Accordingly, the PI3K pathway was the primary effector of ... albeit ancillary proliferative and survival signal in c-Kit mutant melanoma cells. As a result, these melanoma cells did not require ...

Accumulating evidence suggests that c-kit-positive cells are present in the remodeled pulmonary vasculature bed of patients with pulmonary hypertension (PH). Whether stem cell factor (SCF)/c-kit ...

In gastrointestinal stromal tumors (GIST), small cell lung cancer (SCLC), leukemia, mastocytosis, and glioblastoma, abnormal signaling of SCF/c-Kit is a crucial promoter of cancer stemness.

In understanding the role of the c-kit signaling pathway, investigators are optimistic they might be able to strengthen the heart-repair process, a prospect particularly important in stem-cell ...

The study being presented evaluated the molecular basis of inhibition of the stem cell factor (SCF)/c-Kit signaling pathway via briquilimab and its functional impact on healthy human HSC survival ...

In this case, it is a “gain of function” mutation that causes the c-kit signaling pathway to be constantly in the “on” state. The critical protein in this pathway is the receptor tyrosine kinase KIT, ...

c-Kit (CD117), a type III receptor tyrosine kinase (RTK), is involved in intracellular signaling. c-Kit and its ligand stem cell factor (SCF) are essential for embryonic development and the ...