A complete hydatidiform mole (CHM) is a conceptus with only sperm-derived chromosomes. Here, we report on a CHM with genomic DNA identical to that of the paternal somatic cells. The CHM developed i ...

Hydatidiform moles are pregnancies characterized by abnormal development of both embryonic and extraembryonic tissues and are associated with the misexpression of imprinted genes. The vast ...

A: Further investigations, e.g., ultrasound, X-ray, CT or MRI scans, will be needed to confirm the diagnosis of cancer and see the extent of disease. If present chemotherapy is given and in almost ...

Hydatidiform moles, which occur in one in every 1000 pregnancies in the United States, increase the risk of persistent gestational trophoblastic disease (GTD) and choriocarcinoma, a malignant ...

Our laboratory is most interested in the study of a rare class of highly recurrent hydatidiform moles. These are usually CHM, although possibly sometimes PHM, that are indistinguishable from ...

Hayashi, K, Bracken, MB, Freeman, DH Jr, Hellenbrand, K. Hydatidiform mole in the United States (1970-1977): a statistical and theoretical analysis. Am J Epidemiol 1982;115:67-77 Crossref ...

A hydatidiform mole, or molar pregnancy, is an abnormal form of pregnancy in which a nonviable fertilized egg implants in the uterus. Partial and complete hydatidiform moles overexpress paternal ...

More information: Maryam Rezaei et al, Defects in meiosis I contribute to the genesis of androgenetic hydatidiform moles, Journal of Clinical Investigation (2024). DOI: 10.1172/JCI170669.

Researchers from the Johns Hopkins Medical Institutions have used short tandem repeat (STR) genotyping and p57 immunohistochemistry to distinguish hydatidiform moles. The related report by Murphy ...

Patients with a high hCG level 6 months post-hydatidiform mole evacuation are advised chemotherapy. However, close surveillance may be more than sufficient in a number of these patients.