The authors have obtained evidence that destruction of the retinal pigment epithelium (RPE) causes choriocapillaris (CC) atrophy. The observations led us to hypothesize that the RPE modulates CC ...

Apellis Pharma has become the first company to claim FDA approval for a drug to treat geographic atrophy (GA), a ... loss of photoreceptors and retinal pigment epithelial (RPE) cells, the central ...

Newcells' retinal ... of retinal pigment epithelial cells derived from human induced pluripotent stem cells that replicate the phagocytosis of outer segments of photoreceptors. The RPE cells ...

New disks are generated at the nuclear end of the stack and old disks are shed at the tip of the rod outer segment (ROS) where they are digested by phagocytic cells of the retinyl pigmented epithelium ...

Pigment changes—also called retinal pigment epithelium (RPE) disturbances—can lead to vision loss. The RPE is the pigmented ...

We used patient iPSC-derived retinal pigment epithelium (RPE) and retinal organoids for a common RP2 nonsense mutation that causes X-linked retinitis pigmentosa, to test if translational read ...

—The location of vision loss within the central retina has a significant impact on daily life in patients with geographic atrophy. With this in mind, a new study examined structural and ...

The phase 1b trial will enrol patients with geographic atrophy secondary to age ... by the loss of photoreceptors and retinal pigment epithelial (RPE) cells in the central portion of the retina ...

(B) In control mice with AMD, black drusen accumulation and atrophy and deformation of the retinal pigment epithelium were observed. In contrast, peptide-treated mice showed retinal protection ...