Ferroptosis can also be induced by p53 by the repression of SLC7A11. Moreover, the acetylation -defective mutant, p533KR, retains the ability to induce ferroptosis when normal p53 functions fail ...

Ferroptosis contributes to immunosuppression. Higher Education Press . Journal Frontiers of Medicine DOI 10.1007/s11684-024-1080-8 ...

Iron-dependent ferroptosis, a non-apoptotic cell death mechanism, is gaining attention for its role in immune suppression. Ferroptosis, driven by excessive lipid peroxides and iron-dependent ...

“It is unclear whether, and how, ferroptosis is involved in T-cell immunity and cancer immunotherapy. Here we show that immunotherapy-activated CD8 + T cells enhance ferroptosis-specific lipid ...

The development of ferroptosis-based nanotherapeutics is generally limited by poor penetration depth into tumors and potential systemic toxicity. In a recent issue of International Journal of ...

In the case of spinal injury, acrolein's hazard may be the key in causing debilitating paralysis that sets in after the initial trauma. "When a spinal cord ruptures, ...

A mobile lab monitoring for air pollution at the site of the Norfolk Southern train derailment in East Palestine, Ohio, found one potential chemical of concern at higher levels than normal, a team ...

According to the study, levels of a chemical irritant called acrolein detected near the derailment site on Feb. 20 and 21 were up to six times higher than normal levels recorded before the disaster.