Oncogene - Dab2 stabilizes Axin and attenuates Wnt/β-catenin signaling by preventing protein phosphatase 1 (PP1)–Axin interactions Skip to main content Thank you for visiting nature.com.

A small-molecule activator of Wnt/β-catenin signaling acts by binding a negative regulator of β-catenin, Axin, leading to a conformational change that promotes association of Axin with LRP6. The ...

Clearly, altering the gene somehow changes the dynamics and structure of the Wnt blob. And while both Axin and APC comprise the droplet, the pathway appears much more sensitive to issues with the ...

Additionally, mutations in AXIN and APC, which regulate β-catenin degradation, further enhance Wnt/β-catenin signaling. Research also reveals that EVs play a significant role in modulating this ...

PP2A can also enhance Wnt signaling by dephosphorylating β-catenin, APC, and Axin. The result is the preservation of β-catenin by preventing ubiquitination and proteasomal breakdown.

Additionally, mutations in AXIN and APC, which regulate β-catenin degradation, further enhance Wnt/β-catenin signaling. Research also reveals that EVs play a significant role in modulating this ...

Among the key communication systems within a cell is the Wnt signaling pathway, which regulates embryonic development and whose deregulation can also contribute to cancer development. Scientists ...

Researchers from the University of Maryland presented preclinical data for YA-6060, a novel small molecule showing dual activities of Wnt inhibition and AMPK activation via the mechanism of AXIN ...

Aberrant Wnt signaling has also been identified as a key mechanism in cancer biology. This article summarizes both the canonical (β-catenin dependent) and non-canonical (β-catenin independent) ...

In the absence of Wnt, β-catenin is phosphorylated by GSK-3β in a complex containing axin and APC, thus targeting its ubiquitination and degradation by the proteasome.

“Having first confirmed that Axin 2 expression and hence Wnt/β-cat signaling is upregulated following tooth damage, we reasoned that addition of Wnt signaling agonists may provide an effective ...