Researchers have found that, in cells grown in the lab, repeat-containing RNAs and their proteins combine to form solid, gel-like clumps in the cytoplasm that ultimately kill the cell. ... Expanded ...

"We also examined the molecular mechanism of m 6 A regulation on C9 repeat RNA," Sun said. "Finally, we measured neuron survival to examine the rescue efficacy by modulating the m 6 A pathway.

Biochemically, too, the two diseases present different mechanisms of RNA toxicity. In muscular dystrophy, the CUG repeat is in a mature mRNA and the compound does not affect the mRNA levels. Instead, ...

Scientists have found a novel way to block the transportation of mutant RNA and subsequent production of toxic repeat proteins which lead to the death of nerve cells in the most common subtypes of ...

Intracerebral CWG-cPIP inhibited polyQ accumulation and nuclear CUG RNA foci in AAV-mediated CWG repeat-expressing mice, ameliorating cognitive deficits and neuronal dysfunction, without any off ...

Repeat untranscribed DNA sequences are generally thought to be genetic junk at best, harmful at worst, but in ribosomes they are essential to repairing DNA damage, according to a study published this ...