ...

With the aging process, the risk of developing cancer significantly increases ... thereby limiting downstream STAT1-mediated TRM reprogramming. Based on the role of the key E3 ligase BFAR in ...