Here, we discuss the latest discovery of histone-modification readers and how the modification language is interpreted. Cell Research - Readers of histone modifications. Skip to main content.

Histone post-translational modifications (PTMs) can directly influence histone-DNA and histone-histone interactions, or they can be targeted by protein effectors, or histone readers. This Review ...

However, readers of many histone marks are still unknown, which limits our ability to understand their roles in gene regulation. A long-standing interest of Professor Li's lab is the development ...

Histone modification is an epigenetic mechanism that regulates gene expression by altering chromatin structure and DNA accessibility for transcription. Histone modification is regulated by various ...

Musselman et al (2012) Perceiving the epigenetic landscape through histone readers. Nat.Struct.Mol.Biol. 19 1218. Featured Products for Epigenetic Readers. BET Bromodomain Inhibitor .

One such method uses a peptide containing a histone mark (i.e., a small fragment of histone protein) that acts as the 'bait' to 'fish' for 'readers' that recognise the mark.

The researchers examined the protein ZMYND8, which, as a histone “reader,” can recognize these histone changes, potentially influence gene expression and head off metastasis.

Reading histone modifications, ... The light bulb symbolizes TRIM24, a 'histone reader"'protein, which binds chromatin. Chromatin association triggers signaling to TRIM24, ...

As researchers have delved into how histone proteins’ tails are modified, they have discovered specialized proteins that serve as writers, erasers, and readers that add, remove, and bind to ...

Despite its biological significance in gene regulation, the mechanism of how this mark is 'translated' is unclear, as the 'readers' of H3K79me2 have not been found since its discovery 20 years ago.

Na Li et al. ZMYND8 Reads the Dual Histone Mark H3K4me1-H3K14ac to Antagonize the Expression of Metastasis-Linked Genes. Molecular Cell , July 2016 DOI: 10.1016/j.molcel.2016.06.035 Cite This Page : ...

Histone modification important for correct blood cell formation. ScienceDaily . Retrieved June 11, 2025 from www.sciencedaily.com / releases / 2024 / 12 / 241218132142.htm ...