The blood–brain barrier is the biggest challenge to the development of drugs that target the CNS. Most capillary beds leak plasma contents between and across endothelial cells by way of window-like ...
Key Laboratory of Analytical Chemistry for Life Science of Shaanxi Province, School of Chemistry and Chemical Engineering, Key Laboratory of Applied Surface and Colloid Chemistry, Ministry of ...
Understanding how bacteria control the entry and efflux of chemicals helps us to explain and possibly reverse antimicrobial drug resistance. Even when antimicrobials gain access via porins, they are ...
1). Indole carboxamide efflux pump inhibitors (EPIs) represent a new drug class designed to restore the efficacy of existing antibiotics against MDR Gram-negative bacteria. TAXIS’ EPIs have been ...
Background: Earlier publications have suggested a possible role for the efflux transporter breast cancer resistance protein (BCRP) in acquired resistance to disease-modifying antirheumatic drugs ...
To reduce side effects and overcome known drug resistance mechanisms, the optimized camptothecin is designed to have high permeability and a low efflux ratio 1. VIP236 shows elastase-dependent ...
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