Wilms tumor is a type of kidney cancer that largely ... in the accumulation of additional driver mutations in specific pathways, which could be targeted in future drug development.

Given the striking link between β-catenin signalling and the development of Wilms tumour, it is tempting to speculate that mutations in other members of the β-catenin pathway, which could affect ...

“The fact that loss of the salvage pathway in tumors seems to restrict tumor growth…is quite surprising,” said Kasper Fugger, a cancer cell biologist at University College London who did not ...

Thus, loss of function of the p53 tumor suppressor can facilitate both angiogenesis and resistance to apoptosis (e.g., in the five-step pathway shown), as well as enabling the characteristic of ...

According to her mom, Penny was diagnosed with Wilms tumor, which is cancer in the kidneys, last April. The Children's Hospital says 75% of cases occur in kids below the age of 5. Penny's mom says ...